Clinical trials: Neurobehavioral Manifestations
Mental Retardation
Effect of Valproate on Propofol
The aim of this study is to evaluate the effect of valproate on the required dose of propofol for sedation in patients with mental retardation.
- Trial name
- NCT01170377
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Okayama University
Anesthesia, Hip Osteoarthritis
The Assessments of the Postoperative Recovery on Elderly Patients Received General Anesthesia or Peripheral Nerve Blocks
Postoperative recovery is always worrisome to the elder patients undergoing Total Hip Replacement (THR). Peripheral Nerve Blocks (PNBs), lumbar plexus block combined with sciatic nerve blocks, may be alterative anaesthesia style…
- Trial name
- NCT01782612
- Testing
- Multimodal analgesic techniques, Total uni-Hip Replacement
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Junle Liu
Pain Management, Fear
Effects of Virtual Reality and Helfer Skin Tap During Vaccination
The aim of this study was to detect and compare the effects of Virtual Reality and Helfer Skin Tap methods on pain, fear, anxiety, and satisfaction during the administration of Tetanus-Diphtheria vaccine to school-aged children.
- Conditions
- Pain Management, Fear, Anxiety, Satisfaction
- Trial name
- NCT06895330
- Testing
- Virtual Reality Group, Helfer Skin Tap Group
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Ersoy University
Closed Reduction Surgery for Nasal Bone Fracture
The Relationship Between the Surgery-related Anxiety and HRV: Prediction for Aggressive Emergence Behavior
Heart rate variability (HRV) is known to reflect the balance of autonomic nervous system. Anxiousness, which tend to result from the deficient action of parasympathetic nervous system, likely to show low HRV.
- Trial name
- NCT02282865
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Minimally Conscious State
Neurological and Physiological Effects of Animal-assisted Therapy for Patients in a Minimally Conscious State
This study aims to explore the impact of Animal Assisted Therapy (AAT) on brain signal complexity in patients with minimally conscious state (MCS) by analyzing electroencephalogram (EEG) entropy.
- Trial name
- EMCS (NCT06931665)
- Testing
- Animal Assisted Occupational Therapy
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people
- Sponsor
- University of Basel
Single Sided Deafness, Unilateral Deafness
Cochlear Implants in Young Children With SSD
The goal of this clinical trial is to investigate the safety and effectiveness of cochlear implantation in infants and toddlers with single-sided deafness.
- Conditions
- Single Sided Deafness, Unilateral Deafness, Hearing Loss, Unilateral, Hearing Loss
- Trial name
- Little SSD (NCT05775367)
- Testing
- Cochlear Implant
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Down Syndrome
Efficacy of Rivastigmine in Patients With Down Syndrome
This study is to understand the efficacy on language and cognitive function in Down syndrome patients who take Rivastigmine.
- Trial name
- NCT00748007
- Testing
- Rivastigmine
- Where
- Taiwan
- Volunteers
- 14 people
- Sponsor
- National Taiwan University Hospital
Cerebral Palsy, Neurological Conditions
Safety and Efficacy Study of Oral Glycopyrrolate Liquid for the Treatment of Pathologic (Chronic Moderate to Severe) Drooling in Pediatric Patients 3 to 18 Years of Age With Cerebral Palsy or Other Neurologic Conditions
This is an open-label clinical research study of an oral glycopyrrolate liquid for the treatment of chronic moderate to severe drooling in patients with cerebral palsy or other neurological conditions.
- Conditions
- Cerebral Palsy, Neurological Conditions, Mental Retardation, Sialorrhea
- Trial name
- NCT00491894
- Testing
- Oral Glycopyrrolate Liquid
- Where
- 7 sites in United States
- Volunteers
- 137 people
- Sponsor
- Shionogi
Down Syndrome
Effects of (tDCS) Combined With Virtual Reality Versus CPT on Brain, Cognitive, and GMS in Children With DS.
This randomized controlled trial aims to compare the effects of transcranial direct current stimulation (tDCS) combined with virtual reality-based training versus conventional physical therapy on brain activity, cognitive…
- Trial name
- NCT07385066
- Testing
- Conventional Physical Therapy, Experimental group (tDCS + Virtual Reality)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Superior University
Disorder of Consciousness
Hydrocephalus Treatment on Persistent Disorder of Consciousness
After acute brain injury or haemorrhagic stroke, hydrocephalus might participate to consciousness disorder. We plan to explore whether ventriculoperitoneal shunt insertion improves consciousness in patients with vegetative or…
- Trial name
- HYCO (NCT05219331)
- Testing
- Ventriculoperitoneal shunt
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Sciatica
Neuraxial Pethidine After Lumbar Surgery Trial
The hypothesis is that epidural pethidine is an effective form of pain relief following lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered (intravenous) patient-controlled analgesia (PCA)…
- Trial name
- NCT00163553
- Testing
- Pethidine
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Austin Health
Dyslexia, Specific Learning Disability
Efficacy of rTMS as an Adjunct to AI Enabled Remedial Intervention in Children With Dyslexia
Dyslexia is the most common neurobehavioral disorder affecting children, with prevalence rates ranging from 17.5% to 21%. Studies have shown incomplete response to remediation and behavioural therapies in children with dyslexia.
- Conditions
- Dyslexia, Specific Learning Disability, Transcranial Magnetic Stimulation
- Trial name
- NCT05923645
- Testing
- Transcranial magnetic stimulation (Hf rTMS)
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Hemorrhoidectomy, Postoperative Analgesia
The Impact of Methylene Blue on the Quality of Recovery in Patients Undergoing Hemorrhoidectomy
Classical hemorrhoidectomy is known to be linked with significant postoperative pain, which can result in patient discomfort, extended hospital stays, and increased costs.
- Trial name
- NCT06747195
- Where
- 3 sites in China
- Volunteers
- 290 people
- Sponsor
- Qilu Hospital of Shandong University
Analgesia
Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia
Cesarean birth is a common surgical procedure. After cesarean birth, postsurgical pain may delay recovery, interfere with maternal-newborn bonding, and reduce the breastfeeding if not adequately controlled.
- Trial name
- TAB (NCT05785377)
- Testing
- Bupivacaine-Neostigmine, Bupivacaine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Mansoura University
Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke
Evaluation of Consciousness by Brain-computer Interface in Severely Brain Damaged Patients
The objective of this study is to show that the measurement of auditory and vibro-tactile evoked potentials, or the recording of the EEG signal during a motor imaging task, can be used in routine clinical situations to explore…
- Conditions
- Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke, Brain Hypoxia
- Trial name
- AWAKE (NCT03998930)
- Testing
- Clinical evaluation of consciousness by the Coma Recovery Scale Revised (CRS-R)
- Where
- 4 sites in France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Fragile X Syndrome
AFQ056 for Language Learning in Children With FXS
The purpose of this clinical trial is to investigate the impact of AFQ056 on language learning in 3-6 year old children with Fragile X Syndrome (FXS).
- Trial name
- FX-LEARN (NCT02920892)
- Testing
- AFQ056, Language Intervention
- Where
- 14 sites in United States
- Volunteers
- 110 people
- Sponsor
- Elizabeth Berry-Kravis
Age-related Cognitive Decline, Computers, Handheld
Interest of Two Digital Devices for the Diagnosis of Neurocognitive Disorders in Elderly People With Cognitive Symptoms.
The goal of this clinical trial is to compare conventional clinical data collected as part of usual practice with data collected by the two digital tools to help diagnose major and minor neurocognitive disorders in elderly people…
- Conditions
- Age-related Cognitive Decline, Computers, Handheld, Neurocognitive Disorders
- Trial name
- NCT06032611
- Testing
- COGNUM_ALZVR
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- RIVAGES
Phantom Limb Pain, Phantom Pain
Study of Phantom Limb Pain Using Peripheral Nerve and Spinal Cord Stimulation
The purpose of this study is to evaluate the effectiveness of neuromodulation for relief of phantom limb pain (PLP) using peripheral nerve (PNS) and spinal cord (SCS) stimulation with implantable electrodes.
- Conditions
- Phantom Limb Pain, Phantom Pain, Amputation
- Trial name
- NCT05650931
- Testing
- Implantation of PNS electrodes during surgery, mapping to select sites with the best effect and pain modulation., SCS electrode implantation at surgery, mapping to select sites with the best effect and pain modulation., EEG to search for phantom pain biomarkers
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Artur Biktimirov
Delirium, Sleep Fragmentation
Direct Noise Reduction in the Intensive Care Units (ICU) Using Earplugs and Noise Canceling Headphones
This study seeks to examine the effects of overnight noise reduction in critically ill patients who are receiving mechanical ventilation.
- Trial name
- NCT01343095
- Testing
- Foam Earplugs, Noise Canceling Headphones
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University
Musculoskeletal, Pain Management
Life-Style Medicine for Chronic Musculoskeletal Pain in Older People
The goal of this clinical trial is to determine the clinical effectiveness of lifestyle medicine in reducing chronic musculoskeletal pain in older adults, as measured by pain intensity, pain interference, self-management…
- Conditions
- Musculoskeletal, Pain Management, Chronic Pain, Musculoskeletal Pain
- Trial name
- lifestyle med (NCT07194239)
- Testing
- Lifestyle medicine Health coaching
- Where
- Hong Kong
- Volunteers
- 268 people
- Sponsor
- Chinese University of Hong Kong