Clinical trials: Neurobiological
Major Depressive Disorder, Substance Use Disorder
Defining Neurobiological Links Between Substance Use and Mental Illness
Background: Nicotine dependence leads to about 480,000 deaths every year in the United States. People with major depressive disorder (MDD) are twice as likely to use nicotine compared to the general population.
- Conditions
- Major Depressive Disorder, Substance Use Disorder, Normal Physiology
- Trial name
- NCT05538910
- Testing
- Nicotine Patch
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Mental Retardation, Stereotyped Behavior
Repetitive Behavior Disorders in People With Severe Mental Retardation
Repetitive behavior disorders are prevalent among people with severe mental retardation. These disorders can interfere significantly with an individual's daily functions.
- Conditions
- Mental Retardation, Stereotyped Behavior, Self-Injurious Behavior, Compulsive Behavior
- Trial name
- NCT00491478
- Testing
- sertraline
- Where
- 2 sites in United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Unrecognized Condition
Deep Diaphragmatic Breathing: Neurobiological and Anti-inflammatory Effects
The exposure to acute and\or chronic stress can produce an activation of sympathetic nervous system (SNS), leading to an increased level of cortisol and pro-inflammatory cytokines.
- Trial name
- NCT04102813
- Testing
- Functional Therapy
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Alcohol Use Disorder (AUD), Alcohol Abuse
Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder
Background: Alcohol Use Disorder (AUD) is a complex psychiatric disorder, involving several brain areas and neurocircuits. Transcranial Direct Current Stimulation (tDCS) allows to stimulate superficial areas of brain using a weak…
- Conditions
- Alcohol Use Disorder (AUD), Alcohol Abuse, Alcohol Dependence, Alcohol-Related Disorders
- Trial name
- NCT04897295
- Testing
- Active transcranial Direct Current Stimulation
- Volunteers
- 30 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Panic Disorder
Neurobiological Mechanisms in Panic Disorder
This study will examine brain and noradrenaline function in panic disorder. Noradrenaline is a brain chemical that is involved in the regulation of emotion, anxiety, sleep, stress hormones such as cortisol, and other body…
- Trial name
- NCT00103987
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bulimia Nervosa
Neurobiological and Psychological Maintenance Mechanisms Associated With Anticipatory Reward in Bulimia Nervosa
The purpose of this investigation is to identify the potentially crucial role of anticipatory reward mechanisms maintaining bulimic behavior (i.e., binge eating and purging) in bulimia nervosa (BN).
- Trial name
- NCT04917068
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenia, Schizo Affective Disorder
REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)
The purpose of this study is to understand how different types of community-based mental health care affect thinking abilities, daily functioning, and brain activity in adults with schizophrenia and related conditions.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizophreniform Disorders
- Trial name
- NCT07006935
- Testing
- Clubhouse Model of Psychosocial Rehabilitation for Serious Mental Illness, Usual Community-Based Mental Health Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Western Reserve University
Depression
Study on Allopregnanolone and Depression in Perimenopausal Women
This study aims to identify how the progesterone metabolite allopregnanolone affects behavior and neurobiology that may underlie perimenopausal depression.
- Trial name
- NCT05329779
- Testing
- brexanolone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
FM and PTSD
Neurohormonal Benefits of Exercise in Fibromyalgia and PTSD
The most recent conflicts are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions, including Fibromyalgia (FM), from…
- Trial name
- EXFMPTSD (NCT03236467)
- Testing
- Progressive Exercise Training
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Monoamine Transporter Genes, Environmental Factors
Multimodal Neurobiological Approaches to Explore the Gene-Environment Interactions in ADHD
Previous studies have demonstrated significant associations of attention-deficit hyperactivity disorder (ADHD) with monoamine transporter genes, including dopamine transporter gene (DAT1), norepinephrine transporter gene…
- Trial name
- NCT04571125
- Where
- 2 sites in Taiwan
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obsessive-Compulsive Disorder, Social Anxiety Disorder
Neurobiological Markers of Treatment Response for Anxiety and OCD
Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided.
- Conditions
- Obsessive-Compulsive Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT05663489
- Testing
- Bergen 4-Day Treatment (B4DT)
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Major Depressive Disorder
Neurobiological Effects of Light on MDD
The primary study objective is to observe/measure the circadian pattern of sleep, Cortisol and Melatonin in MDD subjects and Control subjects.
- Trial name
- NCT02940769
- Testing
- light glasses
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Nicotine Dependence
Nicotine Withdrawal Symptoms and Smoking Relapse
Background: Smoking is thought to cause changes in the brain that lead to addiction and craving. Smokers who try to quit experience nicotine withdrawal symptoms that include irritability, anxiety, and difficulty concentrating.
- Trial name
- NCT01511614
- Testing
- Transcranial Direct Current Stimulation, Nicotine patch, Varenicline Pill
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Suicidal Ideation, Suicide Attempt
Neural Correlates of Suicidal Behavior in Youth
This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and…
- Conditions
- Suicidal Ideation, Suicide Attempt, Suicidal Behavior, Depression / Major Depressive Disorder
- Trial name
- NCT07568054
- Testing
- CAMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Major Depressive Disorder
Cognitive Reappraisal in Adolescents With Major Depression
Major depression (MD) is common during adolescence and associated with significant morbidity and mortality. One important factor for the development and maintenance of adolescent MD are disturbances in emotion regulation…
- Trial name
- KONNI (NCT03957850)
- Testing
- Cognitive Reappraisal Training, Control Training
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Stress Reaction
Predictive Elements of Trauma and Its After-effects: Importance of the Quality of Neurobiological Response to Stress
The neurobiological response to stress is an adaptive response allowing us to cope with the multiple aggressions of daily life. This response orchestrates the body's systemic reaction.
- Trial name
- LIFT-UP (NCT04530214)
- Testing
- Blood collection, Saliva collection, Electrocardiography (ECG)
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- Direction Centrale du Service de Santé des Armées