Clinical trials: Neurocognition, open to volunteers
Psychiatric Disorders, Depression - Major Depressive Disorder
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Psychiatric conditions are each defined by different set of symptoms, however, they often share common characteristics such as impairments in cognitive and social functioning.
- Conditions
- Psychiatric Disorders, Depression - Major Depressive Disorder, Schizophrenia and Other Psychotic Disorders, Anxiety and Mood Disorders
- Trial name
- NCT07506070
- Testing
- Action-Based Cognitive Remediation
- Volunteers
- 160 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Ischemic Stroke, Cognitive Impairment
Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke
The purpose of this study is to determine whether a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), combined with traditional cognitive therapy will improve cognitive function in patients…
- Trial name
- TRAINS (NCT04897334)
- Testing
- tDCS, Cognitive Therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pennsylvania
Primary Brain Tumor, Glioma
Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients
In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain.
- Conditions
- Primary Brain Tumor, Glioma, Meningioma, Schwannoma
- Trial name
- NCT05576103
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Jona Hattangadi-Gluth
Carotid Artery Diseases, Neurocognitive Dysfunction
Assessing Neurocognition After Cerebrovascular Intervention
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain.
- Trial name
- NCT03344276
- Testing
- Neurocognitive Assessments, Measurements of inflammatory biomarkers, Carotid Artery Stenting
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Primary Brain Tumors, Diffuse Glioma
Proton Versus Photon Radiotherapy in Adults With Primary Brain Tumors
This study will be done in adults with brain tumors having good prognosis requiring treatment with radiotherapy. The current practice for brain radiotherapy involves treatment using X rays (photon radiotherapy).
- Conditions
- Primary Brain Tumors, Diffuse Glioma, Meningioma, Pituitary Adenoma
- Trial name
- PRIDE (NCT06831461)
- Testing
- Proton Beam Therapy, Photon Radiotherapy
- Where
- India
- Volunteers
- 156 people
- Sponsor
- Tata Memorial Centre
Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the brain.
- Conditions
- Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease
- Trial name
- NCT03568669
- Testing
- NIH Toolbox Cognition Battery
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Down Syndrome
Down Syndrome, Physical Activity and Sleep Apnea
To realize a sleep phenotyping in a population with Down syndrome, its determinants, and the consequences of these disorders, with a specific focus on sleep apnea syndrome.
- Trial name
- TAPAS (NCT06061562)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Brain Tumor, Pediatric
Irradiation in Paediatrics: Neurocognition, Neuroimaging and Evaluation of Memory and Attention
This is a prospective, open-label, multicentric study designed to correlate the dose delivered to the hippocampus with declarative memory deficits 2 years after radiotherapy treatment in a paediatric population who had received…
- Trial name
- IPANEMA (NCT06599879)
- Testing
- Neuropsychological assessments:
- Where
- 14 sites in France
- Volunteers
- 130 people
- Sponsor
- Institut Claudius Regaud
Glioblastoma Multiforme, Adult, Glioblastoma or Gliosarcoma
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
The study aims to investigate the prognostic significance of olfactory function in patients with glioblastoma. We are examining olfactory function at various points during therapy and correlating the results with survival data.
- Conditions
- Glioblastoma Multiforme, Adult, Glioblastoma or Gliosarcoma, Glioblastoma, Adult
- Trial name
- OLFGBM (NCT06954636)
- Testing
- olfactory testing (threshold and identification test)
- Where
- 2 sites in Germany
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sied Kebir
Sepsis, ARDS
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation.
- Conditions
- Sepsis, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- ESTABLISH (NCT05591924)
- Testing
- Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cognitive Deficits, Mild
Microbiome-Targeted Enhancement of Neurocognition With Probiotics-Riboflavin Combination
This randomized, double-blind, placebo-controlled trial will evaluate whether 12 weeks of supplementation with the probiotic Lactobacillus rhamnosus GG combined with colon-delivered riboflavin will improve cognitive performance…
- Trial name
- MENTOR (NCT07410052)
- Testing
- Experimental 1, Experimental 2
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Center for Health Sciences, Serbia
Dementia
Large Language Model for Understanding and Monitoring Elderly Neurocognition
Dementia affects millions of people worldwide, and early diagnosis is essential for getting the right care and support. Doctors rely on collateral histories (accounts from family members or caregivers) to understand changes in a…
- Trial name
- LUMEN (NCT07347431)
- Testing
- LUMEN prototype software interaction
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Subclinical Atherosclerotic Cardiovascular Disease, Neurocognitive Decline
MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling
The MISTIC study is a non-profit, cross-sectional clinical research project aimed at investigating the relationship between atherosclerosis and both cardiovascular and cognitive function in adult populations.
- Trial name
- MISTIC (NCT07520643)
- Testing
- Peripheral Vascular Imaging, Coro-CT, Neurocognitive Assesment
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Psychotic Disorders, Schizophrenia
Examining the Efficacy of a Virtual Reality Cognitive Remediation Program for People Living With Psychosis
Individuals living with a psychotic disorder often experience changes to their thinking and social skills that can lead to challenges with work, school, relationships and living independently.
- Conditions
- Psychotic Disorders, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT05973110
- Testing
- Cognitive Remediation, Active Control
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Neurocognitive Dysfunction
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
The goal of this clinical trial is to evaluate the role of memantine in preservation of memory and neurocognition in patients undergoing craniospinal irradiation.
- Trial name
- MEMENTO (NCT06275035)
- Testing
- Memantine Oral Tablet
- Where
- India
- Volunteers
- 101 people
- Sponsor
- Tata Memorial Centre
Patient Discharge, Neurocognition
PACU Discharge Readiness
The use of custom-created apps, neuropsychological testing, and clinical assessments will be evaluated as tools for determining the appropriateness of PACU discharge to home.
- Conditions
- Patient Discharge, Neurocognition, Baseline
- Trial name
- NCT07588542
- Testing
- custom-created apps, neuropsychological testing, and clinical assessments
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Illinois Chicago
Sickle Cell Disease
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
This study will examine sleep disordered breathing and sleep quality in participants (ages 12-25) diagnosed with sickle cell disease of any genotype.
- Trial name
- NCT06477289
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- St. Jude Children's Research Hospital
Brain Metastases
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions using 3D conformal radiotherapy.
- Trial name
- NCT05045950
- Testing
- Memantine -Twice Daily or Extended Release, WBRT utilizing the PRDR technique
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Medical College of Wisconsin
Cognition, Cognition Disorders
Establishing Normal Cognitive Test Scores for Adults Using a Voice-Enabled Digital Testing Platform Across the Lifespan
Trial weblink: https://www.memoryexam.com/job/norms/ Participants enrolled in this study will complete a single-session, non-invasive, computerized cognitive assessment administered through a secure, web-based digital platform.
- Conditions
- Cognition, Cognition Disorders, Cognition - Other, Dementia
- Trial name
- NCT07763392
- Testing
- Voice-based Cognitive Testing
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Neurology Center of Southern California
Elderly (People Aged 65 or More), Neurocognition
Assessment of Informal Support Provided by Caregivers at Different Stages of Alzheimer's Disease
In France, approximately 1,200,000 people aged 65 and over suffer from Alzheimer's disease or related disorders, of which Alzheimer's disease (AD) accounts for 70% of cases. This prevalence could double by 2050.
- Conditions
- Elderly (People Aged 65 or More), Neurocognition, Alzheimer s Disease
- Trial name
- ICAD (NCT07409506)
- Testing
- " Ressources Utilisation in Dementia " (RUD) questionnaire.
- Where
- France
- Volunteers
- 312 people
- Sponsor
- Hospices Civils de Lyon