Clinical trials: Neurocognitive Decline
Postoperative Delirium
Risk Assessment for Postoperative Delirium
Postoperative delirium (POD) - a temporary state of confusion - is a frequent complication of surgery, which most commonly occurs in elderly patients.
- Trial name
- RAPID (NCT02377115)
- Testing
- Tablet computer application
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Kidney Diseases, Dementia
BRINK (BRain In Kidney Disease) Memory Study 2.0
In this study, the investigators will be looking at results of tests of memory and thinking and daily activities in a group of people without known chronic kidney disease (CKD) , and a group of CKD patients, and follow the…
- Conditions
- Chronic Kidney Diseases, Dementia, Dementia, Vascular, Stroke
- Trial name
- BRINK (NCT04975464)
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Anne Murray
Mild Cognitive Impairment, Early Alzheimer's Disease
Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease
The purpose of this study is to determine whether daily treatment with this new treatment approach, called COT would be effective in protecting the memory and brain regions of people who are already showing signs of memory loss.
- Conditions
- Mild Cognitive Impairment, Early Alzheimer's Disease, Memory Impairment
- Trial name
- NCT05122598
- Testing
- COT
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Evon Medics LLC
Multiple Sclerosis, Cognitive Decline
Computerized Cognitive Training in MS
WHO: 40 participants with a confirmed diagnosis of Multiple Sclerosis (MS) able to engage in moderate physical activity. WHY: The purpose of this study is to evaluate two computerized brain training tools, which include light…
- Trial name
- NCT03737825
- Testing
- Computerized gaming rehabilitation Program 1, Computerized gaming rehabilitation Program 2
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Delirium, Age-Related Cognitive Decline
Acute Care for Elders (ACE) Program at OHSU Hospital
The purpose of this investigation is to assess the effectiveness of a multi-disciplinary Acute Care for Elders (ACE) program dedicated to the care of patients age 70 and older admitted to Oregon Health \& Science University's…
- Conditions
- Delirium, Age-Related Cognitive Decline, Frail Elderly, Hospital Acquired Pressure Ulcer
- Trial name
- NCT02119078
- Testing
- Acute Care of Elders focused geriatric care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Mild Cognitive Impairment, Cognitive Decline
BreinZorg: Feasibility Study Into an Online Lifestyle Platform for MCI and SCD
Dementia is the most common disease in older individuals and this century's biggest healthcare challenge. Many patients who visit the memory clinic with memory complaints do not have dementia but instead are diagnosed with mild…
- Trial name
- NCT06309758
- Testing
- Breinzorg
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Metabolic Disorders and Cognitive Decline
Effects of Whole Grain Rye on Metabolic Risk Markers and Mood
The purpose of the study is to investigate, in healthy middle age subjects, effects of whole grain rye on cognitive functions, mood, and cardiovasculair risk markers
- Trial name
- NCT03275948
- Testing
- whole grain, reference
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lund University
Mobility, Depressive Symptoms
Effectiveness of AMICOPE Intervention to Maintain Self-Perceived Health and Intrinsic Capacity in Older People
In their day to day, persons do from simple to more or less complicated tasks and activities (ie: stand from a chair, open a door, shopping, read, drive, play chess, remind an appointment...).
- Conditions
- Mobility, Depressive Symptoms, Nutrition, Healthy, Cognitive Decline
- Trial name
- EFICIS (NCT05249504)
- Testing
- VIVIFRAIL, Nutrition, Psychology
- Volunteers
- 212 people
- Sponsor
- Fundacio Salut i Envelliment UAB
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Post-operative Cognitive Decline, Post-operative Delirium
Cardiac Surgery Neuroprotection Study in Elders
The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.
- Trial name
- CNS-Elders (NCT01561378)
- Testing
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Albert Einstein College of Medicine
Sleep Deprivation, Aging
The Peripheral Blood Multi-Omics Study on Sleep Loss
Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related…
- Conditions
- Sleep Deprivation, Aging, Alzheimer Disease, Healthy Lifestyle
- Trial name
- NCT06492109
- Testing
- Sleep manipulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns
This is an eight-week pilot research study designed to test whether simple changes to the bedroom environment along with brief sleep hygiene strategies, can improve sleep in older adults who live alone, have memory concerns, and…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Insomnia
- Trial name
- NCT07440498
- Testing
- Bedroom Environment Tailoring, Sleep Health Education
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Cognitive Decline
Evaluation of Cognitive State Using Neurosteer EEG System
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through EEG recordings while listening to an…
- Trial name
- NCT04386902
- Testing
- Neurosteer Aurora system
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neurosteer Ltd.
Alzheimer Disease, Mild Cognitive Impairment
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
There is a major unmet need for timely, non-invasive, and low-burden evaluation of patients presenting with mild cognitive impairment (MCI) and dementia.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognitive Decline
- Trial name
- QUIP II (NCT06025877)
- Testing
- PrecivityAD2(TM) blood test
- Where
- 9 sites in United States
- Volunteers
- 400 people
- Sponsor
- C2N Diagnostics
Myocardial Infarction, Unstable Angina
CORonary Diet Intervention With Olive Oil and Cardiovascular PREVention
The purpose of this study is to compare the effects of the consumption of two different dietary patterns (low fat versus Mediterranean Diet) on the incidence of cardiovascular events of persons with coronary disease.
- Conditions
- Myocardial Infarction, Unstable Angina, Malignancy, Cognitive Decline
- Trial name
- CORDIOPREV (NCT00924937)
- Testing
- Mediterranean Diet, Low Fat Diet
- Where
- Spain
- Volunteers
- 1,002 people
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Cognitive Decline, Heart Diseases
The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.
Decline in cognitive function after surgery occurs most commonly in older patients and patients undergoing major surgeries, such as heart surgery.
- Conditions
- Cognitive Decline, Heart Diseases, Delirium
- Trial name
- NCT03324867
- Testing
- Regular insulin, Normal Saline Flush, 0.9% Injectable Solution
- Volunteers
- 316 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Alzheimer Disease
Frailty Outcomes And Risk With Alzheimer's Related Dementia
The primary aim of this study is to investigate the association between frailty as defined by the Fried Frailty Phenotype and risk of functional decline in patients with Alzheimer's dementia.
- Trial name
- FORWARD (NCT06570109)
- Testing
- Frailty
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Aalborg University Hospital
Chronic Rhinosinusitis, Sleep Disorders
Sleep Disturbance and Daytime Fatigue as Predictors of Cognitive Decline and Functional Decline in Chronic Rhinosinusitis
FOCUS-CRS is a cross-sectional observational study examining the relationship between sleep disturbance, daytime fatigue, and cognitive and functional health in patients with chronic rhinosinusitis (CRS).
- Conditions
- Chronic Rhinosinusitis, Sleep Disorders, Fatigue, Cognitive Dysfunction
- Trial name
- SNOOZE-CRS (NCT07242040)
- Testing
- Self-Reported Questionnaires for Sleep, Fatigue, and Quality of Life
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Sinai University
Delirium, Postoperative Cognitive Dysfunction
Biomarkers Associated With Postoperative Cognitive Dysfunction
Loss of cognitive function after major surgery is a significant risk in older people. It can occur acutely in the days after surgery as delirium or in months to years later as a persistent reduction in brain function termed…
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- NCT05464355
- Testing
- Intraoperative electroencephalography recording, Neurofilament light chain measurement, Tau protein measurement
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Oxford
Cognitive Decline, Dementia
Group Reminiscence Therapy for Elderly People With Cognitive Decline in Institutional Context
The project presented here respond to this emerging need by implementing a Reminiscence Therapy program dedicated to elderly people in an institutional context.
- Conditions
- Cognitive Decline, Dementia, Cognitive Impairment
- Trial name
- NCT03370796
- Testing
- Reminiscence Therapy Program
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Escola Superior de Enfermagem de Coimbra