Clinical trials: Neurocognitive Decline
Intermittent Fasting, Pre Diabetes
Time Restricted Eating Plus Exercise for Weight Management
Time restricted eating (TRE) is currently the most popular form of intermittent fasting which involves confining the eating window to 8-10 hours (h) and fasting for the remaining hours of the day.
- Conditions
- Intermittent Fasting, Pre Diabetes, Cognitive Decline
- Trial name
- NCT05290233
- Testing
- TRE + Exercise
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Alzheimer Dementia, Statins
Statins, Cholesterol and Cognitive Decline in Alzheimer's
Disturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer's disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or…
- Trial name
- NCT06635252
- Testing
- STA 4783
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Karolinska Institutet
Cognitive Decline, Subjective Cognitive Impairment
Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance.
Introduction: The Insulin resistance itself has been recognized as an independent risk factor for dementia development. Insulin plays an important role in the regulation of muscle function and the processes of learning and…
- Conditions
- Cognitive Decline, Subjective Cognitive Impairment, Insulin Resistance
- Trial name
- NCT07284316
- Testing
- Turmeric extract
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Mexicano del Seguro Social
Cognitive Decline
Study Evaluating the Quality and Effects of Lion's Mane Product on Cognitive Health
The rationale for this study is to observe differences in cognitive health outcomes such as short term memory and simple reaction time between a consumer-grade and commercially available Lion's mane mushroom product and a placebo…
- Trial name
- NCT06870136
- Testing
- Lion's Mane Study Product
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- M2 Ingredients
Aging, Cognitive Decline
The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT)
Tremendous progress has been made in characterizing the interactions between the central nervous system and the gastrointestinal tract.
- Trial name
- COMBAT (NCT03679533)
- Testing
- Freeze-Dried Cranberry Powder
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Mild Cognitive Impairment, Exercise Training
Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults
In this research, a unique "Exergame" has been developed and is being tested. The Exergame consists of unique Virtual Reality Cognitive Training (VRCT) games combined with concurrent cycling on a recumbent stationary cycle.
- Trial name
- Exergames (NCT04311736)
- Testing
- Exergame, Cycling, Stretching
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Moai Technologies LLC
Vitamin D Deficiency, Cognitive Decline
High-dose Vitamin D Supplements in Older Adults
This Phase II randomized clinical trial aims to test if supplementation with high dose oral vitamin D will successfully correct vitamin D insufficiency, compared to treatment with standard (RDA) dose vitamin D in a diverse…
- Trial name
- NCT03613116
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of California, Davis
Alzheimer Disease, Early Onset, Alzheimer Disease
Study of Tolerability, Safety and Efficacy of Sensory Stimulation at Multiple Dose Levels to Improve Brain Function (Etude Study)
The Etude Study is a multi-center, four-arm prospective dose-adjusting study designed to assess the tolerability, safety and efficacy of non-invasive sensory stimulation for patients with cognitive impairment.
- Conditions
- Alzheimer Disease, Early Onset, Alzheimer Disease, Alzheimer Dementia, Mild Cognitive Impairment
- Trial name
- NCT03661034
- Testing
- GammaSense Stimulation System (non-invasive, non-significant risk)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cognito Therapeutics, Inc.
Alzheimer Disease, Alzheimer Disease 1
A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (HOPE Study)
This is a randomized, double-blind, sham-controlled pivotal study of sensory stimulation in subjects with mild to moderate AD. Up to approximately 670 subjects will be treated with either Active or Sham investigational device…
- Conditions
- Alzheimer Disease, Alzheimer Disease 1, Alzheimer Disease 2, Alzheimer Disease 3
- Trial name
- HOPE (NCT05637801)
- Testing
- Spectris™ AD - Active
- Where
- 68 sites in United States
- Volunteers
- 673 people
- Sponsor
- Cognito Therapeutics, Inc.
Traumatic Brain Injury, Mild Traumatic Brain Injury
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance.
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
- Trial name
- BRAIN-SPEED (NCT06217575)
- Testing
- Alpha neurofeedback training, Visual Attention Training
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD)
Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)
Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Despite improved procedural outcomes, neurocognitive complications such as postoperative delirium (POD) and postoperative…
- Conditions
- Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD), Delirium - Postoperative, Neurocognitive Disorders
- Trial name
- HVU-NEURO (NCT07626567)
- Volunteers
- 500 people
- Sponsor
- Heart and Brain Research Group, Germany
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns
This is an eight-week pilot research study designed to test whether simple changes to the bedroom environment along with brief sleep hygiene strategies, can improve sleep in older adults who live alone, have memory concerns, and…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Insomnia
- Trial name
- NCT07440498
- Testing
- Bedroom Environment Tailoring, Sleep Health Education
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Cerebral Small Vessel Diseases, Stroke
Stopping Cognitive Decline and Dementia by Fighting Covert Cerebral Small Vessel Disease
Cerebral small Vessel Disease (cSVD), characterized by an alteration of the structure and function of small penetrating brain arteries, is highly prevalent in older persons from the general population and represents a leading…
- Conditions
- Cerebral Small Vessel Diseases, Stroke, Dementia
- Trial name
- SHIVA (NCT05306834)
- Testing
- Retinal Imaging, Blood sample, Evaluation of cardiovascular risks
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Bordeaux
Aging, Mild Cognitive Impairment
Internet-based Conversational Engagement Clinical Trial
The study aims to randomize 320 (160 Caucasian, 160 African American) socially isolated adults 75+ years old (50:50 split between those with normal cognition and mild cognitive impairment (MCI)) recruited from the community to…
- Trial name
- I-CONECT (NCT02871921)
- Testing
- Conversational Engagement
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognitive Decline, Dementia
Group Reminiscence Therapy for Elderly People With Cognitive Decline in Institutional Context
The project presented here respond to this emerging need by implementing a Reminiscence Therapy program dedicated to elderly people in an institutional context.
- Conditions
- Cognitive Decline, Dementia, Cognitive Impairment
- Trial name
- NCT03370796
- Testing
- Reminiscence Therapy Program
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Escola Superior de Enfermagem de Coimbra
POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Heart Rate Variability
Predicting Postoperative Delirium With Heart Rate Variability Obtained by Analgesia Nociception Index
The aim of this pilot study is to establish a correlation between perioperative heart rate variability (HRV) as an expression of the shift in the balance of the autonomic nervous system and the occurrence of postoperative…
- Conditions
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Heart Rate Variability, Biomarkers
- Trial name
- DANI (NCT06709482)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Cognitive Dysfunction, Cognitive Disorder
Effects of Video Games and Ball Tossing on Eye Hand Coordination in Elderly With Mild Cognitive Impairment.
One of the key challenges faced by individuals with mild cognitive impairment (MCI) is the decline in cognitive and motor abilities, particularly eye-hand coordination (EHC), which is essential for performing daily activities and…
- Conditions
- Cognitive Dysfunction, Cognitive Disorder, Cognitive Decline
- Trial name
- NCT07182396
- Testing
- Experimental Group, Control Group
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Aging, Cognitive Decline
Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition
Extended bouts of periodic mastication and intermittent energy restriction (IER) may improve cognitive performance in the context of adult hippocampal neurogenesis in an ageing population.
- Trial name
- ChANgE (NCT03457870)
- Testing
- Intermittent Energy Restriction, Chewing, Chewing + Intermittent Energy Restriction
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- King's College London
Age-related Memory Disorders, Mood Disorders
Omega-3 and Blueberry Supplementation in Age-Related Cognitive Decline
The aim of this study is to determine the efficacy of 6 months' dietary supplementation with omega-3 fatty acids and whole freeze dried blueberry powder in improving cognition in older adults.
- Trial name
- NCT01746303
- Testing
- Omega-3 fatty acid, Blueberry powder
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Alzheimer's Disease
Brain Aging Project--Kansas University
The purpose of this study is to determine the effects of exercise and cardiorespiratory fitness on age-related brain changes.
- Trial name
- NCT00267124
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center