Clinical trials: Neurocognitive Decline
Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment and Psychopathology
Mild Cognitive Impairment (MCI) is a condition characterized by cognitive deterioration greater than what is expected from normal aging, representing an important risk factor for the development of dementia.
- Trial name
- MIND (NCT07358962)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Aging, Cognitive Decline
Aging and Cognitive Health Evaluation in Elders (ACHIEVE)
The ACHIEVE study will be a randomized controlled trial nested within the infrastructure of the Atherosclerosis Risk in Communities (ARIC) study.
- Trial name
- ACHIEVE (NCT03243422)
- Testing
- Successful aging health education intervention, Hearing intervention
- Where
- 4 sites in United States
- Volunteers
- 977 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Heart Failure, Cognitive Impairment
Reducing Cognitive Impairment by Management of Heart Failure as a Modifiable Risk Factor
This study will test the feasibility and effectiveness of an innovative model of care for cognitively impaired patients with heart failure.
- Conditions
- Heart Failure, Cognitive Impairment, Dementia, Left Ventricular Dysfunction
- Trial name
- Cog-HF (NCT06088212)
- Testing
- Disease management program
- Where
- Australia
- Volunteers
- 168 people
- Sponsor
- Baker Heart and Diabetes Institute
Mild Cognitive Disorder
Study on the Effect of Online Cognitive Training Doses on Cognitive Function in Individuals With Mild Cognitive Decline
The primary questions that this clinical trial aims to answer are: To compare the differences in the efficacy of different doses of Computerized Cognitive Training (CCT) in improving cognitive function among patients with Mild…
- Trial name
- NCT07213362
- Testing
- Computerized Cognitive Training
- Volunteers
- 234 people
- Sponsor
- Peking University
Cognitive Decline
Anxiety Related to the Diagnosis of Alzheimer's Disease or Related Diseases
Improving the diagnosis of neurocognitive disorders is a major public health challenge. This diagnosis occurs too late in the majority of cases, or is even sometimes non-existent for some despite the presence of clinical signs…
- Trial name
- ADIMA (NCT04342520)
- Testing
- Dyads Patient / caregiver
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Hospices Civils de Lyon
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Age-related Hearing Loss, Cognitive Decline
Auditory-Cognitive Dual-Task Intervention for Older Adults With Hearing Loss
Background: Age-related hearing loss (ARHL) is a common and irreversible condition that has been recently associated with cognitive decline and dementia. Hence, if ARHL is treated earlier, the risk of dementia might decrease.
- Conditions
- Age-related Hearing Loss, Cognitive Decline, Loneliness, Social Isolation
- Trial name
- NCT06486285
- Testing
- Auditory-cognitive dual-task training (ACDT)
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Atherosclerosis, Cognitive Decline
Advancing Postmenopausal Preventive Therapy
Advancing Postmenopausal Preventive Therapy (APPT) is a randomized, double-blinded, placebo-controlled trial designed to determine the effects of tissue selective estrogen complex (TSEC) therapy on the progression of subclinical…
- Trial name
- APPT (NCT04103476)
- Testing
- Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Lifestyle, Cognitive Decline
Brain-Health Lifestyle Restructuring Intervention
With population aging, the number of older persons with cognitive impairments increases. Literature support the effectiveness of a lifestyle approach to promote the health of persons with cognitive impairment, as well as a…
- Conditions
- Lifestyle, Cognitive Decline, Aging
- Trial name
- NCT04576624
- Testing
- Lifestyle Intervention, social activity
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- National Cheng Kung University
Postoperative Delirium, Elderly Patient
Diagnosis, Incidence and Consequences of PACU-Delirium
This study aims to 1. determine sensitivity and specificity of the Confusion Assessment Method for Postanesthesia Care Unit (CAM-PACU) 2.
- Conditions
- Postoperative Delirium, Elderly Patient, Cognitive Decline
- Trial name
- PADE-DIC (NCT04978870)
- Where
- Germany
- Volunteers
- 450 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Hypoxic Tolerance
This WP specifically aims to elucidate the effects of IEK on hypoxic tolerance and the development and severity of AMS symptoms, blood and tissue oxygenation status, as well as sleep quality during an episode of acute exposure to…
- Trial name
- NCT05588427
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Brain Neoplasm
MRI and Blood Biomarkers for the Prediction of Neurocognitive Decline Following Brain Radiation
This study determines whether non-invasive evaluation using repeated magnetic resonance imaging (MRI) scans and repeated blood biomarker measurements can be used to predict changes in a person's mental functions that result from…
- Trial name
- NCT05087888
- Testing
- Biospecimen Collection, Magnetic Resonance Imaging, Multiparametric Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
Aging, Cognitive Decline
The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT)
Tremendous progress has been made in characterizing the interactions between the central nervous system and the gastrointestinal tract.
- Trial name
- COMBAT (NCT03679533)
- Testing
- Freeze-Dried Cranberry Powder
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Sanfilippo Syndrome Type A, Sanfilippo Syndrome Type B
Neurobehavioral Phenotypes in MPS III
Hypothesis #1: Factor analysis of the revised Sanfilippo Behavior Rating Scale (SBRS) will identify a group of externalizing behaviors and a group of Klüver-Bucy syndrome-like behaviors as two different factors that are at least…
- Conditions
- Sanfilippo Syndrome Type A, Sanfilippo Syndrome Type B, Hurler Syndrome
- Trial name
- NCT01873911
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Obstructive Sleep Apnea, Cognitive Decline
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from…
- Trial name
- ESSENTIAL (NCT05988385)
- Testing
- Positive airway pressure, Oral appliance therapy, Positional therapy
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- California Pacific Medical Center Research Institute
Parkinson Disease, Orthostatic Hypertension
Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in PD
The goal of clinical trial is to learn about how blood pressure fluctuations affect cognitive performance (thinking abilities) and brain blood flow in persons with Parkinson's disease with and without orthostatic hypotension (low…
- Conditions
- Parkinson Disease, Orthostatic Hypertension, Cognitive Change, Cognitive Impairment
- Trial name
- NCT06252376
- Testing
- Head-up tilt table
- Sponsor
- University of California, San Diego
Alzheimer Disease, Cognitive Decline
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
Alzheimer's disease (AD) neuropathology is characterized by deposits of insoluble amyloid β-peptide (Aβ) in extracellular plaques and aggregated tau protein, which is found largely in the intracellular neurofibrillary tangles.
- Trial name
- (PENSA) (NCT03978052)
- Testing
- EGCG, Healthy lifestyle recommendations, Multimodal lifestyle intervention
- Where
- 2 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention and Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- Quest-Tablet (NCT05625425)
- Testing
- LabyrinthVR software, Labyrinth Tablet software, Labyrinth VR wireless
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alzheimer Disease, Memory Loss
Home-based Brain Stimulation for Memory
The proposed project aims to systematically examine the feasibility of remote, caregiver-led tACS for older adults who are vulnerable to memory decline.
- Trial name
- MemStim-home (NCT04783350)
- Testing
- Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Dementia, Cognitive Decline
Choral Singing For the Prevention of Dementia
To evaluate the efficacy of choral singing in the prevention of dementia and examine the underlying mechanisms using Magnetic Resonance Imaging (MRI) technique and a panel of peripheral biomarkers in venous blood and urine.
- Trial name
- NCT02919748
- Testing
- Choral Singing, Health Education Program
- Where
- Singapore
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National University of Singapore