Clinical trials: Neurodegeneration
Rare Diseases
European Registry on Rare Neurological Diseases
The recent implementation of European Reference Networks for Rare Diseases (ERNs) is an unprecedented move to improve the care of patients suffering from rare health disorders by transnational collaboration.
- Trial name
- ERN-RND reg (NCT04319796)
- Testing
- Data set as defined by the ERN Research Workgroup of the European Commission
- Volunteers
- 5,000 people
- Sponsor
- University Hospital Tuebingen
Glymphatic System, Neurodegeneration
Acute Effects of Vigorous-intensity Aerobic Exercise on Glymphatic Flow in Healthy Adults
This study investigates changes in glymphatic flow in the brain acutely after vigorous-intensity steady-state aerobic exercise. Twenty subjects (10 male and 10 female) perform 25 minute submaximal cycle ergometry exercise and the…
- Trial name
- GLYMREG (NCT04255758)
- Testing
- Cycle Ergometer Exercise
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Alzheimer Disease, Mild Cognitive Impairment
Study to Understand Novel Biomarkers in Researching Dementia
The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- SUNBIRD (NCT06547099)
- Testing
- Clinical tau PET, Clinical amyloid test, Research blood collection
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
ALS (Amyotrophic Lateral Sclerosis)
Developing a Comprehensive Biomarker Panel for Monitoring Progression and Early Detection in ALS Patients
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease for which reliable biomarkers for early diagnosis, prognosis, and patient stratification remain limited.
- Trial name
- UNZUELUZON ALS (NCT07737977)
- Testing
- peripheral venous blood collection, collection of medical data related to patient care
- Where
- 2 sites in France, Spain
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Neurodegeneration, Inflammation
The Effects of the MIND Diet on Oxidative Stress, Inflammation and Neurodegenerative Risk Biomarkers
American football is a high-contact sport, also known as a collision sport. American football players are exposed to various magnitudes and frequencies of head impacts throughout the season.
- Conditions
- Neurodegeneration, Inflammation, Oxidative Stress, Diet, Healthy
- Trial name
- NCT05982860
- Testing
- MIND diet
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bartu Eren Güneşliol
CANVAS Syndrome
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS
CANVAS (Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome), also referred to as RFC1-ataxia, is a recently molecularly characterized neurodegenerative disorder caused by a biallelic expansion of an AAGGG…
- Trial name
- INSIDE-CANVAS (NCT07156214)
- Testing
- Assessment of markers of oxidative stress in peripheral blood samples
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Anxiety, Microbiome
Microbiome, Anxiety and Cognitive Orientation Study
Mounting evidence shows that the gut microbiome plays an important role in communication within the gut-brain axis. However, the relationship between gut microbiota and their influence on anxiety is still not fully understood.
- Conditions
- Anxiety, Microbiome, Mood Disorders, Neurodegeneration
- Trial name
- MACO (NCT05388630)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Endominance
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis Relapse
Evaluation of Relapse Presence in Multiple Sclerosis
Purpose: This study aims to investigate the demonstrability of increased inflammation and neurodegeneration in multiple sclerosis (MS) patients in relapse period compared to MS patients in remission by cross-sectional analysis of…
- Trial name
- NCT05218317
- Testing
- in-vivo Corneal Confocal Microscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Marmara University
Multiple Sclerosis, Relapsing-Remitting Multiple Sclerosis
PET with [18F]Flumazenil As an Index of Neurodegeneration in MS
Beyond white matter pathology, grey matter damage is considered as a key player in disability onset and progression in Multiple Sclerosis (MS).
- Trial name
- FLUMA-SEP-T (NCT03825601)
- Testing
- PET with [11C]Flumazenil
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson's Disease
Biomarkers of Neurodegeneration and Neuroplasticity in Parkinson's Disease Patients Treated by Bilateral M1-iTBS
Intermittent theta-burst stimulation (iTBS) is a promising therapeutic option for Parkinson's disease patients. A study involving 24 patients will assess its effectiveness in alleviating clinical deficits.
- Trial name
- NCT06840145
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Wolfram Syndrome
I-Tracking Neurodegeneration in Early Wolfram Syndrome
Wolfram syndrome (WFS; OMIM #222300) is a rare autosomal recessive disease clinically defined in 1938 as the combination of childhood-onset insulin dependent diabetes, optic nerve atrophy, diabetes insipidus and deafness.
- Trial name
- I-TRACK (NCT03951298)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Washington University School of Medicine
Parkinson's Disease
Early Parkinson's Disease Monotherapy With CVN424
This is a multicenter, 12-week, placebo-controlled clinical trial of CVN424 150 milligrams (mg) tablets in early, untreated Parkinson's Disease (PD).
- Trial name
- NCT06006247
- Testing
- CVN424 150 mg
- Where
- 42 sites in United States
- Volunteers
- 64 people
- Sponsor
- Cerevance Beta, Inc.
Caregiver Burden, Caregiver Stress
Self-Care Training for Family Caregivers of Persons With Neurodegeneration
The purpose of this study is to assess whether an 8-week mindfulness program enhances psychological well-being (e.g., stress, depressive symptoms), biological indicators of stress (e.g., inflammation), and cognitive function…
- Trial name
- MCP (NCT06200909)
- Testing
- Mindfulness Meditation, Psychoeducation, Wait list control
- Where
- Canada
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Cortico Basal Degeneration, Corticobasal Syndrome
Imaging Studies in Corticobasal Syndrome
The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other.
- Conditions
- Cortico Basal Degeneration, Corticobasal Syndrome, Corticobasal Syndrome(CBS), Corticobasal Degeneration
- Trial name
- I-CAN (NCT07000851)
- Testing
- C-11 ER176 Radiotracer, C-11 PiB, AV1451 Tau
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jennifer Whitwell
Niemann-Pick Disease, Type C1
Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease
Background: Hydroxypropyl beta cyclodextrin (HPBCD) is being tested for a disease called Niemann-Pick disease type C1 (NPC1). NPC1 is a genetic disorder that results in gradual loss of nervous system function.
- Trial name
- NCT01747135
- Testing
- VTS-270
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Vtesse, LLC, a Mallinckrodt Pharmaceuticals Company
Glaucoma Associated With Other Ocular Disorders, Retina Disorder
AOSLO Imaging for the Study of Cellular Alterations in Retinal Neurodegeneration
Primary objective: Acquisition and analysis of images for non-medical purposes using the MONA IV system, an adaptive-optics-corrected scanning ophthalmoscope.
- Trial name
- RETION (NCT07725055)
- Testing
- MONA Imaging System
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Amyotrophic Lateral Sclerosis
The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)
The purpose of the study is to investigate the effects of memantine in ALS patients using functional outcome measures.
- Trial name
- NCT00409721
- Testing
- Memantine
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Amphetamine Addiction, Pharmacotherapy
Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction
The investigators will conducted a randomized double-blind placebo-controlled study to investigate the treatment outcomes of add-on low dose dextromethorphan (DM), memantine (MM), or dextromethorphan and memantine combination…
- Trial name
- NCT04687566
- Testing
- Dextromethorphan, Memantine, Dextromethorphan and memantine
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Diabetic Retinopathy, Neurodegeneration
Retinal Neurodegenerative and Vascular Changes in Diabetic Patients
Using Optical Coherence Tomography and ImageJ software the investigators will analyze retinal and choroidal vascular changes and their impact on retinal layers among patients with diabetes without retinopathy and patients with…
- Trial name
- NCT04637217
- Testing
- Optical Coherence Tomography
- Where
- Romania
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Neurodevelopmental Disorders, Autism Spectrum Disorder
Patterns of Neurodevelopmental Disorders
The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder, Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection, Pediatric Acute-Onset Neuropsychiatric Syndrome
- Trial name
- NCT06213090
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Richard Frye