Clinical trials: Neurodevelopmental Delay
Williams Syndrome, Child
Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams Syndrome
This study focuses on therapeutic targets for cognitive, motor, and social impairments in Williams syndrome by reversing brain myelin defects caused by GTF2I.
- Conditions
- Williams Syndrome, Child, Neurodevelopmental Delay
- Trial name
- NCT06315699
- Testing
- Clemastine Fumarate Tablets, corn starch tablets
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Qilu Hospital of Shandong University
Autism Spectrum Disorder, Developmental Delay
MAP Autism Prediction Study
This pilot clinical trial tests the hypothesis that certain blood metabolite levels can be used to predict Autism Spectrum Disorder (ASD).
- Trial name
- MAP (NCT04672967)
- Testing
- BioROSA MAP test
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- BioROSA Technologies Inc
Attention-Deficit Hyperactivity Disorder (ADHD)
A Study of Delayed and Extended Release Formulation of Dextroamphetamine Sulfate (HLD100) in Children With ADHD
The phase 2 study will evaluate the safety, tolerability and efficacy of HLD100 at steady state (following up to 5 weeks of treatment) in children using an outpatient, single-center, open-label, flexible dose-escalation study…
- Trial name
- HLD100-103 (NCT02884544)
- Testing
- HLD100
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Ironshore Pharmaceuticals and Development, Inc
Development Delay, Social Skills
Home-Based Social Skills Intervention for Young Children With Developmental Delays
The goal of this clinical trial is to learn about how parent training can be used to teach a social skills intervention for their young child with developmental delays.
- Conditions
- Development Delay, Social Skills, Parents
- Trial name
- NCT06184243
- Testing
- Parent Training, Video Modeling
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Prematurity, Development Delay
Maternal Voice and Quantitative EEG (qEEG)
A short-term randomized, blinded placebo-controlled trial, in premature infants in the neonatal intensive care unit (NICU) at 33-35 weeks post-conceptional age, of recorded maternal voice on quantitative EEG (spectral power…
- Conditions
- Prematurity, Development Delay, Premature Birth
- Trial name
- NCT05391633
- Testing
- Recorded Maternal Voice
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of New Mexico
Global Developmental Delay
Workshops for Children With Global Developmental Delays
To investigate the therapeutic effects of family workshops on children with global developmental delays and their parents by the analysis of the previously conducted workshops.
- Trial name
- NCT05418933
- Testing
- Family workshop
- Where
- Taiwan
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Global Developmental Delay
Design and Implementation of a Carer Aromatherapy Training (CAT) Program for Children With Global Developmental Delay in Hong Kong: A Mixed Qualitative Study Using the COM-B Framework
This project aims to design and implement a Carer Aromatherapy Training (CAT) program, guided by the Capability, Opportunity, Motivation and Behaviour (COM-B) model, to empower carers with safe and effective aromatherapy…
- Trial name
- CAT programme (NCT07800689)
- Testing
- Carer Aromatherapy Training (CAT) program and home massage with massage oil with the mixture of Petitgrain Mandarin (Citrus reticulate) essential oil and fractionated coconut oil
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Cerebral Palsy, Developmental Delay
SmarToyGym: Smart Detection of Atypical Toy-oriented Actions in At-risk Infants
The study aims to develop a SmarToyGym where sensitized, wireless toys are strategically hung and placed within reach of infants to elicit toy-oriented body and arm/hand movements.
- Conditions
- Cerebral Palsy, Developmental Delay, Stroke, Fine Motor Delay
- Trial name
- NCT02813889
- Testing
- SmarToyGym
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
MNRI, Development Delay
Effects of MNRI Therapy on Fine Motor Skills in Children With Developmental Delays.
Developmental delay refers to a child's failure to achieve age-appropriate developmental milestones and may affect multiple developmental domains.
- Trial name
- NCT07764926
- Testing
- MNRI, Conventional Physiotherapy without MNRI
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Developmental Delay Disorder, Intellectual Disability
Clinical Trial of the Dual Vector Base Editor for the Treatment of the CHD3-R1025W Mutation
To evaluate the safety, tolerability and preliminary efficacy study of a single intrathecal injection of the dual vector AAV-CHD3-R1025W base editor for the treatment of developmental disorders caused by the R1025W mutation in…
- Conditions
- Developmental Delay Disorder, Intellectual Disability, Rare Diseases
- Trial name
- NCT06860672
- Testing
- Dual vector DNA base editor
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Yongguo Yu
Mental Retardation, Developmental Delay
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo)
Development of a new MS-based biomarker for the ear-ly and sensitive diagnosis of Sanfilippo Disease Type A-B-C-D from blood (plasma)
- Trial name
- BioSanfilippo (NCT02298686)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Encephalopathy, Developmental Delay and Behavioral Changes
RCT for Intermittent Versus Continuous Propofol Sedation for Pediatric Brain and Spine MRI Studies
RCT for Intermittent versus Continuous Propofol Sedation for Pediatric Brain and Spine MRI Studies
- Conditions
- Encephalopathy, Developmental Delay and Behavioral Changes, Cord Tumor Compression or Instability, Cord Tethering or Malformation
- Trial name
- NCT00515359
- Testing
- Intermittent Propofol Sedation, Continuous Propofol Sedation
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Corewell Health West
Genetic Disorder, Metabolic Disease
Studies of Children With Metabolic and Other Genetic Disorders
This study will provide medical evaluations for patients with known or suspected metabolic and genetic disorders. It will allow NICHD investigators and trainees experience in diagnosing, managing, and treating patients with…
- Trial name
- NCT00025870
- Where
- United States
- Volunteers
- 1,090 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cerebral Palsy, Genetic Disease
Genetic Etiology in Patients With Cerebral Palsy
Cerebral palsy (CP) is a permanent disorder of movement or posture due to non-progressive impairments of the developing brain. Current estimates indicate that as many as 30% of CP cases may be genetic in nature.
- Conditions
- Cerebral Palsy, Genetic Disease, Developmental Delay, Metabolism, Inborn Errors
- Trial name
- GenCP (NCT05123768)
- Testing
- NGS
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Cerebral Palsy, Spastic Quadriplegic, Communication Disorder, Childhood
Relationship Between Communication and Gross Motor Function in Quadriparetic Cerebral Palsy
Communication problems are frequently encountered in quadriparetic cerebral palsy. Additionally, motor impairments often accompany this condition.
- Conditions
- Cerebral Palsy, Spastic Quadriplegic, Communication Disorder, Childhood, Gross Motor Delay
- Trial name
- NCT06591689
- Testing
- Evaluation of Cases with Quadriparetic Cerebral Palsy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Acıbadem Atunizade Hospital