Clinical trials: Neurodevelopmental Disability
Developmental Delay
Early Intervention in Children at Risk of Developmental Delay
Although it is stated in the literature that development should be considered as a whole and sensory, cognitive and motor outcomes are interrelated, it is seen that interventions for sensory and cognitive skills are not included…
- Trial name
- NCT06052410
- Testing
- Early Intervention, Home Programme
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Rett Syndrome
A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome
This study will evaluate the efficacy and safety profiles of the investigational gene therapy, NGN-401, in females with typical Rett syndrome.
- Trial name
- NCT05898620
- Testing
- NGN-401
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 33 people
- Sponsor
- Neurogene Inc.
Fragile X Syndrome, Intellectual Disability
Effects of Social Gaze Training on Brain and Behavior in Fragile X Syndrome
The purpose of the study is to evaluate a 2-3 day treatment probe targeted to improving social gaze behavior in children with fragile X syndrome (FXS).
- Trial name
- NCT02616796
- Testing
- Social gaze training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Stanford University
Preterm Birth, Low Birthweight Neonate
Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial
The ground-breaking Prevention of Prematurity and Xylitol (PPaX) cluster randomized controlled clinical trial was conducted in Lilongwe, Malawi and enrolled approximately 10,069 pregnant individuals seeking to evaluate the impact…
- Conditions
- Preterm Birth, Low Birthweight Neonate, Periodontitis, Gingivitis
- Trial name
- XaPPP (NCT07424846)
- Testing
- Xylitol Chewing gum, Sorbitol chewing gum
- Where
- Malawi
- Volunteers
- 6,000 people
- Sponsor
- University of Washington
Intellectual Disability, Developmental Disability
Research Engagement With People With Intellectual and Developmental Disabilities
The objectives of this project are to to build sustainable regional communities of Intellectual or Developmental Disabilities (IDD) stakeholders to provide ongoing input to research priorities, methodological processes, and…
- Conditions
- Intellectual Disability, Developmental Disability, Chronic Conditions, Multiple
- Trial name
- PCORI (NCT04182347)
- Testing
- Health Research ToolKit Development
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Intellectual Disability
Dialectical Behaviour Group Therapy for Adults With Intellectual Disabilities
To determine the feasibility and effectiveness of a RCT of an adapted DBT group delivered to individuals with ID and emotional dysregulation.
- Trial name
- NCT02919826
- Testing
- Adapted Dialectical Behaviour Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Dr. Jessica Jones
Microcephaly, Mental Retardation
Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
This prospective cohort study will determine the natural history of fetal exposure to Zika virus (ZIKV) and its effects on the fetus and newborn with emphasis on neurodevelopment outcome.
- Trial name
- ZENI (NCT02943304)
- Testing
- Symptomatic pregnant women with positive RT-PCR ZIKV in serum or urine, or a positive serologic test specific for ZIKV
- Where
- Colombia
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Universidad Industrial de Santander
Reading Disability
Executive Function in Early Childhood
Despite the fact that a substantial number of school age children struggle with both reading and math acquisition, the brain mechanisms of the overlapping aspects of reading and math skills, thought in part to be linked via…
- Trial name
- NCT03713125
- Testing
- Reading Tutoring
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Dyslexia
Maturation of Auditory Processing in Children With Dyslexia Compared to Average-reading Children
The hypothesis of central auditory processing disorders has been advanced to explain the anomalies of the grapheme/phoneme combination in some dyslexia.
- Trial name
- ASTRAUCOLE (NCT02345876)
- Testing
- no intervention
- Where
- 3 sites in France
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Developmental Disability
Benefits of Coding Training on Young Adults With Developmental Disabilities
The purpose of the present study is to develop and evaluate the Technology Early Career Preparation Intervention (TECH-Prep) program with African American high school students with developmental disabilities.
- Trial name
- NCT05132491
- Testing
- TECH-Prep Intervention
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Epilepsy, Mental Retardation
Use of Sustained Release Antiepileptic Medication (Depakote® ER) for Pediatric Epilepsy in a Mental Retardation/Developmental Disorder Population
This study is being done to see if children with learning problems can learn how to swallow pills without chewing them. The reason this is important is that if a person has seizures, medications must be taken every day.
- Conditions
- Epilepsy, Mental Retardation, Developmental Disabilities
- Trial name
- NCT00207935
- Testing
- Swallow instruction
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
Williams Syndrome, Anxiety
Cognitive and Behavioral Therapy of Anxiety in Williams Syndrome
Patients with Williams-Beuren syndrome are eight times more likely to suffer from anxiety compared to the general population. Few therapeutic solutions are proposed to these patients.
- Trial name
- WILL-COPE (NCT03827525)
- Testing
- Cognitive and Behavioral Therapy
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Dyslexia, Adolescent
Usefulness of an Assistive Technology Training Program for Adolscents With Dyslexia
Specific Written Language Disorders (SWLD) are severe and lasting impairments in the development of written language that affect approximately 10% of the school-age population.Concerned patients don't have any intellectual…
- Trial name
- FormONC (NCT05636813)
- Testing
- Training
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Caen
Speech Articulation Disorder, Developmental Articulation Disorder
Randomized Clinical Trial of Phonological Interventions
Recent research reveals genetic and symptomatic overlap among children with speech sound disorders (i.e., those who (misarticulate more sounds than would be expected for their age) and children with dyslexia (i.e., those who…
- Conditions
- Speech Articulation Disorder, Developmental Articulation Disorder, Phonological Impairment, Dyslexia
- Trial name
- ECRIP (NCT00818428)
- Testing
- Speech Production Intervention, Speech Perception Intervention, Articulation Parent Group
- Where
- 2 sites in Canada
- Volunteers
- 96 people
- Sponsor
- McGill University
Intellectual Disability
Motor and Cognitive Dual-task Gait Training Effect Functional Outcome in Intellectual Disability
To find out the comparative effects of motor and cognitive dual gait training on improving the balance control and mobility skills among intellectual disable patients.
- Trial name
- NCT05334498
- Testing
- Motor dual-task gait training, Cognitive dual-task gait training
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Intellectual Disabilities
Effects of Two Intervention Programs on Physical Fitness and Quality of Life Among People With Intellectual Disabilities
Intellectual Disability (ID) is characterized by limitations in cognitive functioning and adaptive behavior, often leading to a sedentary lifestyle and lower quality of life.
- Trial name
- NCT07576933
- Testing
- Traditional physical conditioning, Sport-based individual skills
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Developmental Language Disorders, Developmental Articulation Disorder
Smart Computing Models, Sensors, and Early Diagnostic Speech and Language Deficiencies Indicators in Child Communication
This clinical trial aims to justify a protocol for designing and developing an automated decision-making system to support and enhance screening and early detection procedures for developmental speech/language difficulties in…
- Conditions
- Developmental Language Disorders, Developmental Articulation Disorder, Speech Disorder, Neurodevelopmental Disorder (Diagnosis)
- Trial name
- SmartSpeech (NCT06633874)
- Testing
- TD Playing the Serious Game APSOU, Non-TD Playing Serious Game
- Where
- Greece
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University of Ioannina
Seizures, Development Delay
Review of Diagnostic Yield of MRI Brain Results in Children Under Age 3 Years
The investigators aim to identify the frequency with which an elective brain MRI yields and etiologic diagnosis to explain its indication.
- Conditions
- Seizures, Development Delay, Anesthetic Neurotoxicity
- Trial name
- NCT03561168
- Testing
- Change in plan of care based on MRI results
- Where
- United States
- Volunteers
- 561 people
- Sponsor
- Baylor College of Medicine
Learning Disabilities
Action Medical Research
Learning disability affects 3% of the population. Severe types of learning disability are more likely to have an underlying genetic cause but diagnosis is difficult because many different genetic abnormalities may be involved.
- Trial name
- NCT02227381
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- Manchester University NHS Foundation Trust
Neurodevelopmental Disorders, Autism Spectrum Disorder (ASD)
Single Session Support for Parents of Children With Neurodevelopmental Disabilities Struggling With Anxious Avoidance
This study will inform the development of a brief online program to help parents better understand and respond to anxiety-related behaviors in children with neurodevelopmental disorders (NDDs) such as autism spectrum disorder…
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), Intellectual Disability
- Trial name
- EMPOWER-ND (NCT07898592)
- Testing
- EMPOWER-ND
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston University Charles River Campus
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