Clinical trials: Neurodevelopmental Disability
Intellectual Disabilities
Picture-based Computerised Assessment and Training of Cognitive Behaviour Therapy Skills
The proposed research aims to investigate whether people with intellectual disabilities are able to understand and apply the theoretical principles of cognitive behaviour therapy (CBT) regarding the interaction between events…
- Trial name
- NCT01652963
- Testing
- Reed and Clements Training Task
- Where
- 3 sites in United Kingdom
- Volunteers
- 132 people
- Sponsor
- University of East Anglia
Asperger's Syndrome, Dyslexia
My Scrivener® - Measuring Effectiveness and Dose Response in Children
This study will assess whether a computer haptic peripheral device programmed to provide repetitive motion training is as effective as the same repetitive motion training provided by a human being.
- Conditions
- Asperger's Syndrome, Dyslexia, Cerebral Palsy, Attention Deficit Disorder
- Trial name
- NCT00919906
- Testing
- My Scrivener(R)
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Obslap Research LLC
Learning Disability
Investigating the Clinical and Cost Effectiveness of Lycra Splinting
People with learning disabilities (LDs) experience high levels of health problems, including cerebral palsy, other problems associated with posture, movement and function, and injury (falls are the commonest cause of injury in…
- Trial name
- NCT02345512
- Testing
- Lycra Splinting Garment
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Glasgow Caledonian University
Aggression, Intellectual Disability
Reducing Aggression Among People With an Intellectual Disability
The study is an randomised controlled trial (RCT) to test whether supplementation of vitamins, minerals and n-3 fatty acids may reduce aggressive behavior in people with intellectual disabilities.
- Trial name
- PSYVB (NCT03212092)
- Testing
- Multivitamin, mineral & n-3 FA
- Where
- 7 sites in Netherlands
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Balanced Chromosomal Translocation
Breakpoint Analysis of de Novo Apparently Balanced Chromosomal Translocations
For every child with developmental delay, the investigators do a constitutional karyotype. This karyotype can reveal an apparently balanced chromosomal rearrangement (no visible loss or gain of genetic material), such as a…
- Trial name
- NCT01826708
- Testing
- Identification of breakpoints
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Treatment Satisfaction, Knowledge Acquisition Disability Nos
Psychoeducation for Adults With Autism and Their Significant Others/Family Members
Prisma is a four-session psychoeducational intervention administered in groups for individuals with ASD together with their family members and significant others.
- Conditions
- Treatment Satisfaction, Knowledge Acquisition Disability Nos, Anxiety, Depression
- Trial name
- Prisma (NCT04460976)
- Testing
- Psychoeducation for Adults With Autism and Their Significant Others/Family members (Prisma), Treatment as usual/standard care
- Where
- Sweden
- Volunteers
- 718 people
- Sponsor
- Karolinska Institutet
Child Development Disorders, Pregnancy
The Effect of Thyroid Hormone Levels in Pregnant Women on the Intelligence Quotient (IQ) of Their Children
This study is designed to test the hypothesis that the level of the thyroid hormone thyroxine (specifically, free thyroxine, FT4) circulating in the blood of pregnant women is the key thyroid-related factor to influence early…
- Conditions
- Child Development Disorders, Pregnancy, Subclinical Hypothyroidism
- Trial name
- NCT00147433
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Reading Disorder
Gene x Environment Interplay in Developmental Dyslexia Treatment: A Round-trip Translation Between Humans and Animal
Developmental dyslexia affects 7% of school-age children (Male:Female ratio of 1.5:1) and incurs disadvantages in education and occupation.
- Trial name
- Gedys (NCT06186882)
- Testing
- Action Video-Game
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
ADHD, Dyslexia
A Strength-Based Intervention to Improve Job Interview Skills in Neurodiverse Young Adults
the investigators are looking to evaluate the effectiveness of a strength-based program in improving job interview skills in neurodiverse young adults.
- Conditions
- ADHD, Dyslexia, Learning Disabilities
- Trial name
- NCT06479850
- Testing
- KF-STRIDE®
- Volunteers
- 50 people
- Sponsor
- Kessler Foundation
Development Delay, Development, Child
The Opening Doors to Early Intervention Study
Poor urban minority children often experience delays in their early development leading to health disparities. Publicly funded early intervention services are available to improve child development among these children in…
- Trial name
- ODEI (NCT03625115)
- Testing
- Family Navigator (FN)
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Children's Hospital of Philadelphia
Cerebral Palsy, Developmental Delay
Efficacy of the START-Play Program for Infants With Neuromotor Disorders
The purpose of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to improve development and…
- Conditions
- Cerebral Palsy, Developmental Delay, Infant Development
- Trial name
- START-Play (NCT02593825)
- Testing
- START-Play intervention, Business as usual
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Duquesne University
Child Development Disorders, Pervasive
Assessing Suicide Risk in Adolescents With Developmental Delays
Background: Currently, there is no standard method to study suicide risk in youth with developmental delays or intellectual disabilities (DD/ID).
- Trial name
- NCT01517126
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
Developmental Delay
Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder
Background: People show changes in brain activity when they watch other people do actions. This may be part of early social and communication skills.
- Trial name
- NCT03307317
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Dyslexia, Developmental
Developmental Dyslexia and Remediation Methods
At least, three theoretical frameworks are currently involved in therapeutic research in developmental dyslexia. Each theoretical framework relies on the type of underlying cognitive processes that is viewed as impaired: 1°)…
- Trial name
- DDMR (NCT04028310)
- Testing
- Phonological, Visual-attention
- Where
- France
- Volunteers
- 145 people
- Sponsor
- Fondation Lenval
Feasibility
Supporting Family Carers' Mental Health
Brief Summary: Background: Feasibility and acceptability of the Carers-ID intervention to improve mental health outcomes in family carers of people with intellectual disabilities. Objective: 1.
- Trial name
- NCT05737823
- Testing
- Carers-ID online support programme, Carers-ID online support programme - Wait-list control
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Developmental Disability, Intellectual Disability
Effect of Sensory Adapted Dental Environment on Dental Anxiety of Children With Intellectual and Developmental Disabilities
Children with intellectual/developmental disabilities (ID/DD) will experience less dental anxiety and cooperate better in a Sensory Adapted Dental Environment (modified visual, sensory, and somatosensory stimuli in a regular…
- Conditions
- Developmental Disability, Intellectual Disability, Dental Anxiety
- Trial name
- NCT03218462
- Testing
- Sensory Adapted Dental Environment (SADE)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Virginia Commonwealth University
Developmental Disability, Early Intervention (Education)
Participation and Environment Measure-Plus (PEM-Plus) Care Planning Intervention
The goal of the proposed research is to achieve a major advance in promoting effective and efficient delivery of pediatric rehabilitation services for young children with developmental disabilities and delays.
- Trial name
- PEM-Plus (NCT03820011)
- Testing
- PEM+
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mary A Khetani
Dyslexia, Developmental
Tackling Two of the Most Important Unresolved Tasks in Reading Intervention
An important question in education is how to help young children who struggle to learn to read despite being well-taught in their regular classrooms.
- Trial name
- NCT06403007
- Testing
- Phonics plus morphology, Phonics plus set-for-variability
- Where
- 2 sites in Canada
- Volunteers
- 964 people
- Sponsor
- York University
Intellectual Disabilities (F70-F79)
Virtual Reality for Dental Anxiety in Children With Mild Intellectual Disability
Virtual reality (VR) is a promising non-pharmacological approach to reduce dental anxiety in children with neurodevelopmental disorders.
- Trial name
- VR-MID (NCT07249359)
- Testing
- Virtual Reality Distraction - immersive VR software delivered through Meta Quest 3® headset during dental procedure, Control: Monitor-Based Distraction
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Oasi Research Institute-IRCCS
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