Clinical trials: Neurodevelopmental Disability
Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Expanded Game Squad for Neurodiverse Youth
The proposed study will pilot the use of an adapted Game Squad intervention aimed at improving physical activity and other important health behaviors (nutrition, sleep hygiene, screen time habits) for children and adolescents…
- Conditions
- Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Health Behavior, Developmental Disorder
- Trial name
- NDGameSquad (NCT03665415)
- Testing
- NDGameSquad
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Merrimack College
Dyslexia, Developmental
Neurofunctional Correlates of the Behavioral Modifications Associated With Tachidino in Children With Developmental Dyslexia
Developmental dyslexia (DD) is the most common learning disorder. Multiple cognitive and sensory domains contribute to the etiology of DD and develop before reading acquisition.
- Trial name
- TACHIDINO (NCT05373576)
- Testing
- TACHIDINO
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Mental Retardation, Stereotyped Behavior
Repetitive Behavior Disorders in People With Severe Mental Retardation
Repetitive behavior disorders are prevalent among people with severe mental retardation. These disorders can interfere significantly with an individual's daily functions.
- Conditions
- Mental Retardation, Stereotyped Behavior, Self-Injurious Behavior, Compulsive Behavior
- Trial name
- NCT00491478
- Testing
- sertraline
- Where
- 2 sites in United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Intellectual Disability, Weight Loss
POWERSforID: A Telehealth Weight Management System for Adults With Intellectual Disability
POWERSforID is a 24 week randomized control trial designed to assess the feasibility of a telehealth and coaching intervention for improving health outcomes of adults with intellectual disability.
- Conditions
- Intellectual Disability, Weight Loss, Motivational Interviewing, Telehealth
- Trial name
- POWERSforID (NCT03139760)
- Testing
- POWERSforID
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Mental Retardation, Spasticity
Prevalence of Spasticity in Adults With Mental Retardation Living in the Community
This survey aims to investigate the prevalence of spasticity among adults who live in community settings in Davidson County, Tennessee.
- Trial name
- NCT00282191
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University
Fetofetal Transfusion
The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion Syndrome
Twins who share a placenta but have two separate sacs of amniotic fluid (monochorionic-diamniotic) are at risk of developing twin-to-twin transfusion syndrome (TTTS).
- Trial name
- NCT02249624
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Catherine Cibulskis, MD
Autistic Disorder
Associative Memory in Adults With an Autism Spectrum Disorder
The objective of this multidisciplinary project is to explore the deficit of associative memory in ASD (Autistic Spectrum Disorder) that could result from abnormal brain connectivity.
- Trial name
- MEM-T2A (NCT02279680)
- Testing
- Electroencephalography, Neuropsychological assesments
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Rett Syndrome
Safety and Preliminary Efficacy of TSHA-102 Gene Therapy in Pediatric Females Aged >2 to <4 Years With Rett Syndrome
The primary objectives of this study are to evaluate the safety, tolerability and preliminary efficacy of a single intrathecal (IT) dose of TSHA-102 in pediatric females with typical Rett syndrome.
- Trial name
- ASPIRE (NCT07480564)
- Testing
- TSHA-102
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Taysha Gene Therapies, Inc.
Fetal Alcohol Spectrum Disorders, Behavior Problem
Psychoeducation of Parents to Children With FASD
By longitudinal, prospective research in children and adolescents with Fetal Alcohol Spectrum Disorders (FASD) and their parents to explore the beneficial effects of participating in a standardized intervention program in order…
- Conditions
- Fetal Alcohol Spectrum Disorders, Behavior Problem, Adaptive Behavior, Learning Disorders
- Trial name
- NorFASDPEdu (NCT05686473)
- Testing
- Program of psychoeducation of parents and professionals
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Sorlandet Hospital HF
Angelman Syndrome
Characterization of Angelman Syndrome
Angelman Syndrome (AS) is a developmental disorder that is caused by a deficiency of a maternally transmitted gene. It is inherited at birth, and affects movement, speech, and social demeanor.
- Trial name
- NCT00296764
- Where
- 6 sites in United States
- Volunteers
- 302 people
- Sponsor
- Boston Children's Hospital
Abnormalities, Failure to Thrive
Evaluation of Patients With Unresolved Chromosome Abnormalities
The purpose of this research is to study a new way to test for chromosome abnormalities. Chromosomes are strands of DNA (the genetic material in the cell nucleus) that are made up of genes-the units of heredity.
- Conditions
- Abnormalities, Failure to Thrive, Mental Retardation, Microcephaly
- Trial name
- NCT00001639
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Intellectual Disabilities (F70-F79), Autism Spectrum Disorder
Emotion Processing and Regulation in People With Intellectual Disability
BACKGROUND Intellectual disability (ID) is neurodevelopmental disorder with social impairments, in areas such as interpersonal communication skills and emotion regulation.
- Trial name
- EPRID (NCT06894264)
- Testing
- Emotion regulation
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
PTEN Gene Mutation, PTEN Hamartoma Tumor Syndrome
RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome
Phosphatase and TENsin homolog (PTEN) gene germline mutations are associated with a spectrum of clinical manifestations characterized by neurocognitive deficits, intellectual disability, autism symptomatology, skin lesions…
- Trial name
- NCT02991807
- Testing
- RAD001
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Boston Children's Hospital
Neurodevelopmental Disorders
Omic Approaches to Neurodevelopmental Disabilities
to bridge the gap between the molecular structure of CNV and the effect on the phenotype, considering NDDs as complex diseases, as they are a consequence of the imbalance in several dosage-sensitive genes, we might try to…
- Trial name
- NCT06337396
- Testing
- WGS and transcriptome analysis
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS Eugenio Medea
Intellectual Disability
Future Planning and Well-Being for Individuals With Intellectual Disabilities and Family Caregivers
This study will compare the effectiveness of a web-based long-term care planning tool (Map Our Life) partnered with traditional case management services to traditional case management services partnered with an attention-control…
- Trial name
- NCT06065527
- Testing
- Map Our Life, Attention Control
- Where
- United States
- Volunteers
- 1,050 people
- Sponsor
- Northwell Health
Very Preterm Birth
EPIPAGE2 Cohort Study Follow up at Five and a Half Years
Epipage 2 (epidemiologic study on small-for-gestational-age children) is a nationwide study implemented to improve our knowledge of the outcome of preterm children in France.
- Trial name
- EPIPAGE2 (NCT03078439)
- Testing
- Medical and neuropsychological assessments
- Where
- 98 sites in France, French Guiana and 2 more
- Volunteers
- 3,404 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intellectual Disabilities
Nature and Frequency of Genetic Abnormalities and Associated Phenotypes in a Cohort of Adults With Intellectual Disability
Intellectual disability (ID) is characterized by having an intelligence quotient (IQ) below 70 and substantial limitations in adaptive functioning across different domains, with the condition manifesting before the age of 18.
- Trial name
- HiNDIA (NCT06630195)
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tooth Decay, Intellectual Disability
Probiotics in Special Needs Patients at High Risk for Tooth Decay: a Randomized Controlled Trial.
The goal of this randomized clinical trial is to test the effect orally administration of Probiotics based on Lactobacillus rhamnosus LR04 and Lactobacillus plantarum LP14 as adjuvant in caries prevention in subjects who can not…
- Conditions
- Tooth Decay, Intellectual Disability, Caries,Dental
- Trial name
- NCT06063239
- Testing
- Test Group, Positive Control, Negative Control
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- G. d'Annunzio University
Cognitive Disorder, Metabolic Disease
Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency
Background: Creatine transporter deficiency (CTD) is a genetic disorder that mainly affects the brain in males. CTD causes intellectual disability that can be mild to severe.
- Conditions
- Cognitive Disorder, Metabolic Disease, Autism Spectrum Disorder
- Trial name
- NCT05600946
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Intellectual Disability
Second Molecular Event Identification by Exome Sequencing for Intellectually Disabled Patients Carrying 16p13.11 CNVs
16p13.11 copy number variations are considered as predisposition factors for neurodevelopmental disorders but can be inherited from normal parents.
- Trial name
- SEESIC (NCT03644797)
- Testing
- Exome sequencing
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Hospices Civils de Lyon
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