Clinical trials: Neurogenic Bladder, open to volunteers
Neurogenic Dysfunction of the Urinary Bladder, Multiple Sclerosis
Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction
A multi-center double-blinded placebo-controlled randomized clinical trial. The patients will be randomized into two groups. To investigate the efficacy of SNM to improve the key bladder diary variables compared to placebo (i.e.
- Conditions
- Neurogenic Dysfunction of the Urinary Bladder, Multiple Sclerosis, Sacral Neuromodulation, Bowel Dysfunction
- Trial name
- NCT05380856
- Testing
- Turning ON the neuromodulator, Turning OFF the neuromodulator
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Overactive Bladder
Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder
OnabotulinumtoxinA is an effective treatment for both idiopathic and neurogenic overactive bladder and was FDA approved for this indication in 2013.
- Trial name
- NCT04020510
- Testing
- onaBoNT-A
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Neurogenic Bladder, Multiple Sclerosis
Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS
Neurogenic overactive bladder (NOAB), characterized by urinary frequency, urgency or urgency incontinence symptoms occurring during the storage phase of the bladder, is the most common urinary complaint in multiple sclerosis…
- Conditions
- Neurogenic Bladder, Multiple Sclerosis, Overactive Bladder
- Trial name
- MSBLADDER (NCT06072703)
- Testing
- Magstim Rapid2 System
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The Methodist Hospital Research Institute
Neurogenic Bladder
Device for Bladder Control for Men With SCI
Urinary incontinence, bladder frequency, and bladder urgency are significant medical problems for people with overactive bladder (OAB) or neurogenic bladder overactivity (NDO).
- Trial name
- NCT07668063
- Testing
- Noninvasive electrical stimulation device to improve bladder control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Neurogenic Bladder
Bilateral Comparison of Unilateral Sacral Neuromodulation Test Stimulation in the Treatment of Neurogenic Bladder
Neurogenic bladder (NB) is a general term for a series of lower urinary tract symptoms and complications caused by bladder and/or urethral dysfunction caused by nervous system lesions.
- Trial name
- NCT07505940
- Testing
- bilateral sacral nerve stimulation (BNS)
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Qilu Hospital of Shandong University
Overactive Bladder, Overactive Bladder Syndrome
Optimal Intravesical Lidocaine Volume for Pain Relief During Office Intra-detrusor Onabotulinum Toxin a Injections
The purpose of our study is to evaluate the efficacy and safety of different volumes of bladder-numbing medication for pain relief at the time of office bladder Botox injections.
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Urinary Urgency, Urinary Frequency
- Trial name
- NCT06695585
- Testing
- Lidocaine 2% without vessel constrictor
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Louisville
Spinal Cord Injuries, Neurogenic Bladder
Intravesical LGG VS Saline Bladder Wash RCT
This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI).
- Trial name
- NCT05230511
- Testing
- Lactobacillus RhamnosusGG, Saline bladder wash
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Medstar Health Research Institute
Asymptomatic Bacteriuria in Subjects Not Requiring Assisted Bladder Emptying, Asymptomatic Bacteriuria in Subjects Relying on Some Type of Catheter
Effects of Microbiological and Immunological Factors on the Lower Urinary Tract
Millions of patients of all ages suffer worldwide from diverse urinary pathologies, such as lower urinary tract (LUT) dysfunction, bladder pain syndrome, urinary tract infections (UTIs), or bladder cancer.
- Conditions
- Asymptomatic Bacteriuria in Subjects Not Requiring Assisted Bladder Emptying, Asymptomatic Bacteriuria in Subjects Relying on Some Type of Catheter, Recurrent Non-catheter Associated UTIs, Acute Catheter-associated UTI (CAUTI)
- Trial name
- MiLUT (NCT07494864)
- Where
- Switzerland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injuries
Early BOTOX After Spinal Cord Injury
The investigators would like to improve our understanding of how early intervention with the use of bladder chemodenervation can preserve bladder function in those with a new SCI.
- Trial name
- NCT06793683
- Testing
- Bladder chemodenervation (Botox)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Neurogenic Bladder Due to Spinal Dysraphism
EVALUATION OF THE SAFETY AND EFFICACY OF ADJUSTABLE CONTINENT THERAPY IN CHILDREN WITH SPINAL DYSRAPHISM.
Urinary continence is still a difficult goal to achieve in neurogenic bladder patients. Conservative treatment of neurogenic urinary incontinence using clean intermittent catheterization in conjunction with pharmacological…
- Trial name
- BPUA (NCT03351634)
- Testing
- Implantation of ACT balloon, Uromedica (Irvine, CA, USA) periurethrally at the bladder neck
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Postoperative Urinary Retention (POUR)
Efficacy of Acupuncture for Postoperative Urinary Retention Following Radical Hysterectomy for Cervical Cancer
The goal of this clinical trial is to learn if acupuncture works to treat postoperative urinary retention in patients who have undergone radical hysterectomy for cervical cancer.
- Trial name
- APOUR (NCT07711977)
- Testing
- Acupuncture
- Volunteers
- 324 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Spinal Cord Injury (SCI), Neurogenic Bladder (NB)
Home Neuromodulation for Neurogenic Bladder Management in Spinal Cord Injury
The purpose of this study is to determine the safety and efficacy of Injectrode Tibial Nerve Stimulation for bladder function in people with spinal cord injury.
- Trial name
- NCT07264868
- Testing
- iTNS
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injury, Detrusor Overacitivity
Effects of Sacral and Tibial Stimulation on Bladder Function in Subacute Suprasacral Spinal Cord Injury
Suprasacral spinal cord injury (SCI) frequently leads to neurogenic detrusor overactivity (NDO), resulting in elevated bladder storage pressures, urinary incontinence, and an increased risk of upper urinary tract damage.
- Trial name
- NCT07343583
- Testing
- Transcutaneous Tibial Nerve Stimulation, Transcutaneous Sacral Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Overactive Bladder Syndrome, Neuropathic Bladder
Oxybutynin for Post-surgical Bladder Pain and Urgency
Bladder pain and urgency are common after bladder surgery. The objective is to determine if transdermal administration is superior to oral administration in alleviating pain and urgency.
- Trial name
- NCT03952299
- Testing
- Oxybutynin Transdermal Patch, Oral Oxybutynin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Overactive Bladder
Efficacy of Gabapentin Combined With Solifenacin for Non-neurogenic Overactive Bladder in Women
The goal of the study is to compare the efficacy, safety and tolerability of solifenacin plus gabapentin versus solifenacin monotherapy for the treatment of women who are suffering from non-neurogenic ОАВ.
- Trial name
- NCT07429734
- Testing
- solifenacin combined with gabapentin, solifenacin monotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Spinal Cord Injuries, Neurogenic Bladder Dysfunction
Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury
Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the…
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder Dysfunction, Degenerative Cervical Spinal Stenosis
- Trial name
- NCT05681936
- Where
- Switzerland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injuries (SCI), Neurogenic Bladder
Intravesical Lactobacillus Crispatus: Clinical Safety and Microbiome Evaluation
The goal of this clinical trial is to determine whether Lactobacillus crispatus strains isolated from the lower urinary tracts of adult women can be used as an antibiotic-sparing treatment for urinary symptoms and urinary tract…
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Bladder, Urinary Tract Infection (Diagnosis)
- Trial name
- NCT07308808
- Testing
- Lactobacillus Crispatus, Saline bladder wash
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medstar Health Research Institute
Stroke, Neurogenic Overactive Bladder
Transcranial Direct Current Stimulation for Neurogenic Overactive Bladder Symptoms Among People With Stroke
Neurogenic overactive bladder (nOAB) is a common and distressing sequela following stroke, significantly impairing quality of life and imposing a substantial financial burden.
- Trial name
- NCT07768137
- Testing
- Active transcranial direct current stimulation (tDCS), Pelvic floor muscle training (PFMT)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Urinary Bladder, Neurogenic, Urodynamics
Measurement of Bladder Pressure With a Novel External Device, Comparison to Urodynamics Testing
The investigators have developed a novel pressure monitoring device that hooks to standard urinary catheters. The investigators will be testing how the pressure measurements recorded with this device compare to the gold standard…
- Trial name
- NCT03456089
- Testing
- Urodynamics Testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Christopher Cooper
Urinary Retention, Neurogenic Bladder
Consumer Evaluation of an Investigational Intermittent Catheter
This clinical study is designed to evaluate the initial safety and performance of an investigational intermittent urinary catheter in people who use intermittent catheterization.
- Trial name
- NCT07714694
- Testing
- An intermittent urethral urinary catheter with a tip, tube and drainage eyelets
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hollister Incorporated