Clinical trials: Neuroimaging
Schizophrenia, Schizoaffective Disorder
Database Registry for Neural Network Biomarkers in Psychosis
Several observations have been made with magnetic resonance imaging (MRI) that characterize brain connections and brain function in individuals with schizophrenia and other mental disorders.
- Trial name
- Imaging (NCT01409109)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Sturge-Weber Syndrome
Longitudinal Neuroimaging in Sturge-Weber Syndrome
In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging approach, that can create…
- Trial name
- NCT04517565
- Testing
- Brain magnetic resonance imaging, Neuro-psychology testing
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Perceptual Disorders, Stroke
Neurobiomarker for Prism Adaptation Treatment Response
Preliminary data will be collected about which individuals with spatial neglect from right hemisphere stroke (aiming vs perceptual neglect) improve with Prism Adaptation Training and if there is a particular pattern of damage in…
- Conditions
- Perceptual Disorders, Stroke, Biomarker
- Trial name
- NCT04966000
- Testing
- Prism Adaptation Therapy
- Where
- United States
- Sponsor
- University of Utah
Parkinson's Disease (PD), GBA1 Parkinson Disease
Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging
The project aims to investigate how abnormal accumulation of alpha synuclein and its interaction with tau influence brain function across the Parkinson's disease (PD) spectrum, with particular focus on individuals carrying GBA1…
- Conditions
- Parkinson's Disease (PD), GBA1 Parkinson Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- SYNchronPD (NCT07474779)
- Testing
- brain imaging, blood draw, Skin biopsy
- Where
- 2 sites in Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Stroke
Imaging the Effects of Bihemispheric Transcranial Stimulation and Motor Training After Stroke.
Functional and structural magnetic resonance imaging (MRI) will be used to investigate neural correlates of bihemispheric transcranial direct current stimulation (tDCS) associated with upper limb rehabilitation in chronic stroke…
- Trial name
- NCT04195412
- Testing
- tDCS + upper limb rehabilitation
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- D'Or Institute for Research and Education
Anxiety
Fmri-based Neurofeedback With Anxious Adolescents Study
Adolescents are particularly vulnerable to psychological problems, partly because of dramatic changes in the brain, along with changes in social interactions patterns as they move from childhood towards adulthood.
- Trial name
- NF-AA (NCT02463136)
- Testing
- questionnaires, Functional magnetic resonance imaging w neurofeedback
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Obesity
A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation
This study will examine a potential relationship between family history of obesity, that is whether people with at least one parent who had obesity in adulthood compared to people with two parents who did not have obesity in…
- Trial name
- OPBIM (NCT06353464)
- Testing
- Ensure and Water
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Drexel University
the Objective Diagnosis of Depression
A Multicentre Clinical Study
This study intends to conduct a multi-center, large-sample clinical trial, aiming at using multi-channel near-infrared spectroscopy to detect the characteristics of brain Oxy-Hb changes over time during cognitive activation in…
- Trial name
- NCT07062666
- Testing
- SSRIs, fNIRS
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- Zhongda Hospital
Brain Tumor
Evaluation of Intra Axial Brain Masses Based on Magnetic Resonance in Adults
Although the Magnetic resonance imaging with contrast is the gold standard for diagnosis of intra axial brain masses. The conventional Magnetic resonance imaging appearances of intra axial brain masses can be non-specific and…
- Trial name
- NCT03166592
- Testing
- Magnetic resonance imaging with contrast
- Where
- 2 sites in Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Tobacco Dependence, Smoking Cessation
Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence
The addition of tDCS as an adjunct to pharmacotherapy is a novel approach but one that is grounded in a growing evidence-base.The primary objective of this research is to provide preliminary evidence of the effectiveness of tDCS…
- Conditions
- Tobacco Dependence, Smoking Cessation, Tobacco Smoking, Tobacco Use Disorder
- Trial name
- NCT03841292
- Testing
- Varenicline, Active tDCS
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health
Hypogonadism, Malignant Testicular Germ Cell Tumor
7 Tesla MRI Neuroimaging in Testicular Cancer Patients With Hypogonadism and on Androgen Replacement Therapy
This study evaluates 7 Tesla (T) magnetic resonance imaging (MRI) in observing changes in the brain (neuroimaging) in testicular cancer patients who have decreased testosterone (hypogonadism) and are on testosterone (androgen)…
- Trial name
- NCT06191575
- Testing
- 7 Tesla Magnetic Resonance Imaging, Biospecimen Collection, Cognitive Assessment
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Tramatic Brain Injury
The Effects of Chronic Exposure to Low-Level Blasts
Background: Repeated exposure to explosions may lead to changes in the way that people think or feel. Breachers (people trained to use explosives to get into buildings) are exposed to repeated blasts as part of their job.
- Trial name
- NCT01524822
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Major Depressive Disorder (MDD
Amygdala-Targeted Transcranial Temporal Interference Stimulation for Major Depressive Disorder: A Randomized Sham-Controlled Trial of Clinical Efficacy and Neurobiological Mechanisms
This randomized, sham-controlled clinical trial aims to evaluate the efficacy and safety of amygdala-targeted transcranial temporal interference stimulation (tTIS) in adults with major depressive disorder (MDD) and to explore its…
- Trial name
- NCT07829575
- Testing
- Transcranial Temporal Interference Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Anxiety Disorder, Major Depressive Disorder
PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX
Objective: Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that respond to glutamate by activating proteins inside nerve cells that affect cell metabolism, thereby fine-tuning the signals sent between…
- Trial name
- NCT02230592
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Volunteers
Measuring the Latency Connectome in the Central Nervous Systems Using Neuroimaging and Neurophysiological Techniques
Background: Little is known about the time it takes for nerve signals to go from one area of the brain to another. Using advanced methods for brain research, researchers want to look at the time it takes to send messages between…
- Trial name
- NCT03223636
- Testing
- TMS, MRI
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
Imaging Brain Fluids During Breathing
This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.
- Trial name
- NCT05180981
- Testing
- Transcutaneous vagal nerve stimulation, Breathing task
- Where
- 2 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Major Depressive Disorder
Sensory Synchronized Imaging and Neuromodulation
The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans.
- Trial name
- NCT06548113
- Testing
- TMS
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Migraine in Adults
The Effect of Static Magnetic Fields on Neuroinflammation in Migraine
We are conducting this research in individuals with migraines to find out if a daily magnet helmet application could alter migraine-related brain inflammation.
- Trial name
- NCT07584382
- Testing
- Static magnetic helmet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Marco Loggia
Anemia, Sickle Cell
Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease - Pilot Intervention Study
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes and may lead to organ failure.
- Trial name
- NCT00850018
- Testing
- Monthly blood transfusion regimen, Usual care
- Where
- 14 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
CAR T-Cell Therapy
Neuroimaging and Biomarkers of Neurotoxicity After Chimeric Antigen Receptor T-Cell Therapy
The goal of this study is to understand why some people receiving chimeric antigen receptor (CAR) T-cell therapy for cancer experience neurotoxicity.
- Trial name
- NCT07075523
- Testing
- Brain magnetic resonance imaging, neurocognitive assessments, quality of life questionnaire, biomarkers
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, San Diego