Clinical trials: Neurologic Complication
Hydromorphone Use, Acute Postoperative Pain
Methadone and Hydromorphone For Spinal Surgery
Patients undergoing major spinal surgery continue to experience moderate-to-severe pain during the first 2-3 days following the operative procedure.
- Conditions
- Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
- Trial name
- NCT02107339
- Testing
- Methadone, Hydromorphone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Cerebral Palsy, Hip Dysplasia
Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy
Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly.
- Conditions
- Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
- Trial name
- NCT04074265
- Testing
- Ropivacaine injection, normal saline
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of California, Los Angeles
Parkinson's Disease, Neurogenic Bladder
Safety and Efficacy of botulinumA Toxin (BotoxA) for Treatment of Neurogenic Bladder of Parkinson's Disease
The basic nerve deficit of Parkinson's disease (PD) leads to lower urinary tract symptoms of frequency, urgency and urge urinary incontinence. Lower urinary tract symptoms tend to occur at more advanced stages of PD.
- Conditions
- Parkinson's Disease, Neurogenic Bladder, Urinary Incontinence, Clostridium Botulinum Toxin Adverse Reaction
- Trial name
- NCT01421719
- Testing
- Cystoscopic injection of Botox into the urinary bladder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Post-operative Pain, Gynecological Surgery
Acupuncture for Post-Operative Pain Control for Patients Undergoing Gynecological Surgery
This study investigates the role of acupuncture in controlling post-operative pain in patients who have undergone gynecological surgery.
- Conditions
- Post-operative Pain, Gynecological Surgery, Acupuncture
- Trial name
- NCT02855567
- Testing
- Acupuncture needles
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bunionectomy, Pain
A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy
The main objective of this trial is to demonstrate the efficacy and safety of multiple-dose application of oral application of CG5503 IR 75mg compared to placebo and to assess safety and tolerability of CG5503 IR 75mg in subjects…
- Conditions
- Bunionectomy, Pain, Postoperative Pain, Acute Pain
- Trial name
- NCT00609466
- Testing
- CG5503 IR, Morphine
- Where
- 6 sites in United States
- Volunteers
- 291 people
- Sponsor
- Grünenthal GmbH
Postoperative Pain
Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications
Some patients have respiratory depression (decreased breaths per minute) after surgery. Acetaminophen, an FDA approved pain medication, may prevent this problem.
- Trial name
- NCT02156154
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Insomnia, Sleep Fragmentation
Suvorexant and Sleep/Delirium in ICU Patients
Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering in the cardiac intensive care unit…
- Conditions
- Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
- Trial name
- NCT04092894
- Testing
- Suvorexant 20 mg
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Bleeding Disorder, Stroke, Ischemic
XIENCE 28 Global Study
XIENCE 28 Global Study is a prospective, single arm, multi-center, open label, non-randomized trial to further evaluate the safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of…
- Conditions
- Bleeding Disorder, Stroke, Ischemic, Stroke Hemorrhagic, Hematological Disease
- Trial name
- NCT03355742
- Testing
- XIENCE, DAPT
- Where
- 52 sites in Austria, Belgium and 11 more
- Volunteers
- 963 people
- Sponsor
- Abbott Medical Devices
Pain, Postoperative
Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain
This study will evaluate the safety and tolerability based on the incidence of adverse experiences of buprenorphine sublingual spray (0.5 milligrams [mg] three times daily [TID]) compared with standard post-operative narcotic…
- Trial name
- NCT03254459
- Testing
- Buprenorphine Sublingual Spray, Morphine, Oxycodone Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- INSYS Therapeutics Inc
Endometriosis
SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain
The purpose of this study is to evaluate the long-term efficacy and safety of relugolix 40 milligram (mg) once daily co-administered with low-dose estradiol (E2) and norethindrone acetate (NETA) for up to 104 weeks on…
- Trial name
- NCT03654274
- Testing
- Relugolix, Estradiol/norethindrone acetate
- Where
- 169 sites in United States, Argentina and 18 more
- Volunteers
- 802 people
- Sponsor
- Myovant Sciences GmbH
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Delirium
Delirium and EuroSCORE II in Cardiac Surgery
The goal of this observational study is to find out the association between EuroSCORE II of Delirium in patients undergoing cardiac surgery.
- Trial name
- NCT05218720
- Testing
- EuroSCORE II risk score and CAM-ICU (The Confusion Assessment Method for the Intensive Care Unit)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University
Acute Postoperative Pain, Bunionectomy
Evaluate the Efficacy and Safety of ACP-044 for the Treatment of Acute Postoperative Pain Following Bunionectomy
To evaluate the efficacy of ACP-044 compared with placebo in the treatment of acute postoperative pain
- Trial name
- NCT04855240
- Testing
- ACP-044 Dose A, ACP-044 Dose B
- Where
- 4 sites in United States
- Volunteers
- 239 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Coronary Artery Disease, Coronary Artery Stenoses
Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride
The aim of this study is to evaluate the analgesic efficacy and safety of wound infiltration with liposomal bupivacaine (LB) in patients undergoing cardiac surgery with sternotomy and cardiopulmonary bypass (CPB) and compare it…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenoses, Valve Regurgitation, Mitral, Valve Regurgitation, Tricuspid
- Trial name
- NCT03270514
- Testing
- Exparel Injectable Product, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kathirvel Subramaniam
Pain, Postoperative
Implementing Genomics in Practice (IGNITE): CYP2D6 Genotype-Guided Pain Management in Patients Undergoing Arthroplasty Surgery
This will be a randomized, open-labeled pilot pragmatic clinical trial. Patients undergoing arthroplasty surgery will be recruited from the University of Florida (UF) Health Gainesville and the Villages Orthopedic clinics for…
- Trial name
- NCT03534063
- Testing
- CYP2D6-guided opioid therapy
- Where
- 3 sites in United States
- Volunteers
- 260 people
- Sponsor
- University of Florida
Myringotomy
Effect of Dexmedetomidine on Emergence Agitation in Children With or Without Tube Insertion Under General Anesthesia
The investigators are inviting your child to participate in this research study because your child is having myringotomy (putting a tiny incision in the eardrum with or without tube insertion) under general anesthesia.
- Trial name
- NCT01535287
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Martin Mueller
Urinary Bladder, Neurogenic
A Study To Find Out How Fesoterodine Works In Children Aged 6 To 17 Years With Bladder Overactivity Caused By A Neurological Condition
The objective of the study is to find out if the medicine fesoterodine is a useful treatment in children with bladder muscle overactivity caused by a neurological condition. Children will be aged 6 to 17 years old.
- Trial name
- NCT01557244
- Testing
- Fesoterodine PR 4 mg, Fesoterodine PR 8 mg, Oxybutynin
- Where
- 84 sites in United States, Belgium and 23 more
- Volunteers
- 181 people
- Sponsor
- Pfizer
Pain, Postoperative, Amputation
Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations
Through this pilot prospective trial, we aim to obtain preliminary data investigating the effectiveness of perineural catheters and liposomal bupivacaine, both currently accepted as standard care at Maine Medical Center, for the…
- Trial name
- NCT05140499
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Aurora Quaye
Pain, Postoperative, Opioid Use
Management Of Pain After Cesarean Trial
This is a double blinded randomized controlled trial to test the efficacy of a combination of acetaminophen and ibuprofen administered to patients on schedule compared to ibuprofen alone on the patient's reported pain score on…
- Trial name
- MOPAC (NCT03929640)
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Milton S. Hershey Medical Center
Total Knee Arthroplasty
NEUROCUPLE™ in TKA Patients to Enhance Pain Management
This is a randomized (1:1) placebo-controlled clinical trial to determine the feasibility and effectiveness of 30-day application of NEUROCUPLE™ patch for pain reduction and opioid consumption following TKA.
- Trial name
- NCT06460350
- Testing
- NEUROCUPLE™ Patch
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- nCap Medical
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