Clinical trials: Neurologic Complication
Diabetic Neuropathy, Painful
Safety and Efficacy of AGN 203818 in Patients With Painful Diabetic Peripheral Neuropathy
This study will explore the safety and effectiveness of different doses of AGN 203818 in treating pain in patients with painful diabetic peripheral neuropathy
- Trial name
- NCT00381719
- Testing
- AGN 203818
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Allergan
Post-operative Pain, Total Hip Arthroplasty (THA)
Ultrasound Guided Lumbar Erector Spinae Block Using Bupivacaine - Magnesium Sulphate Versus Bupivacaine - Dexamethasone in Total Hip Replacement Surgery
The current study was done to evaluate the effect of adding dexamethasone and magnesium sulfate to bupivacaine as adjuvants in an ultrasound-guided erector spinae block for patients undergoing total hip arthroplasty (THA), and to…
- Conditions
- Post-operative Pain, Total Hip Arthroplasty (THA), Erector Spinae Plane Block
- Trial name
- NCT07418671
- Testing
- Bupivacaine-Magnesium Sulphate, Bupivacaine-Dexamethasone, Bupivacaine-Saline
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Skin Graft Complications, Pain Management
The Rule of Bupivacaine Hydrochloride in Skin Graft Donor Site
Split Thickness Skin Graft is frequently utilized for reconstructing skin loss of various causes. Unfortunately, the donor site of the STSG has an unavoidable, annoying post-operative pain
- Trial name
- NCT06766474
- Testing
- Bupivacain
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Post Operative Pain, Hemodynamic Instability
Intra-abdominal Pressure and Insufflator Effects in Robotic Surgery
The main aim of this study is to compare the perioperative effects of different intra-abdominal pressures and different insufflators in patients undergoing robotic surgery at a 30-45 degree trendelenburg position.
- Conditions
- Post Operative Pain, Hemodynamic Instability, Hypercapnia, Complication,Postoperative
- Trial name
- NCT06132490
- Testing
- Valveless Insufflator with 12 mmHg intra-abdominal pressure, Valveless Insufflator with 8 mmHg intra-abdominal pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Koç University
Diabetic Neuropathy
VEGF Gene Transfer for Diabetic Neuropathy
This gene therapy study is being conducted to evaluate intramuscular gene transfer using VEGF (Vascular Endothelial Growth Factor) in patients with diabetic neuropathy in the legs.
- Trial name
- NCT00056290
- Testing
- VEGF
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Losordo, Douglas, M.D.
Obstructive Sleep Apnea, Postoperative Respiratory Complications
A Multicenter Retrospective Analysis of Postoperative Respiratory Complications in Children With Obstructive Sleepapnea
This retrospective observational study aims to evaluate postoperative respiratory complications (PORC) after (adeno)tonsillectomy in children with OSA.
- Conditions
- Obstructive Sleep Apnea, Postoperative Respiratory Complications, Adenotonsillectomy, Child Obesity
- Trial name
- MRA PORC (NCT07305168)
- Where
- 2 sites in Belgium, Hungary
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Cholecystitis
Harmonic in Laparoscopic Cholecystectomy for Acute Cholecystitis
In the developmental stage of laparoscopic cholecystectomy it was considered 'unsafe' or 'technically difficult' to perform laparoscopic cholecystectomy for acute cholecystitis.
- Trial name
- HAC (NCT00746850)
- Testing
- early LC within 72 hours after the diagnosis with H (Harmonic), early LC within 72 hours after the diagnosis with MD (Monopolar Diathermy)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- University of Bologna
Postoperative Pain
Effect of Intraperitoneal Nebulisation of Magnesium Sulphate for Analgesia Following Laparoscopic Cholecystectomy
intraperitoneal nebulisation with magnesuim sulphate will reduce post operative pain and analgesic consumption in postoperative period following laparoscopic cholecystectomy.
- Trial name
- NCT01542697
- Testing
- intraperitoneal nebulisation of magnesium sulphate
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Postoperative Delirium (POD), Sex Differences
Sex-Dependent Risk of Postoperative Delirium and Mediating Effects of Family Visits
Postoperative delirium is a common and serious complication after surgery, affecting 10-40% of older patients undergoing non-cardiac procedures.
- Trial name
- NCT07502391
- Where
- Switzerland
- Volunteers
- 471 people
- Sponsor
- Julian Rössler
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Etoposide, Carboplatin, and Bleomycin in Treating Young Patients Undergoing Surgery For Malignant Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy, such as etoposide, carboplatin, and bleomycin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Ovarian Cancer
- Trial name
- NCT00276718
- Testing
- bleomycin sulfate, carboplatin, etoposide
- Where
- 22 sites in Ireland, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Children's Cancer and Leukaemia Group
Obesity, Postoperative Pain
Pregabalin in the Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy (LSG).
The aim of this clinical trial is to assess preemptive oral pregabalin administration in the obese patients undergoing laparoscopic sleeve gastrectomy.
- Conditions
- Obesity, Postoperative Pain, Postoperative Nausea and Vomiting, Opioid Use
- Trial name
- NCT05804591
- Testing
- Pregabalin 150mg
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Medical University of Warsaw
Serratus Plane Block, Postoperative Hyperalgesia
Effect of Liposome Bupivacaine Serratus Plane Block on Postoperative Hyperalgesia and Chronic Post-surgical Pain in Patients Undergoing Radical Mastectomy
Radical mastectomy is currently the mainstream surgical treatment for breast cancer. Patients often experience significant postoperative pain, and some may develop chronic pain.
- Conditions
- Serratus Plane Block, Postoperative Hyperalgesia, Chronic Post-surgical Pain, Liposomal Bupivacaine
- Trial name
- NCT07289178
- Testing
- Serratus Plane block (single injection)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
s100b, Hypoxia-Ischemia, Brain
Cord Blood S100B Protein Concentration in Neonates With Fetal Growth Restriction
S100B protein is a biomarker that increases following central nervous system (CNS) damage. Measuring this protein's levels may allow for the early identification of infants at high risk for developmental abnormalities, such as…
- Conditions
- s100b, Hypoxia-Ischemia, Brain, Fetal Growth Restriction (FGR)
- Trial name
- NCT06893926
- Testing
- Prenatal ultrasound examination with blood flow analysis, Umbilical cord blood gas analysis, Umbilical cord blood S100B protein level
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Irreversible Pulpitis
Effect of Conservative Root Canal Instrumentation on the Release of Inflammatory Mediators in Root Canal Treatments
The goal of this clinical trial is to evaluate the expression of inflammatory mediators in the crevicular fluid and periodontal ligament after one-visit root canal treatment of mandibular molars of patients with asymptomatic…
- Trial name
- NCT06237985
- Testing
- ProTaper Gold file system, OneShape file system, TruNatomy file system
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Postoperative Pain, Acute
Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries
Tourniquet, a compressing device, otherwise its use in intravenous regional anesthesia, is commonly used in particular orthopedic surgeries.
- Trial name
- K-IVRAg (NCT05543785)
- Testing
- Ketorolac, Control
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Mansoura University
Sarcopenia, Chronic Kidney Disease
Physical Rehabilitation and Chronic Kidney Disease
Older patients with chronic renal failure suffer from sarcopenia. Loss of muscle function is associated with increased morbidity and mortality. Currently few treatment are available.
- Conditions
- Sarcopenia, Chronic Kidney Disease, Older
- Trial name
- IMPREPA (NCT03671343)
- Testing
- Physical rehabilitation
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Surgical Complication, Pain, Postoperative
Anti-inflammatory Effect of Platelet-Rıch Fıbrın
This study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters.
- Conditions
- Surgical Complication, Pain, Postoperative, Edema Face
- Trial name
- NCT05336578
- Testing
- Platelet rich fibrin application
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nilay Er
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction in Heart Surgery
To determine the rate of Postoperative Cognitive Dysfunction (POCD) in the early and late postoperative periods by comparing the preop and postop period mini mental status tests in participants undergoing open heart surgery, and…
- Trial name
- NCT05406843
- Testing
- Preoperative cognitive functions of participants undergoing open heart surgery, Postoperative cognitive functions of particiants undergoing open heart surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kocaeli University
Magnetic Resonance Imaging, Hip Fractures
fMRI Feasibility Older Hip Fracture Surgery
An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery
- Conditions
- Magnetic Resonance Imaging, Hip Fractures, Postoperative Delirium
- Trial name
- NCT05081726
- Testing
- Functional MRI
- Volunteers
- 10 people
- Sponsor
- University of Nottingham
Postoperative Pain
Nalbuphine as an Adjuvant to Intravenous Regional Anesthesia
The effect of addition of nalbuphine to lidocaine in intravenous regional anesthesia
- Trial name
- NCT02678585
- Testing
- Nalbuphine, Lidocaine
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Assiut University
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