Clinical trials: Neurologic Complication
Pain, Postoperative, Postoperative Nausea and Vomiting
Differences in Incidence of Common Side Effects Between Young Adults and Elderly Patients While Using IV-PCA
In this retrospective study, postoperative pain score, PCA-related complications, the risk factors for requirement of rescue analgesics and antiemetics will be evaluated in young and elderly patients, respectively, using…
- Trial name
- NCT02448862
- Testing
- Fentanyl based IV-PCA
- Where
- South Korea
- Volunteers
- 10,575 people
- Sponsor
- Severance Hospital
Diabetic Neuropathy, Painful
Study to Assess Safety and Efficacy of Engensis in Painful Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the efficacy and safety of intramuscular administration of Engensis on pain in participants with painful diabetic peripheral neuropathy in the feet and lower legs, as compared to Placebo…
- Trial name
- REGAiN-1A (NCT04469270)
- Testing
- Engensis
- Where
- 16 sites in United States
- Volunteers
- 162 people
- Sponsor
- Helixmith Co., Ltd.
Endometriosis
Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain (EDELWEISS 6)
The primary objective of this extension study is to assess the maintenance of efficacy of linzagolix administered orally once daily for up to an additional 6 months (for up to 12 months of treatment in total) in women who have…
- Trial name
- NCT04335591
- Testing
- 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg)
- Where
- 47 sites in United States, Austria and 7 more
- Volunteers
- 356 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Postoperative Pain
Morphine Added to Ropivacaine for FICB for Postoperative Analgesia
prospective, randomized double blinded study to investigate the effects of morphine as an adjuvant to ropivacaine on FICB
- Trial name
- NCT03875274
- Testing
- Ropivacaine, Morphine, Ropivacaine, Saline
- Where
- Nepal
- Volunteers
- 70 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Sleep Apnea, Obstructive Sleep Apnea
Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea
The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Postoperative Complications
- Trial name
- NCT03109418
- Testing
- Ketamine, Control
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain, Postoperative, Narcotic Use
Bupivacaine for Post-operative Pain in Mohs
Mohs micrographic surgery (MMS) is regarded as the gold standard for the treatment of high-risk nonmelanoma skin cancer (NMSC). Pain after MMS peaks on the day of surgery and slowly decreases thereafter.
- Trial name
- NCT04362566
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Postoperative Pain
Single-shot TAP Block vs Continuous TAP Block
The purpose of this study is to determine whether continuous transversus abdominis plane (TAP) block is superior to single shot TAP for postoperative pain after laparoscopic donor nephrectomy
- Trial name
- TAP (NCT02475031)
- Testing
- TAP-C, TAP-S
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Indiana University
Pain, Postoperative, Medication Adherence
Evaluation of an Interactive Opioid Risk Education Program (STOMP) for Parents
Millions of children and adolescents are prescribed opioid pain relievers each year, placing them at risk for serious adverse events and misuse in the home setting.
- Conditions
- Pain, Postoperative, Medication Adherence, Opioid Use, Knowledge, Attitudes, Practice
- Trial name
- STOMP (NCT03287622)
- Testing
- Educational Intervention, Nudge
- Where
- United States
- Volunteers
- 712 people
- Sponsor
- University of Michigan
Scoliosis Idiopathic, Pain, Postoperative
Virtual Reality After Pediatric Scoliosis Surgery
The purpose of this study is to evaluate the use of virtual reality after scoliosis surgery in pediatric patients.
- Trial name
- VRAS-PS (NCT04584970)
- Testing
- Applied VR, Apple iPad
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Pain, Postoperative, Tooth Diseases
Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain
The primary objective of this study is to compare the efficacy of a combination product containing ibuprofen 400 mg and caffeine 100 mg versus either ingredient alone as well as placebo for the treatment of post-surgical dental…
- Trial name
- NCT01929031
- Testing
- ibuprofen + caffeine, ibuprofen, caffeine
- Where
- United States
- Volunteers
- 562 people
- Sponsor
- Boehringer Ingelheim
Postoperative Pain
Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy
This is a randomized, single blinded, placebo-controlled trial to study the effectiveness of a subanesthetic dose (0.6mg/kg) of ketamine versus placebo (saline) on postoperative pain on adult women undergoing mastectomy.
- Trial name
- NCT04831736
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- NYU Langone Health
Pain, Postoperative, Cesarean Section
Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section
The purpose of this prospective single center, randomized study is to determine if ultrasound guided Transversus Abdominis Plane (TAP), Quadratus Lumborum (QL), and Erector Spinae Plane (ESP) blocks decrease opioid consumption in…
- Trial name
- NCT03695172
- Testing
- Ropivacaine, TAP block, QL block
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Duke University
Knee Arthroplasty, Postoperative Pain
Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty
This study is conducted to evaluate the effectiveness and safety of ketamine infusion for pain relief after knee replacement surgery.
- Conditions
- Knee Arthroplasty, Postoperative Pain, Pain Management, Analgesia
- Trial name
- KETARTHRO (NCT07059429)
- Testing
- Ketamine, Standard Analgesia
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Postoperative Pain
Hydromorphone and C-section
This study will investigate the dose of hydromorphone which will relieve the pain of women following a cesarean section when delivered directly in the area around the spinal cord (i.e., intrathecal injection).
- Trial name
- NCT01598545
- Testing
- Hydromorphone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
Fabry Disease
Dosing Study of Replagal in Patients With Fabry Disease
This study will determine the safety and effectiveness of increasing Replagal infusions in certain patients with Fabry disease. Replagal is a genetically engineered form of Alpha-galactosidase A, an enzyme that normally breaks…
- Trial name
- NCT00068107
- Testing
- Replagal
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor Research Institute
Painful Diabetic Neuropathy
Efficacy and Safety Study of ARC-4558 for Management of Pain Associated With Painful Diabetic Neuropathy
The purpose of this study is to determine whether ARC-4558 is effective in managing pain associated with painful diabetic neuropathy.
- Trial name
- NCT00695565
- Testing
- Clonidine Topical Gel (ARC-4558)
- Where
- 16 sites in United States
- Volunteers
- 180 people
- Sponsor
- Arcion Therapeutics Inc
Postoperative Pain
Intravenous Acetaminophen in Craniotomy
The purpose of this study is to assess the use of intravenous Acetaminophen (OFIRMEV) as an effective adjunct therapeutic agent in patients undergoing craniotomy.
- Trial name
- NCT01598701
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Insomnia, End Stage Renal Disease
Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis
Insomnia is a common and distressing symptom for patients on hemodialysis (HD), and there is evidence for a much larger impact on the health of patients.
- Trial name
- Sleep-HD (NCT03534284)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Trazodone
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Washington
Emergence Delirium
Emergence Agitation Between Dexmedetomidine and Sevoflurane Anesthesia
Emergence agitation is commonly encountered after receiving inhalation anesthesia. This distressing phenomenon carries risks that are harmful to patients, caregivers and medical personnel.
- Trial name
- NCT06482125
- Testing
- Dexmedetomidine, Sevoflurane
- Where
- Indonesia
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Pelita Harapan University
Burning Pain, Impaired Balance
Feasibility Study of New Method of Diagnostic and Prediction of Painful CIPN
This clinical trial studies how well Diode laser fiber type Selective Stimulator (DLss) works in predicting pain development in patients with ovarian cancer who are receiving chemotherapy.
- Conditions
- Burning Pain, Impaired Balance, Malignant Ovarian Neoplasm, Numbness
- Trial name
- NCT03206216
- Testing
- Diode Laser fiber type Selective Stimulator (DLss)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
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