Clinical trials: Neurologic Complication
Failed Back Surgery Syndrome
SubQStim: A Post-market Study of Subcutaneous Nerve Stimulation in Failed Back Surgery Syndrome (FBSS) Patients
The purpose of this study is to compare the effectiveness of peripheral nerve stimulation utilizing a subcutaneous lead implant technique (SQS) plus optimized medical management (OMM) versus OMM alone in patients suffering from…
- Trial name
- NCT01711619
- Testing
- subcutaneous nerve stimulation, Optimized Medical Management
- Where
- 26 sites in Australia, Austria and 8 more
- Volunteers
- 162 people
- Sponsor
- MedtronicNeuro
Diabetic Neuropathy
A Safety and Efficacy Study for Tapentadol (CG5503) Extended Release for Patients With Painful Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of Tapentadol (CG5503) extended release (ER) (base) compared to placebo in patients with moderate to severe pain from diabetic…
- Trial name
- NCT00455520
- Testing
- CG5503
- Volunteers
- 395 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Chronic Low-back Pain, Postsurgical Pain
Postoperative Telehealth Mindfulness Intervention After Spine Surgery
Lumbar spine pain is the leading cause of years lived with a disability and affects over 50 million individuals in the United States.
- Conditions
- Chronic Low-back Pain, Postsurgical Pain, Opioid Use, Lumbar Spine Surgery
- Trial name
- NCT04648683
- Testing
- Individual telehealth mindfulness, Group telehealth mindfulness
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Endometriosis
Effects of Intravenous Lidocaine on Endometriosis Pain
We are doing this research study to find out if intravenous (in your vein, "IV") lidocaine can lessen pain from endometriosis. The U.S.
- Trial name
- NCT01968694
- Testing
- IV Lidocaine, IV diphenhydramine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Pain, Postoperative
Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery
A prospective, randomized comparison of bupivacaine to liposomal bupivacaine given by local injection at all the wound sites in patients undergoing robotic-assisted or laparoscopic urologic surgeries in an effort to determine…
- Trial name
- NCT02222129
- Testing
- Bupivacaine, liposomal bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 206 people
- Sponsor
- Knight, Richard, M.D.
Postoperative Pain
Continuous TAP Blocks: Relative Effects of a Basal Infusion vs. Repeated Bolus Doses
Single-injection transversus abdominis plane (TAP) blocks have been used to treat postoperative pain, and are become very popular within the United States because of their high analgesic potency and relative ease of placement.
- Trial name
- NCT02662023
- Testing
- Bolus, Basal
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Acute Pain, Arthropathy of Knee
NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Conditions
- Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative
- Trial name
- NCT03834142
- Testing
- NSS-2 Bridge
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jacques E. Chelly
Pain, Post-operative
Evaluation of N1539 Following Bunionectomy Surgery
The primary objective of this study is to evaluate the analgesic efficacy of N1539 in subjects with acute moderate to severe pain following unilateral bunionectomy.
- Trial name
- NCT02675907
- Testing
- N1539
- Where
- 4 sites in United States
- Volunteers
- 201 people
- Sponsor
- Baudax Bio
Neuropathy, Diabetic, Neuropathy;Peripheral
Clinical Efficacy and Human Factors Validation Testing of the Erchonia EVRL for Providing Temporary Relief of Diabetic Peripheral Neuropathy Foot Pain
The purpose of this clinical study is to determine the effectiveness of the Erchonia® EVRL™, manufactured by Erchonia Corporation (the Company), in providing prescription home use application for temporary relief of diabetic…
- Conditions
- Neuropathy, Diabetic, Neuropathy;Peripheral, Neuropathy, Painful
- Trial name
- NCT05291975
- Testing
- Erchonia® EVRL™
- Where
- 4 sites in United States
- Volunteers
- 64 people
- Sponsor
- Erchonia Corporation
Pain, Postoperative
Study Of The Efficacy And Safety Of Pregabalin Compared To Placebo For Treatment Of Post-Surgical Pain From Hysterectomy
To assess the efficacy of pregabalin compared to placebo on pain following hysterectomy , measured using subject reported assessments of pain.
- Trial name
- NCT00468845
- Testing
- pregabalin (Lyrica)
- Where
- 42 sites in United States, Canada and 7 more
- Volunteers
- 501 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Oocyte Retrieval, Postoperative Pain
Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction
The central objective of this study will be to evaluate the relationship between estrogen levels and the pain following oocyte retrieval in women undergoing in vitro fertilization.
- Trial name
- NCT03105518
- Testing
- Fentanyl, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Strabismus
Anesthetic Depth and the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery
This study evaluates the association between the depth of general anesthesia and the occurrence of emergence agitation (EA). The investigators hypothesized that optimal level of anesthetic depth could decrease the incidence of EA…
- Trial name
- NCT02521259
- Testing
- BIS
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Bundang Hospital
Neuropathic Pain, Phantom Pain
Neuropathic Pain After Orchidectomy and Sex Reassignment Surgery
Phantom pain is associated with cortical reorganization after amputation. This phenomenon should not play a role in transsexual women, since the cortical representation of the male sex organs is presumably altered.
- Conditions
- Neuropathic Pain, Phantom Pain, Sex Reassignment Surgery
- Trial name
- NPASRS (NCT04538170)
- Testing
- pain after surgery
- Where
- Germany
- Volunteers
- 423 people
- Sponsor
- University Hospital Tuebingen
Postoperative Pain, Bunions
Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy
A Phase 2, Randomized, Controlled, Multicenter, Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy
- Trial name
- NCT02762929
- Testing
- HTX-011A, HTX-011B, HTX-002
- Where
- 5 sites in United States
- Volunteers
- 430 people
- Sponsor
- Heron Therapeutics
Preeclampsia, Hypertension
Study of Positive Airway Pressure in Preeclampsia to Reduce Blood Pressure
The purpose of this study is to identify whether sleep-disordered breathing - as measured by overnight polysomnography - is associated with pre-eclampsia and to determine whether use of positive airway pressure can improve…
- Trial name
- NCT01029691
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Michigan
Pain, Postoperative, Anxiety
Healing Touch After Cesarean
Pain and anxiety are the most common complications after cesarean birth, and impair the mother's ability to optimally care for herself and her newborn.
- Conditions
- Pain, Postoperative, Anxiety, Postpartum Complication
- Trial name
- NCT05053360
- Testing
- Healing Touch, Control
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Inova Health Care Services
Impacted Mandibular Third Molar, Edema
Single-Session Extraoral PBM After Third Molar Extraction
Postoperative pain, edema, and trismus are frequent complications following impacted mandibular third molar surgery. This randomized controlled trial evaluated the effects of a single-session extraoral dual-wavelength…
- Conditions
- Impacted Mandibular Third Molar, Edema, Trismus, Postoperative Pain
- Trial name
- NCT07522918
- Testing
- Dual-wavelength GaAlAs laser (650+904 nm)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Chronic Pain, Post-operative Pain
Minocycline to Reduce Pain After Carpal Tunnel Release
The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.
- Trial name
- NCT02051296
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Hypertension, Pregnancy-Induced, Pre-eclampsia
The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy
To assess the effect of routine doses of ibuprofen on post-partum blood pressure control in women with gestational hypertension (gHTN) or preeclampsia without severe features (preE).
- Trial name
- NCT02891174
- Testing
- Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea, Fetal Growth Restriction
Sleep Apnea and Fetal Growth Restriction
This study aims to evaluate the association between obstructive sleep apnea (OSA) and fetal growth restriction (FGR) and to assess the role of auto-titrated positive airway pressure (aPAP) as antenatal therapy in these patients.
- Conditions
- Obstructive Sleep Apnea, Fetal Growth Restriction, Pregnancy Related
- Trial name
- SAFER (NCT04084990)
- Testing
- S9 VPAP Adapt
- Where
- 3 sites in United States, Israel
- Volunteers
- 3 people
- Sponsor
- Washington University School of Medicine
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