Clinical trials: Neurologic Complication
Postoperative Pain
Lumbar Paravertebral in Hernia Surgery
An inguinal hernia is one of the most common disorders requiring surgical repair in pediatrics. The effective treatment of postoperative pain in infants and children is challenging.
- Trial name
- NCT03408184
- Testing
- Lumbar paravertebral group, The field block group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Pain, Post-operative
Evaluation of N1539 Following Major Surgery
The primary objective of this study is to evaluate the safety and tolerability of N1539 in a variety of post-surgical conditions.
- Trial name
- NCT02720692
- Testing
- N1539
- Where
- 32 sites in United States, Australia and 2 more
- Volunteers
- 722 people
- Sponsor
- Baudax Bio
Premenstrual Syndrome, Pelvic Floor Disorders
The Effect of PVE Applied in Addition to Pilates on Premenstrual Symptoms, Pain, Sleep and QoL in Individuals With PMS
Premenstrual syndrome (PMS) is a condition that occurs with physical and psychological symptoms in the late luteal phase of the menstrual cycle in women and affects the physical and mental well-being of the individual.
- Conditions
- Premenstrual Syndrome, Pelvic Floor Disorders, Quality of Life
- Trial name
- NCT06191536
- Testing
- Pilates, Pelvic floor exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Glioblastoma, Glioblastoma Multiforme
The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients.
The trial is designed as a multicenter randomized controlled study. 246 patients with presumed Glioblastoma Multiforme in eloquent areas on diagnostic MRI will be selected by the neurosurgeons according the eligibility criteria…
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, Astrocytoma, Grade IV
- Trial name
- SAFE (NCT03861299)
- Testing
- Awake craniotomy, Craniotomy under general anesthesia
- Where
- 5 sites in Belgium, Netherlands
- Volunteers
- 246 people
- Sponsor
- Jasper Gerritsen
Pain, Postoperative
Sublingual Sufentanil Tablet System (SSTS) Versus Intravenous Patient Controlled Analgesia After Back Surgery.
In this study, numeric rating scale (NRS) and side effects are measured after usage of a sublingual sufentanil tablet system (SSTS) in comparison to intravenous patient controlled analgesia (PCIA).
- Trial name
- NCT03036514
- Testing
- Sublingual sufentanil tablet system, Patient-controlled intravenous analgesia
- Where
- Belgium
- Volunteers
- 27 people
- Sponsor
- University Hospital, Antwerp
Anesthesia Conduction, Upper Extremity Surgery
Comparison of Infraclavicular And Supraclavicular Block
Ultrasound-guided brachial plexus blocks are used successfully for upper extremity surgeries. In this randomized prospective single-blind study, ASA I-II patients aged 18-65 years undergoing hand, wrist, and forearm surgery will…
- Conditions
- Anesthesia Conduction, Upper Extremity Surgery, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- NCT04784104
- Testing
- Bupivacaine HCl 0.5% Injectable Solution, Prilocaine HCl 2% Injectable solution, Adrenaline amp. 0.5 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Bozyaka Training and Research Hospital
Diabetic Neuropathies, Chronic Pain
Optimization of NIBS for Diabetic Neuropathy Neuropathic Pain
The purpose of this study is to assess the effects of Transcranial Direct Current Stimulation (tDCS) in combination with Transcranial ultrasound (TUS) for the treatment of pain and functional limitations in subjects with Diabetic…
- Trial name
- NCT03625752
- Testing
- Active Comparator: Active tDCS + Active TUS
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Case Western Reserve University
Emergence Agitation
Transition to Propofol After Sevoflurane Anaesthesia to Prevent Emergence Agitation
The aim of this randomized double-blinded study is to determine whether transition to propofol for 3 min at the end of sevoflurane anaesthesia reduces the incidence of EA in children undergoing genito-urinary paediatric surgeries.
- Trial name
- NCT03179293
- Testing
- Propofol, Normal saline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Bone Cancer, Brain Cancer
Enhanced Assistance During Radiotherapy for Unmet Essential Needs
This is a prospective single-arm study of an enhanced assistance intervention for patients with unmet essential needs undergoing >10 fractions of radiotherapy comparing delay-free completion of radiotherapy in study participants…
- Conditions
- Bone Cancer, Brain Cancer, Colorectal Cancer, Esophagus Cancer
- Trial name
- EARN (NCT06582849)
- Testing
- Standard assistance, Enhanced assistance
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Postoperative Pain, Breast Cancer Surgery
Postoperative Pain, Central Sensitization, and Sleep Quality in Breast Cancer Surgery Patients
This prospective observational study aims to investigate whether preoperative central sensitization and sleep quality are associated with acute postoperative pain levels in patients undergoing breast cancer surgery.
- Conditions
- Postoperative Pain, Breast Cancer Surgery, Central Sensitization, Sleep Quality
- Trial name
- NCT07077421
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Istanbul University - Cerrahpasa
Postoperative Pain
The Impact of Chewing Gum on Postoperative Bowel Activity and Postoperative Pain After Total Laparoscopic Hysterectomy
Surgical interventions, such as restoring the health of patients and eliminating their existing symptoms, the surgical process can have many negative effects on the patient.
- Trial name
- NCT05135416
- Testing
- chewing gum Group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Anterior Cruciate Ligament Injuries, Postoperative Pain
Postoperative Analgesic Efficacy of ACB+iPACK vs FTB+Selective Tibial+Obturator Blocks in ACL Reconstruction
This prospective, comparative study aims to evaluate the postoperative analgesic efficacy of ultrasound-guided Adductor Canal Block (ACB) combined with iPACK block versus Femoral Triangle Block (FTB) combined with selective…
- Trial name
- ACL-Analgesia (NCT07702552)
- Testing
- Ultrasound-guided Adductor Canal Block (ACB), Ultrasound-guided iPACK block, Ultrasound-guided Femoral Triangle Block (FTB)
- Volunteers
- 100 people
- Sponsor
- Da Nang Hospital
Phenylketonuria, Maternal
A Global, Multicenter Study to Assess Maternal, Fetal and Infant Outcomes of Exposure to Palynziq® (Pegvaliase) During Pregnancy and Breastfeeding
This is a Phase 4 observational study designed to assess the impact of Palynziq ® (pegvaliase) treatment in pregnant women with PKU and on their offspring who were exposed to pegvaliase at any time during pregnancy and…
- Trial name
- PALomino (NCT05579548)
- Testing
- Pegvaliase
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 50 people
- Sponsor
- BioMarin Pharmaceutical
Preterm Birth, Pain, Acute
Reducing Pain During Heel Blood Collection in Preterm Newborns
Pharmacological and non-pharmacological methods are used to control interventional pain in preterm newborns. Non-pharmacological methods should be preferred in the management of pain, especially during painful minor invasive…
- Trial name
- NCT05431452
- Testing
- Pain management
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Chronic Headache, Nutcracker Phenomenon, Renal
Lumbar Vein Embolization for Chronic Headaches With Nutcracker Physiology
The purpose of this research is to gather information on the safety and feasibility of coiling the lumbar vein for the treatment of chronic headaches in patients with Nutcracker physiology and retrograde lumbar vein flow with…
- Conditions
- Chronic Headache, Nutcracker Phenomenon, Renal, Nutcracker Syndrome, Renal
- Trial name
- NCT06077747
- Testing
- Coil Embolization of the Lumbar Vein
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
FISTULA IN ANO
Comparison Between Laser and Open Fistula Surgeries in the Management of Fistula - In - Ano
This prospective randomized controlled trial compared the outcomes of laser versus open surgical techniques in the management of fistula-in-ano among 100 patients at a tertiary care center.
- Trial name
- NCT07083778
- Testing
- Laser Fistula Surgery (FiLaC - Fistula-tract Laser Closure), Open Fistula Surgery (Fistulotomy, Fistulectomy, or LIFT Procedure)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- GSVM Medical College
Postoperative Delirium
Naples Prognostic Score for Predicting Postoperative Delirium
Naples Prognostic Score (NPS) originally developed to predict outcomes in inflammatory and malignant conditions; we asked if it can effectively predict postoperative delirium (POD) in elderly patients undergoing hip surgery? NPS…
- Trial name
- NCT07297017
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- South Valley University
Dysmenorrhea, Endometriosis
Effect of Melatonin on Reduction of Pelvic Pain
In two double blinded randomized controlled trials (RCT) we will study the effect of pain reduction of melatonin vs placebo in women with severe dysmenorrhea and women with endometriosis.The aim is to find an effective method for…
- Trial name
- NCT03782740
- Testing
- Melatonin 10 mg, Melatonin 20 mg
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Postoperative Pain, Acute
Effectiveness of Fentanyl-Added TAP Block in Laparoscopic Cholecystectomy
The aim of this study is to evaluate the effectiveness of adding fentanyl to the TAP block in laparoscopic cholecystectomy cases.
- Trial name
- NCT06778668
- Testing
- TAP block with bupivacaine only, TAP block with bupivacaine and fentanyl
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Uludag University
Postoperative Pain
Prospective Randomized Comparison of Clinical Results of Hand Assisted Laparoscopic Splenectomies and Open Splenectomies
ABSTRACT Background: Although there are some comparative studies between laparoscopy and hand-assisted laparoscopic splenectomy (HALS) in splenomegaly cases, there is no study of the differences between HALS and open splenectomy…
- Trial name
- NCT00754806
- Volunteers
- 27 people
- Sponsor
- Istanbul University
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