Clinical trials: Neurologic Complication
Postoperative Delirium
Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery
Postoperative delirium (POD) is the most common adverse neurologic complication that can occur in patients of any age. Its incidence varies across age groups and is substantially influenced by patient-related risk factors.
- Trial name
- NCT04707794
- Testing
- Sevoflurane, Desflurane
- Where
- 2 sites in India
- Volunteers
- 270 people
- Sponsor
- Sir Ganga Ram Hospital
Premature Infant
Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS)
The Early Prediction Study is a longitudinal population-based cohort study for very preterm infants ≤32 weeks gestational age. Preterm infants recruited from three greater Cincinnati and two Dayton area neonatal intensive care…
- Trial name
- NCT03345069
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy
Evaluating The Use of CGF Made Gel in Mandibular Extraction Sites of Lower Impacted 3rd Molars.
The goal of this clinical trial is to learn if Concentrated Growth Factor (CGF) Gel help improve bone healing and reduce pain after the surgical removal of impacted lower third molars.
- Conditions
- Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy, Postoperative Pain Management in Oral Surgery, Concentrated Growth Factor for Extraction Socket Healing
- Trial name
- CGF (NCT07520097)
- Testing
- Concentrated Growth Factor (CGF) Gel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sleep Disorder, Polycystic Ovarian Syndrome (PCOS)
Association Between Polycystic Ovary Syndrome and Sleep Quality: A Questionnaire-Based Study
This cross-sectional study enrolled 310 women with PCOS (Rotterdam criteria) at a tertiary referral center between September 2025 and January 2026.
- Trial name
- PMOS (NCT07898423)
- Where
- Turkey (Türkiye)
- Volunteers
- 290 people
- Sponsor
- Tepecik Training and Research Hospital
Pain, Postoperative
Opioids Following ACL
The purpose of this study is to evaluate the effectiveness of a post-operative opioid pain 18 management protocol for anterior cruciate ligament reconstruction (ACLR).
- Trial name
- NCT04278703
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Rothman Institute Orthopaedics
Adolescent Idiopathic Scoliosis, Respiratory Depression
Anesthetic Optimization in Scoliosis Surgery
The standard anesthetic care plan for people having adolescent idiopathic scoliosis surgery will be accompanied by a pharmacokinetic simulation of the administered drugs to suggest opportunities to adjust drug doses to achieve…
- Conditions
- Adolescent Idiopathic Scoliosis, Respiratory Depression, Postoperative Pain
- Trial name
- AIS (NCT02481570)
- Testing
- pharmacokinetic simulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Laminectomy, Post-laminectomy Syndrome
Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
Traditionally, pain relief through spinal cord stimulation has been associated with the appearance of paresthesia in the affected area.
- Conditions
- Laminectomy, Post-laminectomy Syndrome, Spinal Cord Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT03702010
- Testing
- spinal cord stimulation conventional, spinal cord stimulation experimental
- Where
- 2 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Pain, Postoperative, Adult
Longitudinal Assessment of Pain-Related Patient-Reported Outcomes After Surgery
Little is known about pain-related outcomes experienced by patients in the first few weeks after surgery, once they are discharged from hospital.
- Conditions
- Pain, Postoperative, Adult, Pain Measurement, Functional Status
- Trial name
- NCT05315596
- Where
- 16 sites in Germany, Mexico
- Volunteers
- 1,000 people
- Sponsor
- Jena University Hospital
Preterm Birth, Low Birthweight Neonate
Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial
The ground-breaking Prevention of Prematurity and Xylitol (PPaX) cluster randomized controlled clinical trial was conducted in Lilongwe, Malawi and enrolled approximately 10,069 pregnant individuals seeking to evaluate the impact…
- Conditions
- Preterm Birth, Low Birthweight Neonate, Periodontitis, Gingivitis
- Trial name
- XaPPP (NCT07424846)
- Testing
- Xylitol Chewing gum, Sorbitol chewing gum
- Where
- Malawi
- Volunteers
- 6,000 people
- Sponsor
- University of Washington
Sedation Complication
multipaRameter mOnitoring systeM for sedAtion iNThe ICu
The administration of sedation in Intensive Care Units (ICU) is a vital and complex task, essential for the well-being of critically ill patients.
- Trial name
- ROMANTIC (NCT06667869)
- Testing
- Sedative
- Where
- 2 sites in Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Lumbar Disc Disease, Epidural Fibrosis
The Effect of Mediclore as an Anti-adhesion Agent and Safety in Full-endoscopic Spine Surgery: a Preliminary Study
The goal of this clinical trial is to compare efficacy and safety of Mediclore as anti-adhesion agent in patient who undergo endoscopic lumbar discectomy.
- Conditions
- Lumbar Disc Disease, Epidural Fibrosis, Failed Back Surgery Syndrome
- Trial name
- NCT06034041
- Testing
- Mediclore, Normal Saline
- Where
- Thailand
- Volunteers
- 78 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Diabetic Neuropathies
tSCS and AR on Pain and Balance in Diabetic Peripheral Neuropathy
tSCS and AR-based training have individually shown benefits in neuromotor rehabilitation; no study to date has evaluated their combined effects on pain, balance, lower-limb strength, retention, and vibration sense in diabetic…
- Trial name
- NCT07619794
- Testing
- transcutaneous spinal cord stimulation, Augmented Reality
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Emergence Agitation
Effects of Preoperative Child and Parental Anxiety on Emergence Agitation
Investigation of the effect of preoperative parental anxiety and sociodemographic characteristics on emergence agitation in patients undergoing pediatric adenotonsil surgery
- Trial name
- NCT07486427
- Testing
- No intervention - observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Ondokuz Mayıs University
Pain, Postoperative, Arthroplasty Complications
Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty
Prospective randomized double blinded, placebo controlled study that will evaluate the effect of intra-operative ketamine administration on post-operative analgesic requirements and self-reported pain in patients undergoing total…
- Trial name
- NCT04437888
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Dyspareunia, Pain
Effects of Myofascial Release With and Without Thiele Massage
Dysperunia is caused by chronic discomfort during sexual intercourse causing pain during vaginal intercourse.Sexual pain causes relationship decreasing quality of life following anxiety and depression.Myofascial techniques with…
- Conditions
- Dyspareunia, Pain, Quality of Life
- Trial name
- NCT05834088
- Testing
- Myofascial release techniques, Thiele massage
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Postoperative Pain
Comparing Two Root Canal Cleaning Solutions (Chlorhexidine vs. Sodium Hypochlorite) for Pain After Treatment
Brief Summary (A short description for the lay public) This study aims to find out if the type of cleaning solution used during a root canal affects the pain a patient feels the next day.
- Trial name
- CHXvsNaOCl-Pai (NCT07453160)
- Testing
- Chlorhexidine gluconate 2%, Sodium hypochlorite 5.25%
- Volunteers
- 90 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Pain, Postoperative, Opioid Use
Therapeutic Efficacy of Intravenous Lidocaine Infusion Compared With Epidural Analgesia for Postoperative Pain Control in Adult Patients Undergoing Major Abdominal Surgery: Non-Inferiority Clinical Trial
Major abdominal surgery continues is one of the most performed surgical procedures in the world, both electively and urgently. One of the main problems of this type of intervention is postoperative pain.
- Trial name
- NCT04017013
- Testing
- Epidural Analgesia, Lidocaine Infusion
- Where
- Colombia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill tumor cells.
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Liver Cancer
- Trial name
- NCT00007813
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Postoperative Pain
Acupuncture for Postoperative Pain After Abdominal Surgery for Gynecological Diseases
Objectives: To examine the efficacy and safety of electroacupuncture (EA) combined with auricular acupuncture (AA) in reducing post-operative pain in patients following abdominal surgery for gynecological diseases.
- Trial name
- NCT02851186
- Testing
- Acupuncture
- Where
- 2 sites in Hong Kong
- Volunteers
- 72 people
- Sponsor
- The University of Hong Kong
Postoperative Complications, Postoperative Delirium
Acupoint Stimulation Improve Postoperative Delirium in Elderly Patients
Postoperative delirium is with increased incidence in elderly patients. Previous studies have shown that acupuncture related techniques could induce protection against brain ischemia and improve outcome after cerebral diseases.
- Trial name
- AICE (NCT03726073)
- Testing
- Transcutaneous acupoint electrical acupoint stimulation(TEAS) and auricular acupressure, Usual care
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Air Force Military Medical University, China
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