Clinical trials: Neurologic Deficits
Subarachnoid Hemorrhage
Preconditioning for Aneurismal Subarachnoid Hemorrhage
In remote preconditioning, ischemia in one organ protects distant organs from ischemic insults. e.g. brief induced limb ischemia protects the brain from an otherwise more severe stroke.
- Trial name
- NCT01110239
- Testing
- remote limb preconditioning
- Volunteers
- 34 people
- Sponsor
- University of Miami
Urologic Diseases, Gastrointestinal Diseases
PACT Programme for Parents of Children With SHCN
This randomised controlled trial aims to determine the efficacy of a 12-week, smartphone-based Prosocial-orientated Acceptance and Commitment Training (PACT) programme plus age-appropriate positive parenting advice on the…
- Conditions
- Urologic Diseases, Gastrointestinal Diseases, Vascular Diseases, Cleft Lip and Palate
- Trial name
- NCT05467527
- Testing
- Prosocial-orientated Acceptance and Commitment Training plus positive parenting advice, Positive parenting advice
- Where
- 2 sites in Hong Kong
- Volunteers
- 196 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Injury, Knee Injuries
Sensory Deficit Following ACL Reconstruction: PRF Pilot Study
Pilot, single-center, non-randomized, parallel-group clinical study designed to assess whether intraoperative application of autologous platelet-rich fibrin (PRF) at the bone-patellar tendon-bone (BPTB) donor site reduces…
- Conditions
- Anterior Cruciate Ligament Injury, Knee Injuries, Sensory Disorders, Bone-Patellar Tendon-Bone Autograft
- Trial name
- PRF-ACL (NCT07257666)
- Testing
- Platelet-rich fibrin (PRF), Standard Closure (Control)
- Where
- Serbia
- Volunteers
- 53 people
- Sponsor
- University of Belgrade
Memory Deficits
Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults
This study was designed to characterize the changes in the brain and body associated with whole coffee cherry extract (WCCE). WCCE is a patented extract of whole coffee fruit (coffee berries) from coffea arabica.
- Trial name
- NCT03812744
- Testing
- Whole coffee cherry extract (WCCE)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Auburn University
Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury
The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery
Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury, Congenital Heart Defect
- Trial name
- NCT06899971
- Testing
- Collecting discarded blood samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Attention Deficit Hyperactivity Disorder (ADHD), Anxiety Disorders and Symptoms
Safety and Efficacy of Mexidol® for ADHD in Children Aged 6-12
The primary objective of this study was to evaluate the efficacy and safety of Mexidol® film-coated tablets (125 mg) compared to a placebo in children aged 6 to 12 years with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- MEGA (NCT06854601)
- Testing
- Mexidol
- Where
- 14 sites in Russia
- Volunteers
- 333 people
- Sponsor
- Pharmasoft
Single Level Stable Thoracolumbar Fracture Type AO A3, Multiple Level Stable Thoracolumbar Fracture Type AO A3
Spine FA3 - a Prospective, International, Multicenter Cohort Study on Treatment of of AO A3 Thoracolumbar Fractures
Thoracolumbar fractures are the most common spinal fractures with an average annual incidence between 18 and 30 per 100'000 inhabitants. The majority of these fractures are AO type A3 ("burst fractures").
- Trial name
- FA3 (NCT01751633)
- Testing
- Surgical, Conservative treatment
- Where
- 8 sites in Brazil, Chile and 4 more
- Volunteers
- 38 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Stroke
Simultaneous Recording of Cognitive and Motor Functions After Stroke
Aim: To assess whether a cognitively demanding dual-task has greater impact on manual dexterity in chronic stroke patients than in healthy subjects.
- Trial name
- SACSO (NCT05454748)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Depressive Disorder, Treatment-Resistant, Memory Deficits
SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression
The goal of this clinical trial is to learn whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®), a type of transcranial magnetic stimulation (TMS), is safe and may improve memory and thinking in adults aged…
- Trial name
- NCT07876908
- Testing
- Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®) with the Magnus Neuromodulation System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- BrainHealth Solutions, Inc.
Tourette Syndrome, Tourette's Disorder
Assessment of Children With Tic Onset in the Past 6 Months
The purpose of this research is to study why most children who have tics never develop Tourette syndrome but some do. In other words, we aim to find features that may predict whose tics will go away and whose tics will continue…
- Conditions
- Tourette Syndrome, Tourette's Disorder, Chronic Motor or Vocal Tic Disorder, Transient Tic Disorder
- Trial name
- NewTics (NCT01177774)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Washington University School of Medicine
Stroke, Gait Disorders, Neurologic
ZEPU AI9 Exoskeleton Rehabilitation Robot
The goal of this clinical trial is to learn whether the ZEPU AI9 lower limb exoskeleton robot is feasible, safe, and effective for people with walking difficulty caused by stroke, incomplete spinal cord injury, or orthopedic…
- Conditions
- Stroke, Gait Disorders, Neurologic, Spinal Cord Injuries, Incomplete, Postoperative Complication
- Trial name
- NCT07750808
- Testing
- ZEPU-AI9 Lower Limb Exoskeleton Gait Training, Standard-of-Care Rehabilitation
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University
Elbow Fracture, Neurologic Deficits
Fracture and Neurological Injury
The goal of the project is to describe novel factors affecting outcome after elbow fracture surgery with an in-depth evaluation of the role played by neuro inflammation from concomitant peripheral nerve injury or head injury in…
- Trial name
- FIRE (NCT05075382)
- Testing
- Elbow surgery for fracture
- Sponsor
- Université de Montréal
Neurologic Deficits
Investigation of Motor Imagery Ability in Relation to Body Awareness and Joint Position Sense in Healthy Subjects
Motor imagery (MI) is a dynamic mental state in which representations of a specific motor movement are rehearsed in working memory without any movement manifestation.
- Trial name
- MI-BA-JPS (NCT07445165)
- Testing
- Movement Imagery Questionnaire-3 (MIQ-3), Vividness of Movement Imagery Questionnaire-2 (VMIQ-2), The Recognise™
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Brain Damage
Rehabilitation Treatment of Time Deficits in Brain-damaged Patients
The efficacy of an innovative rehabilitation treatment for deficit in time processing is tested in right brain damaged patients.
- Trial name
- NCT04373837
- Testing
- Prismatic googles inducing prismatic adaptation (PA) associated to Virtual Reality (VR), Neutral googles inducing no-adaptation (NA) associated to Virtual Reality (VR)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Epilepsy, Cognitive Deficits
Methylphenidate Treatment of Attention Deficits in Epilepsy
Methylphenidate (MPH) has long been used to improve attention and cognitive difficulties associated with ADHD, including in children with ADHD and epilepsy (Torres et al., 2008).
- Conditions
- Epilepsy, Cognitive Deficits, Attention Deficits
- Trial name
- NCT02178995
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kimford Jay Meador
Attention Deficit Disorder With Hyperactivity, Autistic Disorder
Methylphenidate in Children and Adolescents With Pervasive Developmental Disorders
This study will evaluate the efficacy and safety of methylphenidate for treating hyperactivity, impulsiveness, and distractibility in 60 children and adolescents with Pervasive Developmental Disorders (PDD).
- Conditions
- Attention Deficit Disorder With Hyperactivity, Autistic Disorder, Pervasive Development Disorders
- Trial name
- NCT00025779
- Testing
- methylphenidate, guanfacine
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Traumatic Brain Injury
Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI
Deficits in memory, attention, cognitive, and executive functions are the most common disabilities after traumatic brain injury (TBI).
- Trial name
- NCT02148783
- Testing
- methylphenidate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Uniformed Services University of the Health Sciences
Brain Injury, Cognitive Deficits
Analysis of TCLT in TBI Patients: a Prospective, Randomized Controlled Trial
The purpose of this study is to evaluate the early and late effects of Transcranial Led Therapy (TLTC) in memory and executive functions in patients with moderate and severe TBI history (TBI time longer than 3 months).
- Trial name
- NCT02393079
- Testing
- Transcranial LED Therapy (TCLT)
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo General Hospital
Motor Deficits, Lumbar Discectomy
Investigation of Preoperative Factors Influencing the Outcome of Motor Deficits in Patients Undergoing Lumbar Microdiskectomy
Lumbar disc herniations may result in lower limb weakness. In such cases, there is a strong indication for surgical intervention through microdiscectomy.
- Conditions
- Motor Deficits, Lumbar Discectomy, Muscle Weakness, Paresis
- Trial name
- NCT07413302
- Where
- 3 sites in Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Stroke, Relatives
Can Stroke Patients and Their Caregiver Benefit From Additive Mindfulness Training
The main purpose of the study is to find out if MBSR (Mindfulness) in addition to occupational therapy, can improve the therapeutic results in stroke-patients and help relatives of stroke patients to improve their quality of life.
- Conditions
- Stroke, Relatives, Motor Disorder, Attention Deficit
- Trial name
- NCT03271788
- Testing
- Mindfulness, MBSR
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Zurich University of Applied Sciences