Clinical trials: Neurologic Findings
Electroencephalogram, Postoperative Delirium
Correlation of Electroencephalogram With Postoperative Delirium During Cardiac Surgery
The purpose of this study is to explore characteristic changes of EEG epileptiform discharges in patients under CPB and correlation with POD
- Trial name
- NCT04943939
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Ningxia Medical University
Sickle Cell Disease (SCD)
Self-administered Acupressure in Patients With Sickle Cell Disease
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupressure analgesia in patients with sickle cell disease (SCD).
- Trial name
- NCT07875777
- Testing
- Verum Acupressure (using AcuWand)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Cincinnati
Huntington Disease, Tardive Dyskinesia
A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in Healthy Subjects
This is a single-center, randomized, double-blinded, placebo-controlled, dose escalation trial to evaluate the safety, tolerability and pharmacokinetic of LPM3770164 sustained-release tablets orally administered in healthy…
- Trial name
- NCT05238701
- Testing
- LPM3770164 sustained release tablet, LPM3770164 sustained release tablet simulant
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Sarcopenia, Osteoporosis
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.
- Conditions
- Sarcopenia, Osteoporosis, Aging
- Trial name
- NCT01083901
- Testing
- Resistance training
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Endometriosis
Endometriosis Trial: Study of NBI-56418 in Endometriosis
This is a Phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study with subjects randomized to one of three treatment groups, placebo, 75 mg and 150 mg in a 1:1:1 ratio.
- Trial name
- NCT00109512
- Testing
- NBI-56418 (GnRH antagonist)
- Where
- 15 sites in United States
- Volunteers
- 76 people
- Sponsor
- Abbott
Sickle Cell Disease, Sickle Cell Crisis
Optimal Timing of Ketamine Initiation for SCD Pain
The goal of this clinical trial is to learn if the use of early ketamine decreases the chance of admission to the hospital in patients with sickle cell disease presenting with pain.
- Trial name
- NCT07450430
- Testing
- Ketamine hydrochloride injection
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Boston Children's Hospital
Intractable Pain, Intensive Care
Ketamine and Refractory Painful Care in a Palliative Unit
Pain is one of the major symptoms in palliative care units and often is very difficult to treat, being considered as a refractory pain.
- Conditions
- Intractable Pain, Intensive Care, Pressure Ulcer, Pain Management
- Trial name
- KETAREF (NCT02587130)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Lille Catholic University
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer
RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00726830
- Testing
- methadone hydrochloride, morphine sulfate, oxycodone hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Dizziness, Balance; Distorted
Effects of Gaze Stabilization Exercises on Dizziness, Balance and Quality of Life in Cervical Spondylosis Patients
To determine the effects of gaze stabilization exercises on dizziness, balance and quality of life in patients with cervical spondylosis.
- Conditions
- Dizziness, Balance; Distorted, Cervical Spondylosis
- Trial name
- NCT05707130
- Testing
- gaze stabilization exercises, neck isometrics
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Healthy
Effect of Neutralization of Endogenous Acid Production on BMD and Bone Microarchitectural
Hypothesis: Neutralization of acid production induced by the Western diet with oral administration of potassium citrate increases bone mineral density and bone mass as well as skeletal muscle mass and strength in elderly people…
- Trial name
- NCT00509405
- Testing
- potassium citrate
- Where
- Switzerland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baselland Bruderholz
Neck Pain
Risk Factors and Risk Profiles for Persistent Neck Pain in Young Adults: Results From the HUNT Study
Neck pain is one of the most prevalent musculoskeletal disorder in Norway among older adolescents and young adults. Despite this, little research exist on risk factors for neck pain in the transitional life phase from adolescence…
- Trial name
- NCT04201366
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 8,562 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Lung Transplant; Pain
Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation
The goal of this pilot trial is to learn whether the use of cryo nerve block and its effect on sensation in the chest alters recovery after bilateral lung transplantation, and to which extent these parameters are influenced.
- Trial name
- CRyoLTRiX (NCT06959056)
- Testing
- cryo nerve block at T3-T8 intercostal nerves bilaterally
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Gasthuisberg
Chronic Pain, Insomnia
The Efficacy of CALPXT96™in Improving Sleep Quality in Patients With Chronic Non-cancer Pain
California Poppy has been traditionally used in Herbal Medicine as an analgesic, mild sedative and/or sleep aid. However there are no human clinical trial data to support its use.
- Trial name
- CALPXT96 (NCT02232256)
- Testing
- CALPXT96
- Where
- Canada
- Sponsor
- 9305-9954 Quebec Inc
Muscle Loss, Extracellular Fluid Alteration
Ultrasound Detection of Body Composition in Critical Care
Objective assessment of the Changes in body composition of critically ill patients is very valuable. Ultrasound stands as a solution due to its portability, bedside availability, and radiation-free technology.
- Conditions
- Muscle Loss, Extracellular Fluid Alteration, Critical Illness, Pregnancy Complications
- Trial name
- NCT06728722
- Testing
- ultrasound detection of body composition
- Where
- Egypt
- Volunteers
- 121 people
- Sponsor
- Ain Shams University
Spastic Diplegia
Phase II Randomized Study of Selective Dorsal Rhizotomy and Physiotherapy Vs Physiotherapy Alone for Spastic Diplegia
OBJECTIVES: I. Assess the efficacy and safety of selective dorsal rhizotomy and physiotherapy compared with physiotherapy alone in improving gross motor function and reducing spasticity in children with spastic diplegia.
- Trial name
- NCT00004751
- Testing
- Surgery, Physical therapy
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neurotoxicity, Pain
Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
RATIONALE: Lamotrigine may be effective in reducing pain, numbness, tingling, and other symptoms of peripheral neuropathy. It is not yet known whether lamotrigine is effective in treating peripheral neuropathy caused by…
- Conditions
- Neurotoxicity, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00068445
- Testing
- lamotrigine
- Where
- 23 sites in United States
- Volunteers
- 131 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Retinopathy of Prematurity, Retinal Detachment
Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity
The purpose of this study is to test whether ACULAR, a nonsteroidal anti-inflammatory eye drop medication, can prevent the development of retinopathy of prematurity (ROP) and/ or decrease its severity.In this study ACULAR will be…
- Conditions
- Retinopathy of Prematurity, Retinal Detachment, Blindness
- Trial name
- ROP (NCT00634972)
- Testing
- ACULAR, REFRESH TEARS
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Migraine
A Study of LY2951742 (Galcanezumab) in Japanese Participants With Episodic Migraine
The main purpose of this study is to determine the efficacy of the study drug Galcanezumab in Japanese participants with episodic migraine.
- Trial name
- NCT02959177
- Testing
- Galcanezumab
- Where
- 47 sites in Japan
- Volunteers
- 459 people
- Sponsor
- Eli Lilly and Company
Spinal Cord Injuries, Neurogenic Bladder
Intravesical Lactobacillus to Reduce Urinary Symptoms After Spinal Cord Injury
The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable…
- Trial name
- NCT04373512
- Testing
- Culturelle 10 Billion CFU Capsule (2 doses), Culturelle 10 Billion CFU Capsule (4 doses)
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- Medstar Health Research Institute
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