Clinical trials: Neurologic Findings
Learning Disabilities
Action Medical Research
Learning disability affects 3% of the population. Severe types of learning disability are more likely to have an underlying genetic cause but diagnosis is difficult because many different genetic abnormalities may be involved.
- Trial name
- NCT02227381
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- Manchester University NHS Foundation Trust
Disorder of Consciousness
rTMS and EEG in DOC Patients
Background: Severe brain injury could cause chronic disorders of consciousness (DOC). Treating DOC patients to improve recovery remains very challenging.
- Trial name
- NCT04401319
- Testing
- DLPFC Stimulation for Crossover Study, AG Stimulation for Crossover Study, DLPFC Stimulation for Parallel Study
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 90 people
- Sponsor
- University of Liege
Fibromyalgia
Mindfulness Intervention for Fibromyalgia Delivered Through a Smartphone App
The purpose of this pilot feasibility study is to evaluate the effects of a smartphone-based mindfulness intervention (MBI) on pain-related outcomes in individuals with fibromyalgia.
- Trial name
- Fibroapp (NCT07032519)
- Testing
- Mindfulness Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Brigham and Women's Hospital
Acute Pain
Open Label Placebo to Reduce Prescription Opioid Use
The goal of the proposed study is to examine the efficacy of using an honest placebo to relieve pain for patients with an acute pain condition.
- Trial name
- NCT05014230
- Testing
- Opioid medication as part of standard care
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Brown University
Neuropathic Pain
The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
Pain as a result of nerve injury (neuropathic pain) is a particularly severe form of chronic pain. Common examples of neuropathic pain are pain due to diabetes and shingles.
- Trial name
- NCT01669967
- Testing
- Lidocaine, Diphenhydramine
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Infant Development, Hemiplegia
CIMT and taVNS for Hemiplegia in Infants
Newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body.
- Conditions
- Infant Development, Hemiplegia, Constraint Induced Movement Therapy
- Trial name
- NCT05101707
- Testing
- transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical University of South Carolina
ADNP, Helsmoortel-Van Der Aa Syndrome
ADNP Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing ADNP-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
ADNP, also known as Activity Dependent Neuroprotective Protein, is a rare neurodevelopmental disorder caused by mutations encompassing the ADNP gene on chromosome 20.
- Conditions
- ADNP, Helsmoortel-Van Der Aa Syndrome, Autism Spectrum Disorder
- Trial name
- NCT03718936
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Vision Disorder
A Novel Acuity Testing Method
The purpose of this protocol is to develop a valid, reliable, better standardized, and more efficient test of visual acuity (ability to see fine details) for use in clinical trials.
- Trial name
- NCT00013936
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Eye Institute (NEI)
Back Pain, Low
Pilates in Women With Chronic Low Back Pain
The purpose of this study is to evaluate the effect of a Pilates exercise program (PEP) on the flexo-relaxation ratio (FRR) of the erector spinae (ES) muscle during standing maximal trunk flexion/extension in women with chronic…
- Trial name
- NCT05264311
- Testing
- Pilates exercise program
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Parkinson's Disease, Progressive Supranuclear Palsy(PSP)
Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers
This research employs AI to analyze facial expressions and speech patterns, aiming to develop new digital tools for diagnosing and differentiating Parkinson's disease and similar disorders.
- Conditions
- Parkinson's Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy, Healthy Control
- Trial name
- NCT07392411
- Testing
- video recording
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Autism Spectrum Disorder, Autism
Halliwick Hydrotherapy and Snoezelen
The aim of this study was to evaluate the effectiveness of the Halliwick concept in the adapted Snoezelen multi-sensory environment, in the gross mobility of children belonging to the autism spectrum.
- Conditions
- Autism Spectrum Disorder, Autism, Sensory Disorder
- Trial name
- NCT05134844
- Testing
- Hydrotherapy- Snoezelen, Snoezelen
- Where
- Greece
- Volunteers
- 53 people
- Sponsor
- University of Thessaly
Memory Disorders
Study of the Brain Stimulation Effect on Memory Impairment in Alzheimer Disease
Alzheimer's Disease (AD) is the most common cause of dementia. Today no treatment had shown consistent efficacy to stop or slow down the disease.
- Trial name
- NCT00947934
- Testing
- Deep brain stimulation
- Where
- 2 sites in France
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Pain
Ganglion Impar Denervation and Radiofrequency on Sacral Root 3 for Chronic Prostatic Pain
the authors will evaluate the added analgesic benefit of pulsed radiofrequency on sacral root 3 with ganglion impar denervation on chronic pelvic pain due to chronic prostatitis
- Trial name
- NCT03884764
- Testing
- pulsed radiofrequency, ganglion impar denervation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Mood
Sub-chronic Effects of 5-hydroxytryptophan on Mood and Emotional Processing in Healthy Volunteers
5-hydroxytryptophan (5-HTP) is a nutritional supplement sold in many health food stores, and is taken in order to raise levels of serotonin in the brain. Serotonin is a neurotransmitter that is involved in the regulation of mood.
- Trial name
- NCT01514409
- Testing
- 5-Hydroxytryptophan, Pharmaceutical grade silica
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Dementia, Early Onset, Alzheimer Dementia (AD)
Genetic Studies of Early-onset Dementia
The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease…
- Conditions
- Dementia, Early Onset, Alzheimer Dementia (AD), Mild Cognitive Impairment (MCI), Memory Loss
- Trial name
- NCT04906863
- Testing
- Blood draw, Neurocognitive testing, Medical questionnaire
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hearing Impairment
Use of Electropalatography to Improve Speech Sound Production
The purpose of this proposed study is to examine the benefits of using electropalatography (EPG) during speech therapy with adult individuals who are either congenitally deaf or adventitiously deaf and use a cochlear implant.
- Trial name
- NCT04055987
- Testing
- Visual biofeedback, auditory feedback and models
- Sponsor
- Molloy College
Self-Help Devices, Eye-Gaze Technology
Applying Eye-Gaze Assistive Technology for Children and Youth With Complex Needs
The purpose of this research is to investigate the impacts of applying eye-gaze assistive technology (AT) in children and youth with severe disabilities and complex needs in Taiwan, where eye-gaze AT has not been researched for…
- Conditions
- Self-Help Devices, Eye-Gaze Technology, Severe Physical Disabilities, Communication Disorders
- Trial name
- NCT04377893
- Testing
- Eye gaze AT intervention
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Yu-Hsin Hsieh
Pain, Postoperative
mTLIP vs QIPB for Postoperative Analgesia After Lumbar Instrumentation Surgery
Lumbar instrumentation surgery is associated with severe postoperative pain due to extensive tissue dissection and prolonged muscle retraction during the procedure.
- Trial name
- NCT07370415
- Testing
- Modified Thoracolumbar Interfascial Plane Block (mTLIP), Quadro-Iliac Plane Block (QIPB):
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Pain, Acute, Analgesia
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
Using a retrospective review of records, we will conduct a multivariate analysis to examine the relationship between exposure to ketamine, as an analgesic agent in combat related trauma care, the use of additional opioid pain…
- Conditions
- Pain, Acute, Analgesia, Amputation, Traumatic, Post Traumatic Stress Disorder
- Trial name
- NCT04057989
- Testing
- ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Fibromyalgia
Membrane Lipid Replacement in Fibromyalgia
The purpose of this study is to determine the clinical effectiveness of an all-natural, patented wafer with active ingredients that are FDA approved as Generally Recognized as Safe (GRAS) Reference: US Federal Drug Administration…
- Trial name
- NCT03288389
- Testing
- NTFactor Lipids®
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Institute for Molecular Medicine
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