Clinical trials: Neurologic Findings
BIPOLAR DISORDER
Involvement of the Sodium Pump and Endogenous Digitalis-like Compounds in Bipolar Disorder
This study deals with the possible molecular mechanisms that underlie the etiology of bipolar disorders (BD). Previous studies have implicated Na+, K+-ATPase and endogenous digitalis-like compounds (DLC) in the depressive state…
- Trial name
- NA\K-MANIA (NCT01322113)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Parkinson, Tremor
Investigation of the Efficacy and Safety of IncobotulinumtoxinA (Xeomin) in Parkinson's Tremor: A Customized Approach
The scientific aim of this study is to investigate the efficacy and safety of incobotulinumtoxinA (Xeomin-Merz Pharmaceuticals) in the tremor of Parkinson"s disease.
- Trial name
- NCT02419313
- Testing
- incobotulinumtoxinA, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Hyperalgesia
A Study Of GSK189254 And Duloxetine In The Electrical Hyperalgesia Model Of Healthy Volunteers
GSK189254 is a highly potent histamine 3 (H3) receptor antagonist which has demonstrated efficacy in the reduction of mechanical hyperalgesia and allodynia in the chronic constriction injury pre-clinical model of neuropathic pain…
- Trial name
- NCT00387413
- Testing
- Duloxetine, GSK189254
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Somatic Symptom Disorder
Internet-based Emotional Awareness and Expression Therapy for Somatic Symptom Disorder - A Randomized Controlled Trial
The main purpose of this study is to conduct a Randomised Controlled Trial (RCT) where we evaluate an internet administrated version of Emotional Awareness and Expression Therapy (I-EAET) in the treatment of Somatic Symptom…
- Trial name
- MBS2 (NCT04751825)
- Testing
- I-EAET
- Where
- Sweden
- Volunteers
- 74 people
- Sponsor
- Karolinska Institutet
Acupuncture, Low Back Pain
Accessible Acupuncture for the Warrior With Acute Low Back Pain
The objective of this study is to determine if auricular acupuncture and/or the acupuncture point governor vessel 26 (GV26) with manual tonification is superior to conservative management (NSAIDs) at reducing acute low back pain…
- Trial name
- NCT04236908
- Testing
- NSAIDS, Battlefield Acupuncture, GV26 with manual tonification
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- David Moss
Hip Arthropathy, Postoperative Pain
Pericapsular Nerve Group Block for Total Hip Arthroplasty
Controlling pain after hip replacement surgery improves comfort and partient satisfaction. Pain after hip replacement has traditionally been managed using systemic pain medications including acetaminophen and non-steroidal…
- Trial name
- NCT04295408
- Testing
- Pericapsular nerve group block with saline solution, Pericapsular nerve group block with ropivacaine
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University Tunis El Manar
Pain, Postoperative
Comparison of the Efficacy of Erector Spina Plane Block and Thoracic Epidural Analgesia After Thoracotomy
In patients who undergoing lobectomy with thoracotomy incision, the effectiveness of erector spina plane block in post-operative analgesia management is at least as much as thoracic epidural anesthesia.
- Trial name
- ESPBTEAPAIN (NCT05402917)
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Mesut Aslan
Pain
Comparison of the Combined Serratus Anterior Plane Block Versus Superficial Serratus Anterior Plane Block
Breast cancer is the most common malignancy in women; surgery is a cornerstone of breast cancer treatment, and modified radical mastectomy is one of the standard treatments.
- Trial name
- NCT07394868
- Testing
- Combined serratus plan block, Superficial serratus plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Dystonia, Parkinson Disease
Lesioning Procedures for Movement Disorders
Dystonia is a rare syndrome with varying etiologies. Similarly, tremor conditions refractory to medical management and disabling that they need surgical interventions are rare in our setting.
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT06352268
- Testing
- Pallidal, subthalamic or thalamic lesioning
- Where
- India
- Volunteers
- 250 people
- Sponsor
- All India Institute of Medical Sciences
Health Services Misuse, Physician's Practice Patterns
Primary Care Clinician Commitments to Choosing Wisely®
This pragmatic trial examines the uptake and effects of primary care clinician commitments to follow 3 Choosing Wisely® recommendations.
- Conditions
- Health Services Misuse, Physician's Practice Patterns, Guideline Adherence, Unnecessary Procedures
- Trial name
- NCT02247050
- Testing
- Commitment invitation
- Where
- 6 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Michigan
Overactive Bladder (OAB), Botulinum Toxin Injection
Pretibial TENS for Pain and Anxiety During Intravesical OnabotulinumtoxinA Injection
Overactive bladder is a common condition that causes a frequent, urgent need to urinate and can significantly reduce quality of life.
- Conditions
- Overactive Bladder (OAB), Botulinum Toxin Injection, Procedural Pain Relief, Anxiety
- Trial name
- NCT07707791
- Testing
- Active Pretibial TENS
- Volunteers
- 68 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Laryngomalacia, Gastro Esophageal Reflux
Initiation of Acid Suppression Therapy Prospective Outcomes for Laryngomalacia
Laryngomalacia (LM) is the most common cause of stridor in infants. Symptoms of gastroesophageal reflux (GER) are often seen in the setting of LM; therefore, acid suppression therapy (AST) has been empirically used in the…
- Trial name
- NCT04614974
- Testing
- Famotidine, Speech Language Therapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Reema Padia
Ophthalmoplegia
Prevalence of a High-intensity Signal of the Oculomotor Nerve on T2 MRI Sequence in Patients With Ophthalmoplegia
Oculomotor nerve (third cranial nerve or III) palsy is a relatively frequent cause of consultation in ophthalmology. It may reveal a life-threatening pathology such as aneurysm rupture, pituitary apoplexy, and therefore need…
- Trial name
- HYPER-III (NCT03135574)
- Testing
- MRI T2 sequence of the oculomotor tract
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Postoperative Pain
Predictors of Postoperative Pain
The purpose of the study is to prove that pain scores generated from painful stimuli applied preoperatively may help identify the inter-individual variability in pain perception.
- Trial name
- NCT01449318
- Testing
- Thermal Sensory Analyzer (Senselab)
- Where
- 2 sites in Lebanon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Abdominal Pain
Abdominal Pain Management and Point-of-care Ultrasound in the Emergency Department
Background: Abdominal pain is one of the most common reasons for admission to the emergency department (ED). This study aimed to investigate the effect of point-of-care ultrasound (POCUS) performed during the initial evaluation…
- Trial name
- NCT05402774
- Testing
- point-of-care ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Neuropathic Pain, Cancer
Vulnerability and Risk of Neuropathic Pain in Cancer
Successive and repeated therapeutic interventions during cancer management - surgery, chemotherapy, radiotherapy - can all, to varying degrees, generate acute pain, central pain sensitization and chronic pain.
- Conditions
- Neuropathic Pain, Cancer, Predictive
- Trial name
- CANOPY (NCT06511674)
- Testing
- Cognitive-emotional and pain assessments
- Where
- 19 sites in France
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pain, Inflammation
Safety/Efficacy of Bromfenac Ophthalmic Solution for Ocular Inflammation and Pain Associated With Cataract Surgery
The primary objective of this study is to investigate the efficacy and safety of bromfenac ophthalmic solution for treatment of ocular inflammation and pain in subjects who undergo cataract extraction and intraocular lens…
- Trial name
- NCT00333918
- Testing
- bromfenac ophthalmic solution
- Where
- United States
- Volunteers
- 522 people
- Sponsor
- Bausch & Lomb Incorporated
Unstable Angina
Research on the Clinical Effect of Effective Prescription in Treating Unstable Angina.
This study evaluates the clinical efficacy of the famous prescription in the treatment of unstable angina pectoris. All of the patients will be divided into 4 arms according to their syndrome type.
- Trial name
- NCT03171597
- Testing
- Anti-Platelet Drugs, Lipid Regulating Drugs, Coronary Vasodilator
- Volunteers
- 240 people
- Sponsor
- Jun Li
Prostate Cancer Metastatic, Bone Metastases
Registry of Treatment Outcomes of Symptomatic Metastasized Castration Resistant Prostate Cancer Treated With Radium-223
Radium-223 is the 5th treatment for metastasized castration resistant prostate cancer with a proven overall survival benefit. The improved survival of Radium-223 over placebo was demonstrated in the ALSYMPCA trial, which included…
- Trial name
- ROTOR (NCT03223597)
- Testing
- Radium-223 dichloride
- Where
- 20 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- The Netherlands Cancer Institute
Narcolepsy Type 1
A Study to Evaluate the Efficacy, Safety and Tolerability of ALKS 2680 in Adults With Narcolepsy Type 1 (Brilliance NT1 - 304)
The purpose of this study is to measure decreases in daytime sleepiness, cataplexy (sudden loss of muscle tone), and disease symptoms in participants with NT1 when taking ALKS 2680 tablets compared with placebo tablets.
- Trial name
- NCT07540897
- Testing
- ALKS 2680 Dose 1, ALKS 2680 Dose 2
- Where
- 20 sites in United States, Belgium and 3 more
- Volunteers
- 150 people
- Sponsor
- Alkermes, Inc.
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