Clinical trials: Neurologic Findings
Pancreatitis, Chronic Pancreatitis
Internet-Delivered Pain Self-Management for Persons With Acute Recurrent and Chronic Pancreatitis Pain
Severe and disabling abdominal pain is common in individuals with chronic pancreatitis. Although pain is associated with reduced quality of life and high economic and societal costs, there are limited effective options for pain…
- Conditions
- Pancreatitis, Chronic Pancreatitis, Acute Recurrent Pancreatitis
- Trial name
- IMPACT-2 (NCT06386224)
- Testing
- Internet-delivered pain self-management (CBT Condition), Education Program
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Seattle Children's Hospital
Prader-Willi Syndrome
A 2-Part Study to Assess Efficacy, Safety and Tolerability of BMB-101 for the Treatment of Patients With Prader-Willi Syndrome.
The goal of this clinical trial is to evaluate the safety and effects of a new drug called BMB-101 in people with Prader-Willi Syndrome (PWS).
- Trial name
- NCT07266324
- Testing
- BMB-101
- Where
- 2 sites in Australia
- Volunteers
- 16 people
- Sponsor
- Bright Minds Biosciences Pty Ltd
Chronic Pain, Pain
Classifying and Predicting Long-term Pain and Function in Older Adults
This project will use novel methods to detect clinically meaningful subgroups of older adults based on long-term trajectories of bothersome pain and function.
- Trial name
- NCT04864223
- Where
- United States
- Volunteers
- 6,783 people, healthy volunteers welcome
- Sponsor
- University of Washington
Stroke
Acute Effects of Physiotherapy Interventions on Biceps Brachii Muscle Tissue Perfusion After Stroke
This study aimed to investigate the acute effects of proprioceptive neuromuscular facilitation (PNF), the Bobath concept, and virtual reality (VR)-based interventions on biceps brachii tissue perfusion in individuals with chronic…
- Trial name
- NCT07853859
- Testing
- Proprioceptive Neuromuscular Facilitation (PNF), Bobath Concept, Virtual Reality (VR)-Based Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Izmir Bakircay University
Pain, Postoperative
TOTEM: Trial of TAP Block Effective Medications
Our goal is to determine if liposomal bupivacaine compared to standard bupivacaine results in increased pain control and decreased narcotic pain medication use when used in TAP blocks prior to laparoscopic hysterectomies for…
- Trial name
- TOTEM (NCT04382859)
- Testing
- Transversus abdominis plane (TAP) block with liposomal bupivacaine
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Western Michigan University School of Medicine
Knee Arthropathy
Persistent Post Surgical Pain After Total Knee Arthroplasty
Patients undergone total knee replacement are randomized to receive a "fast track" regional anesthesia protocol or a "traditional" regional anesthesia continuous infusion by both a femoral and sciatic catheter to assess if this…
- Trial name
- NCT06182059
- Testing
- continuous peripheral nerve block
- Where
- Italy
- Volunteers
- 436 people
- Sponsor
- Policlinico di Monza SpA
Local Analgesia Via Infiltration, Wound Heal
Comparison of Postoperative Effects of Articaine and Lidocaine in Mucogingival Surgery
The aim of this study is to compare and evaluate the effects of using lidocaine 2% (with adrenaline) and articaine 4% (with adrenaline) in free gingival graft (FGG) surgery on postoperative wound healing, changes in blood flow in…
- Conditions
- Local Analgesia Via Infiltration, Wound Heal, Pain, Postoperative, Hemorrhage
- Trial name
- NCT07145879
- Testing
- Lidocaine hydrochloride 2% with epinephrine 1:100 000, Articaine 4% with epinephrine 1:100,000, Free gingival graft (FGG)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Osteoarthritis, Unicompartmental Knee Arthroplasty
Post-op Prednisone and Glucose Monitoring in TKA
This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels…
- Conditions
- Osteoarthritis, Unicompartmental Knee Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT07630896
- Testing
- Prednisone, Continuous Glucose Monitor, InkWell Health Tattoos
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Columbia University
Neurogenic Bladder, Bladder Dysfunction
Vascularized Composite Bladder Allograft Transplantation
This phase 0 trial tests the feasibility, functionality, and sustainability of vascularized composite bladder allograft transplantation in treating patients with terminal bladder pathology.
- Conditions
- Neurogenic Bladder, Bladder Dysfunction, Immunosuppression
- Trial name
- NCT05462561
- Testing
- Quality-of-Life Assessment, Robotic Vascularized Composite Bladder Allograft Transplantation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Southern California
Sleep Disorder
Evning Exposure to Computer Screen Disrupts Sleep, Attention and Biological Rhythms
Light exposure is on the rise in recent years. In large part because of unintentional illumination from screens that emit light directly into the eyes.
- Trial name
- NCT02957383
- Testing
- Wavelength, Intensity
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Acute Pain, Respiration
Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers
The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model.
- Conditions
- Acute Pain, Respiration, Sedation
- Trial name
- Remiclon (NCT00730054)
- Testing
- Remifentanil+clonidine
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Opioid-use Disorder, Chronic Pain
Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment
The proposed IMPOWR Research Center at Montefiore-Einstein (IMPOWR-ME) will create a multidisciplinary and synergistic program of research to test multimodal treatments that address both chronic pain and opioid use disorder.
- Trial name
- NCT05039554
- Testing
- Acceptance and commitment therapy, Valera Smartphone Application, Treatment as Usual
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Albert Einstein College of Medicine
Facial Pain, Headache
Effects of Photobiomodulation With Superpulsed Laser and Dual Wavelengths in Children and Adolescents
This randomized clinical trial evaluates the effects of photobiomodulation with a superpulsed diode laser (810 + 980 nm) on orofacial pain and tension-type headache in children and adolescents.
- Trial name
- NCT07031505
- Testing
- Active Photobiomodulation
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
Irreversible Pulpitis
Ketorolac Premedication for Anesthetic Efficiency of IANB & Postendodontic Pain in Teeth With Irreversible Pulpitis
The aim of this study to assess effect of ketorolac premedication on the effectiveness of the inferior alveolar nerve block, pretreatment and postoperative pain in patients with symptomatic irreversible pulpitis.
- Trial name
- NCT02940405
- Testing
- Ketorolac Tromethamine
- Volunteers
- 38 people
- Sponsor
- Cairo University
Sacroiliac Joint Dysfunction
Effects of Pelvic Floor Exercises and Muscle Energy Techniques on Pain and Disability in Sacroiliac Joint Dysfunction
This clinical trial aims to evaluate whether combining pelvic floor exercises with muscle energy techniques provides greater improvement in pain and functional disability in adults with sacroiliac joint dysfunction compared to…
- Trial name
- NCT07275294
- Testing
- Muscle Energy Techniques with Hot pack and Transcutaneous Electrical Nerve Stimulation, Muscle Energy Techniques with Hot pack, Transcutaneous Electrical Nerve Stimulation and Pelvic floor Exercises
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Parkinson Disease
Emotional Prosody Treatment in Parkinson's
This study investigates a treatment protocol which holds the potential to significantly improve communication and quality of life for individuals affected by Parkinson's disease (PD).
- Trial name
- NCT01956266
- Testing
- Emotional prosodic treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Amputation Stumps, Pain
Enriched Autologous Fat Grafting for Treating Pain at Amputation Sites
The objective of this pilot study is to assess the efficacy of minimally invasive autologous fat transfers at the amputation sites and the modulation of pain at the respective sites.
- Trial name
- AMP-5 (NCT01645722)
- Testing
- Procedure/Surgery: Enriched Fat grafting
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Irritable Bowel Syndrome
Experience Sampling Method for Symptom Assessment in Irritable Bowel Syndrome
Reliable patient reported outcome measures (PROM's) for symptom assessment in irritable bowel syndrome are essential in order to investigate natural disease course and potential treatment options aimed at symptom improvement…
- Trial name
- NCT02880722
- Where
- Netherlands
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Acquired Brain Injury
Action Observation Theraphy in Severe Acquired Brain Injury.
Action Observation Therapy (AOT) is a rehabilitation technique, used for several years, aimed at the recovery of motor function in patients with neurological and orthopedic conditions.
- Trial name
- NCT05747222
- Testing
- Action Observation Tharapy, Conventional Therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Foot Fracture, Pain, Acute
Tramadol Simultaneously With Sciatic Nerve Block for Calcaneus Fracture Osteosynthesis
Comparison of duration of efficient analgesia after painful surgical repair od foot fractures between groups treated with sciatic nerve block alone and sciatic nerve block simultaneously with i.m. tramadol
- Trial name
- TramIsch (NCT03477851)
- Testing
- Tramadol Hydrochloride
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Warsaw
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