Clinical trials: Neurologic Symptoms
Stroke, Acute, Cerebral Infarction
Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3
This is a study to evaluate the hypothesis that FDA cleared thrombectomy devices plus medical management leads to superior clinical outcomes in acute ischemic stroke patients at 90 days when compared to medical management alone…
- Trial name
- DEFUSE 3 (NCT02586415)
- Testing
- Endovascular Thrombectomy, Trevo Retriever, Solitaire™ FR Revascularization Device
- Where
- 40 sites in United States
- Volunteers
- 182 people
- Sponsor
- Gregory W Albers
Parkinson Disease
The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity.
- Trial name
- NCT04472325
- Where
- Taiwan
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Vertigo
Validation of a Simultaneous Ocular/Cervical VEMP With Mastoid Vibration by B250
A Validation study in which the standard separate cVEMP and oVEMP will be compared with a new protocol in which the cVEMP and oVEMP can be recorded simultaneously in response to a mastoid vibration by bone transducer B250
- Trial name
- BCVEMP By B250 (NCT05889676)
- Testing
- VEMP by bone conduction
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Stockholm
Narcolepsy Type 1, Hypersomnia
Efficacy of the Dreem 3S Ambulatory Sleep Monitoring Device for the Evaluation of Narcolepsy
This study intends to examine the utility of a home-use EEG-based sleep monitor for the diagnosis and evaluation of disorders of excessive sleepiness, specifically the neurological disorder Narcolepsy Type 1.
- Conditions
- Narcolepsy Type 1, Hypersomnia, Sleep Disorder
- Trial name
- NCT06531876
- Testing
- Dreem 3S recording
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- Beacon Biosignals
Delirium
Rivastigmine in the Management of Delirium
The aim of this study is to evaluate the efficacy of an anticholinesterase treatment in patients aged 75 and over, hospitalized with delirium.
- Trial name
- confuriv (NCT01487317)
- Testing
- Rivastigmine transdermal patch
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mild Cognitive Impairment, Obesity
Caloric Restriction in Obese Patients With Mild Cognitive Impairment: Effects on Adiposity, Comorbidity and Cognition
Obesity has been associated with cognitive impairments, lower blood flow, metabolic activity and brain volume. Obesity in adulthood is a risk factor for Alzheimer's disease in the elderly.
- Trial name
- NCT01286389
- Testing
- medical care, caloric restriction
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Sarcopenia
Omega-3 Supplementation in Cervix Cancer Patients Undergoing Chemoradiotherapy
Cancer cachexia is a complex metabolic process affecting up to 80% of patients suffering from an advanced-stage cancer. Moreover, 20 to 40% of all cancer deaths are caused directly by cachexia.
- Trial name
- NCT02779868
- Testing
- Omega-3, Olive oil
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brazilian National Cancer Institute
Rehabilitation, Postoperative Pain
Effect of Dezocine Combined With Sufentanil on the Quality of Postoperative Recovery and Analgesic Effect in Patients Undergoing Thoracic Surgery
The goal of this clinical trial is to evaluate the effect of dezocine combined with sufentanil on postoperative recovery quality and analgesic effect in patients undergoing thoracic surgery.
- Trial name
- NCT06439368
- Testing
- Dezocine
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Yangtze River Pharmaceutical Group Co., Ltd.
Hemianopia, Brain Tumor
Visual Rehabilitation in Children With Homonymous Hemianopia: a Pilot Study on Virtual-reality Stimulation
There are currently no visual rehabilitation strategies for children presenting visual field defects consecutive to a brain tumor or its treatment.
- Conditions
- Hemianopia, Brain Tumor, Children, Only
- Trial name
- HH-IVR (NCT05065268)
- Testing
- Immersive Virtual-Reality Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Branch Retinal Vein Occlusion
Efficacy and Safety of Ranibizumab With or Without Laser in Comparison to Laser in Branch Retinal Vein Occlusion
This study will generate comparative data for 0.5-mg ranibizumab using PRN dosing administered with or without adjunctive laser treatment versus laser photocoagulation (the current standard of care) up to Month 6 in patients with…
- Trial name
- BRIGHTER (NCT01599650)
- Testing
- Ranibizumab, Laser
- Where
- 82 sites in Australia, Canada and 15 more
- Volunteers
- 455 people
- Sponsor
- Novartis Pharmaceuticals
Procedural Pain, Procedural Anxiety
Efficacy of VR and Buzzy on Pain and Anxiety
The study was designed as a randomized controlled experimental research with the purpose of determining the effect of distraction by using external cold and vibration-Buzzy and VR on reducing procedural pain and anxiety in…
- Conditions
- Procedural Pain, Procedural Anxiety, Pain, Children, Only
- Trial name
- NCT05179291
- Testing
- Buzzy Group, Virtual Realitiy-VR Group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Total Knee Arthroplasty
Adductor-Canal-Blockade Versus the Femoral Nerve Block Effect on Muscle Strength, Pain and Mobilization After Total Knee Replacement
The aim of this study is to investigate the efficacy of the Adductor-Canal-Blockade versus the Femoral Nerve Block on muscle strength, pain and mobilization after total knee arthroplasty.
- Trial name
- NCT01470391
- Testing
- Adductor-Canal-Blockade, Femoral Nerve Block
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Attention Deficit Disorder With Hyperactivity
Sleepiness and Driving Performances in Adults With Attention-Deficit/ Hyperactivity Disorder (ADHD)
The Attention Deficit/ Hyperactivity Disorder (ADHD) is a developmental disorder which affects 3 to 5 % of school age children. This disorder persists in the adulthood for 60 % of subjects.
- Trial name
- SOMTDA/H (NCT01160874)
- Testing
- Polysomnography, Maintenance Wakefulness Test, Neuropsychological evaluation
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Chronic Pain, Insomnia
Digital CBT-I for Patients With Chronic Pain and Insomnia
Chronic pain constitutes an increasing health and social burden. More than 50% of patients with chronic pain report insomnia, and patients with comorbid insomnia often report stronger and widespread pain, compared to those who…
- Trial name
- Back2Sleep (NCT06361914)
- Testing
- Digital CBT-I, Digital Sleep hygiene education
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
Communication Disabilities
Implementation of Communication Disability Collection and Accommodations in Primary Care Settings
This multi-methods-multi-site study aims to adapt and evaluate the effects of an implementation support package of strategies to assist primary care clinics in documenting patients' communication disability (CD) and accommodation…
- Trial name
- DECA (NCT07656584)
- Testing
- Implementation Support Package
- Where
- 5 sites in United States
- Volunteers
- 126,870 people
- Sponsor
- NYU Langone Health
Arrhythmia, Palpitations
7-Day MEMO Patch Monitoring for Arrhythmia Detection in Patients With Palpitations
"This exploratory prospective clinical study aims to evaluate the diagnostic yield of a 7-day adhesive electrocardiographic (ECG) monitoring device (MEMO Patch) in detecting cardiac arrhythmias in patients presenting with…
- Conditions
- Arrhythmia, Palpitations, Syncope
- Trial name
- NCT07728552
- Testing
- MEMO Patch, 24-Hour Holter Monitor
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- HUINNO Co., Ltd
Contraception, Pain
Efficacy of Intrauterine Lidocaine and Naproxen for Pain Control With Intrauterine Device Insertion
To compare the efficacy of intrauterine lidocaine and oral naproxen sodium on discomfort and pain of patients undergoing intrauterine device insertion.
- Trial name
- NCT02769247
- Testing
- Naproxen, Lidocaine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Pain
A Clinical Study of the Combination of SHR8554 Injection and SHR0410 Injection for the Treatment of Pain After Abdominal Surgery.
The primary objective is to evaluate the analgesic efficacy of the combination of SHR8554 injection and SHR0410 injection compared with SHR8554 injection in patients with acute postoperative pain following abdominal surgery
- Trial name
- NCT05470049
- Testing
- SHR8554 Injection and SHR0410 Injection
- Volunteers
- 108 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Noise Exposure, Hearing Loss, Noise-Induced
A Multilevel Intervention to Prevent Noise Exposure in Farmworkers
This study will test a program to reduce noise exposure and prevent hearing loss among farmworkers. Farmworkers are often exposed to high levels of noise from machinery, which can lead to hearing loss over time.
- Conditions
- Noise Exposure, Hearing Loss, Noise-Induced, Occupational Exposure
- Trial name
- POP (NCT07554378)
- Testing
- Multilevel Hearing Protection Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Epilepsy, Focal Cortical Dysplasia
Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery
Refractory epilepsy, meaning epilepsy that no longer responds to medication, is a common neurosurgical indication in children. In such cases, surgery is the treatment of choice.
- Conditions
- Epilepsy, Focal Cortical Dysplasia, Tuberous Sclerosis, Hemimegalencephaly
- Trial name
- NCT04344626
- Testing
- Intra-operative brain tonometry
- Where
- 2 sites in United States, Canada
- Sponsor
- University of California, Los Angeles
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