Clinical trials: Neurologic Symptoms
Injection Site Pain
The Effect of the Cold Needle Technique on Pain and Patient Satisfaction Levels During Intramuscular Injection Administered to the Ventrogluteal Site
This randomized controlled trial aims to evaluate the effect of the cold needle technique on pain and patient satisfaction during intramuscular injections administered to the ventrogluteal site.
- Trial name
- NCT07860099
- Testing
- Cold Needle Technique, Standard Intramuscular Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Bezmialem Vakif University
Angina Pectoris, Left Ventricular Wall Motion Abnormalities
Intraprocedural Determination of Myocardial Vitality Using 2 Different Imaging Methods
The investigators will compare myocard vitality diagnostics using 2D-Strain echography and MRI.
- Trial name
- NCT01934699
- Testing
- Cardiac ultrasound, MRI scanner
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- RWTH Aachen University
Heterotopic Ossification
Early Ultrasound Screening of Heterotopic Ossification After Severe Neurological Trauma
Prospective, bi-centric diagnostic, performance study on a new diagnostic procedure with ultrasounds against a reference diagnostic procedure.
- Trial name
- POHER II (NCT04934332)
- Testing
- Ultrasound, CT scan, Clinical examination
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea, Heart Rhythm Disorder
Obstructive Sleep Apnea Destabilizes Myocardial Repolarization Homogeneity
Literature shows that patients with obesity and Obstructive Sleep Apnea (OSA), both occurring independently, are more likely to develop cardiovascular diseases and sudden cardiac death (SCD).
- Conditions
- Obstructive Sleep Apnea, Heart Rhythm Disorder, Obesity, Abdominal
- Trial name
- NCT04621032
- Testing
- Polygraphy monitoring, laboratory tests
- Volunteers
- 187 people
- Sponsor
- Nowodworskie Centrum Medyczne
Atherosclerosis, Coronary Artery Disease
ARISE - Aggressive Reduction of Inflammation Stops Events
To assess the safety and efficacy of AGI-1067, as compared to placebo, in the treatment of vascular inflammation and atherosclerosis by assessing the reduction in cardiovascular events.
- Conditions
- Atherosclerosis, Coronary Artery Disease, Myocardial Infarction, Unstable Angina
- Trial name
- NCT00066898
- Testing
- AGI-1067
- Where
- 219 sites in United States, Canada and 2 more
- Volunteers
- 6,000 people
- Sponsor
- AtheroGenics
Acute Pain, Chronic Postsurgical Pain
The Influence of Different Anesthesia on Acute and Chronic Postsurgical Pain After Thoracic Surgery
This study would compare acute and chronic postsurgical pain in patients underwent thoracic surgery with different anesthesia and analgesia methods, and explore the influencing factors.
- Trial name
- NCT03847363
- Testing
- epidural anesthesia, nerve block
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai Zhongshan Hospital
Opioid Dependence
DE-eSCALation of Opioids Post-surgical dischargE
The Descale Study aims to: 1. Look at the prescribing trends of opioids and the scale of long-term use following surgery within East Kent (United Kingdom) 2.
- Trial name
- DESCALE (NCT06396663)
- Testing
- Rapid Opioid de-escalation, Gradual Opioid de-escalation, Continuation of opioids
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Kent
Female Breast Cancer, Post Operative Pain
Pulsed Electromagnetic Fields for Analgesia Post Mastectomy
Study aim is to test AlgoCare, a device that uses the technology PEMF (Pulsed ElectroMagnetic Fields) for the treatment of postoperative pain in oncological breast surgery, in order to demonstrate that the use of Algocare in the…
- Trial name
- Algocare (NCT06331793)
- Testing
- Active AlgoCare, Non-active AlgoCare
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- European Institute of Oncology
Multiple Sclerosis, Relapsing-Remitting
A Study of Rebif® in Subjects With Relapsing Multiple Sclerosis
This is an open-label, multi-center, 12-week, randomized, controlled, parallel group, Phase 4 study to assess whether the morning administration of interferon beta 1a (Rebif®) leads to a lower severity of flu-like symptoms (FLS)…
- Trial name
- RELIEF (NCT02064816)
- Testing
- Rebif®
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Alzheimer's Disease, Hippocampus
Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment
This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease.
- Conditions
- Alzheimer's Disease, Hippocampus, Brain Atrophy, Magnetic Resonance Imaging
- Trial name
- NCT06965816
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Denis
Post Operative Pain
Comparative Study Between Dexmedetomidine and Fentanyl as Adjuvants to Bupivacaine
Combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post…
- Trial name
- NCT06864416
- Testing
- dexmedetomidine as adjuvant to bupivacaine, Fentanyl as adjuvant to bupivacaine
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Depressive Symptoms, Clinical Depression
Improving Mood in Assisted Living Settings
Late-life depression levels are escalating, and include 24% of all tenants of Assisted Living (AL) settings. A promising, novel intervention is a computerized visual speed of processing training program known as Road Tour.
- Trial name
- NCT01763216
- Testing
- Road Tour, Boatload of Crosswords
- Where
- 32 sites in United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Marianne Smith
Headache, Intranasal Ketamine
"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
This is a randomized, single-blind, placebo controlled trial to evaluate the efficacy of sub-dissociative dose ketamine versus standard care therapy for acute headache management of in patients presenting to the emergency…
- Trial name
- THINK (NCT03081416)
- Testing
- Ketamine, Normal saline, Metoclopramide
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Pain
Caring for Babies: A Study of Ontario Maternal-Newborn Hospitals on the Implementation of Parent-targeted Education
Newborn infants have blood work procedures for newborn screening and bilirubin testing in their first days of life that cause pain, distress and physiological changes.
- Trial name
- ONesiE (NCT03099252)
- Testing
- Parent-targeted BSweet2Babies video
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Headache, Aneurysm
Headache After Coil Embolization for Unruptured Intracranial Aneurysms
Perform a prospective cohort study to compare the incidence and severity of headache between non-stent assisted coiling and stent assisted coiling of unruptured intracranial aneurysms.
- Conditions
- Headache, Aneurysm, Endovascular Procedures
- Trial name
- NCT03359252
- Testing
- non-stent assisted coiling, stent assisted coiling
- Where
- South Korea
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cerebral Palsy
A Gamified Breathing and Postural Awareness Education Model for Children With Cerebral Palsy
This project aims to develop an accessible, learning-oriented model based on gamified breathing and posture training that emphasizes active participation for children with cerebral palsy (CP), their families, and educators.
- Trial name
- NEFES-CP (NCT07681947)
- Testing
- N.E.F.E.S.-CP Education Model
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yeditepe University
Phantom Limb, Leg Amputation
Leg Amputation and Continuous Sciatic Nerve Block
Analgesia following leg amputation is based on morphine administration. For elderly patients of ASA physical status 2 or 3, morphine sparing is possible when perinervous block techniques are used.
- Trial name
- CAPDAF (NCT00427947)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Bordeaux
Diet Habit, Diet Modification
Interaction of Salivary Proteins and Polyphenols
Participants will be chosen through an initial sensory test to find high and low-perceivers of astringency. Selected participants will drink a chocolate milk or milk substitute beverage for one week each with washout weeks in…
- Conditions
- Diet Habit, Diet Modification, Taste, Altered, Saliva Altered
- Trial name
- NCT03501238
- Testing
- Chocolate Milk, Chocolate milk substitute, Chocolate milk substitute with gelatin
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Purdue University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- CogCheck-Valid (NCT03360838)
- Testing
- CogCheck
- Where
- Switzerland
- Volunteers
- 475 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Pain, Chronic Pain, Widespread
Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of Pain
This is a clinical trial that intend to determine the effects of S-ketamine on event-related potentials associated with semantic affective pain-processing
- Conditions
- Acute Pain, Chronic Pain, Widespread, Schizophrenia
- Trial name
- NCT03915938
- Testing
- Ketamine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
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