Clinical trials: Neurological; Disorder, Nervous System
Dementia, Paratonia
Safety and Effectiveness of Botulinum Toxin in Elderly Patients With Dementia and Muscle Stiffness
Aim of the study is to perform a pilot study to assess the impact of Botulinum toxin on muscle tone, and caregiver burden in individuals who are cognitively impaired and who are fully dependent.
- Trial name
- NCT02212119
- Testing
- Botulinum Toxin, Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Assistive Technology Clinic, Canada
Hypoxic-Ischemic Encephalopathy, Pain
Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)
Management of neonatal pain and sedation often includes opioid therapy. A growing body of evidence suggests long-term harm associated with neonatal opioid exposure.
- Trial name
- DICE (NCT04772222)
- Testing
- Dexmedetomidine Hydrochloride, Morphine Sulfate
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Pain Control in Heel Prick Procedure
Comparing 0.2 ml and 0.5 ml Oral 24% Sucrose Solution for Pain Relief During Heel Prick in Neonates With Historical Controls
The goal of this clinical trial is to determine whether a lower dose of oral 24% sucrose solution provides pain relief that is non-inferior to a higher dose during routine heel-prick procedures in term neonates.
- Trial name
- Sucrose (NCT07784322)
- Testing
- 24% oral sucrose
- Where
- Hong Kong
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kwong Wah Hospital
Lifestyle Factors, Overweight and Obesity
Effect of Sleep Extension on Ceramides in People With Overweight and Obesity
The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity.
- Conditions
- Lifestyle Factors, Overweight and Obesity, Insulin Sensitivity, Eating Habit
- Trial name
- NCT06180837
- Testing
- Sleep Extension Intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Utah
Analgesia
A Study Evaluating the Efficacy and Safety of HSK21542 Injection for Analgesia in Subjects Undergoing Colonoscopy
This is a multi-center, randomized, two-stage, phase II clinical study .The main objective is to evaluate the safety and tolerability of HSK21542 injection for analgesia in patients undergoing colonoscopy, and, combining the…
- Trial name
- NCT04470128
- Testing
- Stage I: HSK21542 0.5 μg/kg, Stage I: HSK21542 1 μg/kg, HSK21542 0.5 μg/kg
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
PARKINSON DISEASE (Disorder), Deep Brain Stimulation
Anesthesia and Postoperative Delirium in Parkinson DBS
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a rising incidence due to global aging. Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is a core therapeutic modality for motor…
- Conditions
- PARKINSON DISEASE (Disorder), Deep Brain Stimulation, Postoperative Delirium
- Trial name
- POD-DBS-PD (NCT07792265)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Migraine Disorders
Effect of Metoclopramide Versus Sumatriptan for Emergency Department Treatment of Migraine Headache
The purpose of this study is to determine which drug makes lower migraine headache
- Trial name
- NCT01791400
- Testing
- metoclopramide, injection,20mg, one time, Sumatriptan, injection, 6 mg, one time
- Where
- Iran
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Chronic Neck Pain
Diaphragmatic Breathing and Electroacupuncture for Chronic Neck Pain
Chronic non specific neck pain is a prevalent musculoskeletal disorder with significant impact on pain, forward head posture, and neck disability.
- Trial name
- NCT07684092
- Testing
- physiotherapy care, diaphragmatic breathing, and electroacupuncture, physiotherapy care, simple focused breathing exercises, and electroacupuncture
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- University of Lahore
Chronic Troublesome Sialorrhea, Cerebral Palsy
Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability
The objective of this study is to investigate the efficacy and safety of NT 201 compared with placebo for the treatment of chronic troublesome sialorrhea associated with neurological disorders (e.g.
- Conditions
- Chronic Troublesome Sialorrhea, Cerebral Palsy, Stroke, Traumatic Brain Injury
- Trial name
- SIPEXI (NCT02270736)
- Testing
- NT 201
- Where
- 31 sites in Georgia, Hungary and 4 more
- Volunteers
- 256 people
- Sponsor
- Merz Pharmaceuticals GmbH
Trauma, Neurologic Deficits
CT Change Management in Trauma Patients
In high-volume trauma centers, multi-slice CT scanners have become the routine imaging modality for screening trauma patients due to their speed and accuracy.
- Trial name
- NCT05138536
- Testing
- Pan-Computer Tomography
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Methodist Health System
Central Nervous System Disorder, Spine Disease
Neurological Surgery & Affiliated Services De-Identified Clinical Outcomes Database
The collection of data from the myriad of services described is significantly impacted by NIH guidelines defining medical research involving humans as well as the recent implementation of HIPAA constraints which further…
- Conditions
- Central Nervous System Disorder, Spine Disease, Peripheral Nerve Disorder
- Trial name
- MDAnalyze (NCT00593411)
- Where
- United States
- Volunteers
- 732 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Vertigo, Dizziness
Translation of Dizziness Handicap Inventory Scale Into Local Languages of Pakistan
The aim of the present study is to translate the Dizziness Handicap Inventory Scale into Urdu, Pashto, Punjabi, Sindhi and Balochi languages.
- Trial name
- NCT04849078
- Where
- Pakistan
- Volunteers
- 1,000 people
- Sponsor
- Riphah International University
Pain
The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery
The analgesic effect of dexamethasone is not well described, but studies have shown that dexamethasone can be a safe part of a multimodal analgesic strategy after surgery.
- Trial name
- NCT01953978
- Testing
- Dexamethasone, Morphine, Zofran
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sarcopenia
The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults
Aging is associated with a decline in muscle mass, strength, and physical function, leading to sarcopenia and frailty. This deterioration of muscle and physical capabilities impacts an individual's functional independence and…
- Trial name
- NCT06157385
- Testing
- Culinary Medicine, Control
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Parkinson Disease, Parkinsonian Syndrome
A Study of the Sense of Smell in Relatives of Parkinson's Disease Patients
In this study, individuals complete and return a mail survey, specifically a 40 item scratch and sniff smell test.
- Trial name
- NCT00096876
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Grip, Muscle Disorder
Investigation of Grip Strength, Pain and Anxiety Levels in Dentists
The aim of the study is to evaluate the relationship between professional experience and grip strength, pain threshold and anxiety level in dentists.
- Conditions
- Grip, Muscle Disorder, Pain, Chronic, Anxiety
- Trial name
- NCT06721117
- Testing
- Grip strength assessment, Forearm muscle strength assessment, Pain threshold assessment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Persistent Lower Back Pain, Sleep Disturbance
What Are Persistent Lower Back Pain Patients' Views of Sleep Health Within an Outpatient Musculoskeletal Physiotherapy Setting?
The goal of this qualitative is to understand the views and opinions of patients with persistent lower back pain patients who are awaiting physiotherapy treatment with regards sleep their sleep health.
- Conditions
- Persistent Lower Back Pain, Sleep Disturbance, Lower Back Pain, Chronic Low-back Pain
- Trial name
- NCT06094517
- Testing
- Interview
- Volunteers
- 10 people
- Sponsor
- Sheffield Hallam University
Hot Flashes, Memory Loss
Phytoserms for Menopause Symptoms and Age-Associated Memory Decline
The purpose of this study is to evaluate the safety and efficacy of a soy based dietary supplement (phytoSERM) for hot flashes and age associated memory loss.
- Trial name
- phytoSERM (NCT01723917)
- Testing
- PhytoSERM tablet
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Southern California
Age-related Hearing Loss, Hearing Loss, Sensorineural
Comparing the Efficacy of Domestic Versus Imported Hearing Aids in ARHL
This study compares the hearing improvement effects of domestic hearing aids and imported hearing aids in 80 patients with moderate to severe and severe age-related hearing loss.
- Trial name
- NCT06882889
- Testing
- Domestic hearing aids, Imported hearing aids
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Covid19, Coma
Prognostication of Recovery in Early Disorders of Consciousness After COVID-19
The primary aim of this research proposal is to use multimodal metrics (e.g., clinical data and advanced neuroimaging) in the early (i.e., acute hospitalization) phase of recovery from COVID-19-related disorders of consciousness…
- Conditions
- Covid19, Coma, Consciousness Disorder
- Trial name
- PREDICT-COVID (NCT04476589)
- Testing
- Functional MRI
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.