Clinical trials: Neurological; Disorder, Nervous System
Post-Traumatic Headache
Behavior Therapy vs Education for Persistent Headache After Mild TBI
This study will test a new treatment, called Headache reprocessing, for persistent post-traumatic headache. The new treatment will be compared to a headache education intervention.
- Trial name
- NCT07229391
- Testing
- Headache reprocessing, Headache education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Alzheimer's Disease, Mild Cognitive Impairment
Alzheimer's Disease Core Center
The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Memory Disorders
- Trial name
- ADCC (NCT01421420)
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Migraine, Headache
Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine.
The purpose of this study is to determine whether a fixed-dose combination of naratriptan 2,5 mg + naproxen 500 mg is effective and safe compared each monotherapy for the acute treatment of migraine.
- Trial name
- Copérnico (NCT01726920)
- Testing
- naratriptan + naproxen, naratriptan, naproxen
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Sleep Deprivation
Combined Effects of Acute Sleep Restriction and Moderate Acceleration (+Gz) on Physiological and Behavioral Responses to High Mental Workload
Fighter pilots have to perform tasks requiring high mental workload during moderate-intensity acceleration phases (2 to 3G) that can last several minutes.
- Trial name
- CogPhyAero (NCT06017882)
- Testing
- Partial sleep deprivation
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Delirium
Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients
The purpose of this study is to assess the efficacy of dexmedetomidine versus propofol for prolonged sedation in trauma and surgical patients.
- Trial name
- NCT02548923
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Progressive Supranuclear Palsy
A Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Subjects With Progressive Supranuclear Palsy (PSP)
The purpose of this study was to assess efficacy, safety, tolerability, and pharmacokinetics of ABBV-8E12 in participants with progressive supranuclear palsy (PSP).
- Trial name
- NCT02985879
- Testing
- ABBV-8E12
- Where
- 66 sites in United States, Australia and 6 more
- Volunteers
- 378 people
- Sponsor
- AbbVie
Emergence Delirium, Perioperative Neurocognitive Disorder
Quantitative Neurofeedback Techniques for Treating Perioperative Cognitive Disorders in Elderly Patients
The goal of this clinical trial is to learn if quantitative measurement of brain and neurofeedback intervention techniques works to prevent perioperative neurocognitive deficits in elderly oncology patients who are to undergo…
- Trial name
- NCT06752148
- Testing
- neurofeedback intervention training game
- Volunteers
- 390 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Postoperative Pain, Chronic Pain
Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE).
To assess the effects of prolonged preoperative gabapentin treatment (10 days) on chronic pain after thoracotomy.
- Trial name
- GABATHOMIE (NCT03158376)
- Testing
- Gabapentin
- Where
- France
- Volunteers
- 201 people
- Sponsor
- University Hospital, Lille
Developmental, Behavioral and Mental Health, Adhd
Using Telehealth to Deliver Mental Health Services in Primary Care Settings for Children in Underserved Areas
In partnership with a multi-site, Los Angeles-area community clinic consortium, North East Valley Health Corporation (NEVHC), the investigators will use telehealth to integrate pediatric developmental, behavioral and mental…
- Conditions
- Developmental, Behavioral and Mental Health, Adhd, Depression, Anxiety
- Trial name
- NCT02396576
- Testing
- Telehealth Intervention
- Where
- 6 sites in United States
- Volunteers
- 359 people
- Sponsor
- University of California, Los Angeles
Obstructive Sleep Apnea (OSA), Down Syndrome
Endotype DIrected Treatment for OSA in Down Syndrome
Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing while asleep.
- Trial name
- EDIT OSA (NCT07280468)
- Testing
- ato-oxy, Oxygen
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Down Syndrome, Cognitive Dysfunction
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
The purpose of this study is to determine the efficacy and safety of donepezil hydrochloride (Aricept) in the treatment of cognitive dysfunction shown by children with Down syndrome, aged 6 to 10 years.
- Trial name
- NCT00754013
- Testing
- Aricept (Donepezil hydrochloride)
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Eisai Inc.
Parkinson Disease, Pain
Transcranial Alternating Current for Oscillopathies
The need for non-invasive, non-pharmacological and cost-effective therapeutic options has revived the use of transcranial current stimulation, either direct (tDCS) or alternating (tACS), in a wide range of pathologies and…
- Trial name
- tACS_EEG (NCT03221413)
- Testing
- transcranial alternating current stimulation (tACS)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Padova
Rett Syndrome
Pharmacological Treatment of Rett Syndrome With Statins
This is a phase 2 , open label, dose escalating study of Lovastatin in Rett syndrome.
- Trial name
- Statins (NCT02563860)
- Testing
- Lovastatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Montefiore Medical Center
Analgesia
Development of a New Method for Analgesia
Aim: To examine a new method to perform local anesthesia in order to diminish the inconvenience by the procedure in patients before performing intubation or oesophagogastroduodenoscopy.
- Trial name
- NCT00791024
- Testing
- CRC-Pharma 001, lidocaine suspension
- Where
- Denmark
- Volunteers
- 126 people
- Sponsor
- Ove Andersen
Strabismus
Mobile Medical Application for Cost-effective Strabismus Screening
Develop and evaluate a new smartphone based app to screen for and measure eye misalignment (strabismus). The investigators will validate the app against simulated strabismus of known magnitude and common clinical tests.
- Trial name
- NCT03450980
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Osteopenia, Osteoporosis
Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis
The aim of the 2 month randomized controlled trial is to investigate the feasibility of a novel progressive muscle resistance exercise in individuals with low bone mass.
- Conditions
- Osteopenia, Osteoporosis, Postmenopausal Osteoporosis, Sarcopenia
- Trial name
- NCT05060380
- Testing
- Exercise training
- Sponsor
- University of Alabama at Birmingham
Low Vision, Aged
Evaluation of a Standardised Orientation and Mobility Training in Older Adults With Low Vision
The purpose of this study is: 1. to develop a standardised orientation and mobility training (O\&M-training) in the use of an identification/symbol cane by older adults with low vision, and; 2.
- Trial name
- NCT00946062
- Testing
- orientation and mobility training
- Where
- 3 sites in Netherlands
- Volunteers
- 190 people
- Sponsor
- Maastricht University Medical Center
Neuropathic Pain, Spasticity
The Influence of Dry Needling for Hypertonia and Spasticity Treatment on Neuropathic Pain in Lower Extremity of Spinal Cord Injury: A Case Series Study
Spinal cord injury is a life-changing event that places a burden on the healthcare system, including caregivers and affected individuals. Studies do not provide a conclusive incidence rate due to methodological differences.
- Conditions
- Neuropathic Pain, Spasticity, Dry Needling Technique, Spinal Cord Injury
- Trial name
- NCT06954688
- Testing
- dry needling
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Universiteit Antwerpen
Postoperative Delirium, Postoperative Cognitive Dysfunction
Greek Validation of ACE III Test in Perioperative Patients
Postoperative neurocognitive disorders, including postoperative delirium (POD) and postoperaive cognitive dysfunction (POCD), are common complications of perioperative neurocognition in elderly patients undergoing surgery.
- Trial name
- NCT04312516
- Where
- Greece
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Traumatic Brain Injury, Posttraumatic Stress Disorders
Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment
The objective of this study is to evaluate whether use of TRMDU in addition to medication review leads to improved outcomes and reduced health care costs for patients when compared with medication review alone.
- Conditions
- Traumatic Brain Injury, Posttraumatic Stress Disorders, Trauma, Combat Disorders
- Trial name
- NCT01007006
- Testing
- TMRDU
- Where
- 3 sites in United States
- Sponsor
- University of Illinois Chicago
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