Clinical trials: Neurological; Disorder, Nervous System
Autism Spectrum Disorder, Early Developmental Impairment
Multicenter Validation Study on Autism Screening Using a Machine-assisted System
The goal of this observational study is to assess the effectiveness of a machine-assisted system for early screening of autism. The main questions it aims to answer are: Does the machine-assisted system including 5 main…
- Conditions
- Autism Spectrum Disorder, Early Developmental Impairment, Language Development Disorders
- Trial name
- NCT07006948
- Testing
- Autism Diagnostic Observation Schedule, the 2nd edition(ADOS-2), Griffiths Developmental Scales, Chinese edition(GDS-C)
- Where
- 10 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Usher Syndromes
Natural History Study of Usher Syndrome ( Light4Deaf )
Clinical centres in the LIGHT4DEAF consortium have developed and will continue to improve a reliable, early molecular diagnosis and protocols for full clinical characterisation of Usher syndrome, which will be valuable for the…
- Trial name
- Light4Deaf (NCT04665726)
- Where
- 4 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Parkinson Disease
TUS to Disrupt Pathological Oscillations
Scientists and clinicians are interested in measuring and perturbing the signals in the brain - both to better understand normal operation and explore new therapy options for disease.
- Trial name
- NCT06932185
- Testing
- Transcranial Focussed Ultrasound - Active, Transcranial Focussed Ultrasound - Active control
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Chronic Pain, Carpal Tunnel Syndrome
Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome
The purpose of this study is to assess the effects of tDCS in combination with TUS for the treatment of pain in subjects with Carpal Tunnel Syndrome.
- Trial name
- NCT04206215
- Testing
- transcranial Direct Current Stimulation (tDCS), Transcranial Ultrasound (TUS)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Spaulding Rehabilitation Hospital
Narcolepsy Type 1, Narcolepsy Type 2
A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence
Narcolepsy Type 1 (NT1) and Narcolepsy Type 2 (NT2) are rare conditions that make people feel very sleepy during the day (often referred to as excessive daytime sleepiness [EDS]).
- Trial name
- NCT07598708
- Testing
- cleminorexton
- Where
- 26 sites in United States
- Volunteers
- 222 people
- Sponsor
- Centessa Pharmaceuticals (UK) Limited
Sciatica Due to Intervertebral Disc Disorder
Two-leg Rotation and Sciatica
this study including the application of a specific technique of Mulligan mobilization calles 2 leg rotation on patients having lumbar discogenic lesion with sciatica.
- Trial name
- (MWM) (NCT07444125)
- Testing
- standard physical therapy, 2 leg rotation
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- University of Hail
Gynecologic Disease
Quadratus Lumborum Block vs Erector Spinae Plane Block in Laparoscopic Hysterectomy
Postoperative pain following laparoscopic hysterectomy is a challenging concern as some patients suffer acute pain that could let to chronic pain over time following the surgery.
- Trial name
- NCT05465525
- Testing
- Quadratus Lumborum Block Type III, Erector Spinae Plane Block, No Block
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Namik Kemal University
Laryngeal Dystonia, Focal Dystonia
Effects of Neuromodulation in Laryngeal Dystonia
Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life.
- Trial name
- NCT05095740
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Preeclampsia/Eclampsia
Low Dose Magnesium Sulphate Versus Standard Pritchard Regimen In Management Of Severe Preeclampsia/Eclampsia
Background - Preeclampsia/eclampsia, a pregnancy specific multi-systemic disease, is associated with considerable maternal and perinatal morbidity and mortality.
- Trial name
- NCT04501289
- Testing
- Low dose magnesium sulphate, Pritchard regimen
- Where
- Nigeria
- Volunteers
- 114 people
- Sponsor
- Adebayo Joshua Adeniyi
Obesity and Overweight, Sleep Disorder
Overweight and Obesity in Adolescents - Sleep Behavioral Intervention
Sleep plays a crucial role in energy balance, alongside diet and physical activity. Research has linked poor sleep quality and short sleep duration to obesity and cardiometabolic risk, such as insulin resistance and hypertension.
- Trial name
- SLEEP-OB (NCT07255274)
- Testing
- Sleep Behavioral Intervention, Standard Obesity Treatment
- Where
- 2 sites in Portugal
- Volunteers
- 126 people
- Sponsor
- University of Beira Interior
Sarcopenia, Cirrhosis, Liver
Effect of Branch Chain Amino Acid Therapy on Sarcopenia in Children With Chronic Liver Disease.
Sarcopenia is now a well-known complication of cirrhosis and various studies, including pediatric studies, have recognized it as a poor prognostic factor.
- Trial name
- NCT05093218
- Testing
- branch chain amino acid
- Where
- India
- Volunteers
- 44 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Parkinson's Disease, Parkinson
Comparing Biomarker-Guided DBS Programming With Standard Clinical Monopolar Programming
The goal of this clinical trial is to learn whether an objective, data-guided approach to programming deep brain stimulation (DBS) can improve motor outcomes in people with Parkinson's disease who undergo DBS surgery.
- Conditions
- Parkinson's Disease, Parkinson, Parkinsons Disease (PD), Motor Fluctuations
- Trial name
- NCT07369310
- Testing
- Conventional DBS Programming (Monopolar Review), Objective-Guided DBS Programming (Imaging and Local Field Potential-Based)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Tinnitus
Treating Tinnitus Using Eutectic Mixture of Local Anesthetics (EMLA) 5% Cream
The investigators like to learn whether EMLA cream 5% helps tinnitus patients. so far it is known that lidocaine I.V do helps tinnitus but until now it is not clear if topical anaesthetics (e.g EMLA cream) helps tinnitus.
- Trial name
- NCT02266160
- Testing
- EMLA cream 5%, cetomacrogol cream (lotion cream)
- Volunteers
- 142 people
- Sponsor
- HaEmek Medical Center, Israel
Stroke
The Prehospital Selection of Acute Stroke Patients
The aim of this study is to develop and validate a simple prehospital stroke scale, which would predict the presence of large vessel occlusion (LVO) in patients with acute stroke.
- Trial name
- NCT03072524
- Testing
- FAST PLUS test
- Where
- 4 sites in Czechia
- Volunteers
- 400 people
- Sponsor
- University Hospital Ostrava
Benign Paroxysmal Positional Vertigo
Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo
To determine the short term therapeutic efficacies of Gufoni maneuver and mastoid oscillation in apogeotropic type of benign paroxysmal positional vertigo (BPPV) involving the horizontal semicircular canal (HC-BPPV), a…
- Trial name
- NCT02046980
- Testing
- Gufoni, Vibration
- Where
- South Korea
- Volunteers
- 209 people
- Sponsor
- Keimyung University Dongsan Medical Center
Headaches Associated With Subarachnoid Hemorrhage (SAH)
MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH
The purpose of the MIL-SAH trial is to evaluate the efficacy and safety of middle meningeal artery (MMA) lidocaine infusion for the treatment of headache in patients with aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- MIL-SAH (NCT07816159)
- Testing
- Lidocaine hydrochloride, Isotonic saline
- Volunteers
- 90 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bell's Palsy, Facial Paralysis
Combined Effects of Proprioceptive Neuromuscular Facilitation (PNF) and Neural Mobilization on Improving Facial Symmetry in Patients With Bells Palsy
Bell's palsy is an acute,unilateral facial paresis that significantly affects patient's facial symmetry,motor function and quality of life.The primary goal of this randomized controlled trial is to determine if integrating the…
- Conditions
- Bell's Palsy, Facial Paralysis, Facial Asymmetry
- Trial name
- NCT07758543
- Testing
- GROUP A COMBINED THERAPY GROUP, GROUP B PNF GROUP
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Foundation University Islamabad
HIV Infections, Neuropathic Pain
Pain, Inflammation, and Cannabis in HIV
This study will examine how medical cannabis use affects neuropathic pain, inflammation and adverse events in people living with HIV (PLWH) with neuropathic pain.
- Conditions
- HIV Infections, Neuropathic Pain, Cannabis
- Trial name
- PITCH-E (NCT04860089)
- Sponsor
- Montefiore Medical Center
Polymorphism, Sleep Disorder
Polymorphisms, Caffeine and Sleep Disorders
Screening of a population of volunteer workers recruited on the occasion of their occupational health visit, within the Ministry of Defense and civil enterprises.
- Conditions
- Polymorphism, Sleep Disorder, Coffee-Workers' Disease
- Trial name
- SOCAF (NCT03855774)
- Testing
- Polymorphisms
- Where
- France
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche Biomedicale des Armees
Intellectual Disability
Effects of Vocational Rehabilitation Group Intervention on Motivation and Occupational Self-Awareness in Individuals With Intellectual Disabilities
This study is an intervention study that investigates the effects of a group-based approach to motivation and occupational self-awareness of individuals with intellectual disability (ID).
- Trial name
- NCT04728074
- Testing
- The Entering Employment and Sustaining Work Program, vocational rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Hacettepe University
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