Clinical trials: Neurological; Disorder, Nervous System
Pain, Neck
Chronic Neck Pain: Mobility, Sleep, Function
The goal of this observational study is to compare pain, cervical mobility, sleep quality, and functional status between individuals with chronic neck pain (CNP) and healthy individuals.
- Trial name
- observational (NCT06583850)
- Testing
- The Neck Disability Index, Visual analog scale (VAS), Pittsburgh Sleep Quality Index
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Gamze Demircioğlu
Postural Tachycardia Syndrome
Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)
The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).
- Trial name
- NCT01000350
- Testing
- Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Sarcopenia, Asthma
Impact of Sarcopenia on Dyspnea in Patients With Asthma
Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown.
- Conditions
- Sarcopenia, Asthma, Dyspnea, Dyspnea; Asthmatic
- Trial name
- MUDYSA (NCT06870890)
- Testing
- muscle evaluation, Dosage, Cardiopulmonary exercise test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Aphasia, Aphasia, Anomic
Speech Therapy and Repetitive Transcranial Magnetic Stimulation Therapy in Post-stroke Anomic Aphasia
The aim of the study is to observe the effects of speech therapy and transcranial magnetic stimulation therapy in patients who develop anomic aphasia after stroke.
- Conditions
- Aphasia, Aphasia, Anomic, Stroke
- Trial name
- NCT04625790
- Testing
- Repetitive transcranial magnetic stimulation, Speech therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ege University
Primary Progressive Aphasia, Nonfluent Progressive Aphasia
Language Treatment for Progressive Aphasia
Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking.
- Conditions
- Primary Progressive Aphasia, Nonfluent Progressive Aphasia, Semantic Dementia
- Trial name
- NCT00957710
- Testing
- Errorless learning
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Baycrest
Alzheimer's Disease
A 12-week Extension Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
Active treatment extension study of the 331-14-213 trial, to assess the long-term safety and tolerability of oral brexpiprazole as treatment in adult participants with agitation associated with dementia of the Alzheimer's type…
- Trial name
- NCT03594123
- Testing
- Brexpiprazole
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Gonarthrosis, Neuropathic Pain, Nociceptive Pain
Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis
Some people with knee osteoarthritis (gonarthrosis) experience pain differently. In some, the pain is described as "nociceptive" (directly related to the joint), while in others it has "neuropathic" characteristics (related to…
- Trial name
- INDIGO (NCT07668674)
- Testing
- blood sampling, Resting-state functional MRI
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cauda Equina Syndrome, Functional Neurological Disorder
BLB Study Back or Leg Pain and Bladder Symptoms Study
The research focuses on Cauda Equina Syndrome (CES) which describes damage to the nerves in the lower back which supply bladder, bowels, sexual function and the legs usually from slipped discs in the spine.
- Trial name
- BLB (NCT03325374)
- Testing
- Questionnaires and examination
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Lumbar Radiculopathy, Lumbar Disc Herniation
Randomized Evaluation of Lumbar Injection Effectiveness and Function
The goal of this clinical trial is to learn whether the Triojection® System is safe and effective for treating symptomatic lumbar radiculopathy (leg pain caused by nerve irritation or compression) resulting from a contained…
- Conditions
- Lumbar Radiculopathy, Lumbar Disc Herniation, Contained Herniated Lumbar Disc
- Trial name
- RELIEF (NCT07856810)
- Testing
- Triojection® System, Selective Nerve Root Block (SNRB)
- Volunteers
- 300 people
- Sponsor
- SpinaFX Medical Inc.
Alzheimer Disease, Mild Cognitive Impairment
Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants
Phase 1b study to assess the pharmacodynamics, safety, tolerability, and pharmacokinetics of NIO752 in patients with early Alzheimer's disease (AD)
- Trial name
- NCT05469360
- Testing
- NIO752
- Where
- 10 sites in Finland, France and 2 more
- Volunteers
- 38 people
- Sponsor
- Novartis Pharmaceuticals
Analgesia, Robotic Surgery
Interest of Serratus Plane Block in Postoperative Analgesia for Robot-assisted Surgery
The aim of the study is to compare the analgesia provided by the serratus plane block with local infiltration of the orifices of the trocars after thoracic robot-assisted surgery.
- Trial name
- NCT03110120
- Testing
- 0.5% levobupivacaine injectable solution with 10 ml of physiological saline, 0.5% levobupivacaine injectable solution with physiological saline
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Spasticity
Reliability of an Algorithm to Diagnose Spasticity
Spasticity is a condition that results from damage to the central nervous system and causes painful muscle contractures that drastically affect level of independence, activities of daily living, and quality of life.
- Trial name
- NCT01644123
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Acute Repetitive Seizures
Repeat-Dose Pharmacokinetics Study of NRL-1 in Epilepsy Subjects
This study evaluates the pharmacokinetic and safety of NRL-1 in epilepsy subjects. Subjects will receive a single intranasal dose of NRL-1 of either 5 mg, 10 mg, 15 mg or 20 mg and will be based on the subject's body weight.
- Trial name
- NCT02724423
- Testing
- NRL-1
- Where
- 4 sites in United States
- Volunteers
- 57 people
- Sponsor
- Neurelis, Inc.
Muscle Weakness
Facilitating Functional Independence in Patients Receiving Prolonged Mechanical Ventilation
The primary aim of this proposal is to test the effectiveness of neuromuscular electrical stimulation (NMES) in improving functional status and muscle function in patients receiving prolonged mechanical ventilation.
- Trial name
- NCT02847988
- Testing
- Neuromuscular electrical Stimulation (NMES)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- RML Specialty Hospital
Neuropathic Pain, Chronic Postsurgical Pain
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of…
- Trial name
- NeuroPRF (NCT05196503)
- Testing
- Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Phantom Limb Pain (PLP)
Immersive Healing: The Therapeutic Potential of Virtual Reality
Phantom limb pain (PLP) is a significant and pervasive issue among upper limb amputees, severely impacting their quality of life.
- Trial name
- NCT06077227
- Testing
- virtual reality therapy, matched control group
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Intellectual Disability, Mild
Biofeedback Training's Impact on Cognitive and Motor Skills in Kids With Intellectual Disabilities
The expected outcome of the study is to confirm or reject the hypothesis that traditional rehabilitation in combined with biofeedback training produces better results in improving motor and cognitive functions, relative to…
- Trial name
- NCT06120686
- Testing
- Biofeedback method, Conventional therapy program
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Aleksandra Kiper
Shoulder Impingement Syndrome, Chronic Pain
Sensorimotor Cortex Excitability in Shoulder Impingement Syndrome
Shoulder pain is a common musculoskeletal system complaint, accounting for 7-34% of patients in the clinic. The most common shoulder problem is subacromial impingement syndrome (SIS).
- Conditions
- Shoulder Impingement Syndrome, Chronic Pain, Transcranial Magnetic Stimulation, Electroencephalography
- Trial name
- NCT05627986
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Osteoarthritis, Migraine
Migraine and Neuropathic Pain in Osteoarthritis
The goal of this observational study is to estimate the frequency of neuropathic pain and migraines in a group of patients with osteoarthritis of the knees, hips, hands, spine or other joints.
- Conditions
- Osteoarthritis, Migraine, Neuropathic Pain
- Trial name
- MEDUSA (NCT06224959)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postoperative Delirium (POD)
The Study of Postoperative Delirium and Glymphatic System Function in Cardiac Surgery
Postoperative delirium after cardiac surgery is an acute cerebral dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances.
- Trial name
- Delirium (NCT06901479)
- Testing
- Blood was drawn for proteomics testing and Magnetic Resonance Imaging.
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
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