Clinical trials: Neurological; Disorder, Nervous System
Diabetic Macular Edema, Diabetic Retinopathy
Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT)
This is a prospective, observational study designed to evaluate the long-term safety and tolerability of ADVM-022 in participants with diabetic macular edema (DME).
- Trial name
- NCT05607810
- Testing
- ADVM-022
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 22 people
- Sponsor
- Adverum Biotechnologies, Inc.
Seizures
Dilantin Levels With Continuous Delivery of Enteral Feedings - A Pilot Study
It is unclear how enteral nutrition via a feeding tube should be given when a patient is receiving enteral Dilantin. Some caregivers hold the feedings for one hour before and one hour after the Dilantin dose to insure adequate…
- Trial name
- NCT00219479
- Testing
- Phenytoin (Dilantin) levels during change in enteral feeding
- Volunteers
- 3 people
- Sponsor
- Penn State University
Amyotrophic Lateral Sclerosis, Fasciculation
Study to Evaluate Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Appendicular Muscle in Adult Subjects With ALS
The FLX-787-107 study will determine how well FLX-787-ODT works to reduce fasciculations in patients with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT03334786
- Testing
- FLX-787-ODT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Flex Pharma, Inc.
Multiple Sclerosis, Gait Disorders, Neurologic
Pilot Study of Powered Exoskeleton Use for Gait Rehabilitation in Individuals With Multiple Sclerosis
The investigator plans to test the use of the Ekso Bionics® Gait Training (Ekso GT™) exoskeleton for gait training in MS patients. The device will solely be used in the clinic under direct supervision from a physical therapist.
- Trial name
- NCT04000373
- Testing
- Ekso GT™ exoskeleton
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The Cleveland Clinic
Spinocerebellar Degeneration
A Long-Term Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
The purpose of this study is to evaluate the long-term safety, efficacy, and pharmacokinetics of KPS-0373 in SCD patients
- Trial name
- NCT01970124
- Testing
- KPS-0373, High dose, KPS-0373, Low dose
- Where
- Japan
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Coronary Angiography
Effects of Stress Ball Use During Femoral Catheter Removal After Coronary Angiography
This study aimed to evaluate the effects of using a stress ball during femoral catheter removal on quality of recovery, patient comfort, and pain in adults undergoing coronary angiography.
- Trial name
- SB-FCR (NCT07889479)
- Testing
- Stress Ball Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Maltepe University
HIV Infections, HIV Related Neurological Diseases
Determining the Prevalence of HIV-Related Neurological Disorders in the Asia Pacific
This study will determine the prevalence of HIV-related neurological disorders in the countries of the Asia-Pacific Region.
- Trial name
- NCT00168246
- Where
- Australia
- Volunteers
- 600 people
- Sponsor
- National Institute of Mental Health (NIMH)
Fractures, Closed, Pain, Postoperative
Pain and Narcotic Usage After Orthopaedic Surgery
This study aims to 1) observe the course of pain, 2) utilization of opioid pain medication, and 3) possible effect of a behavioral intervention delivered via an automated mobile phone messaging robot in patients undergoing…
- Conditions
- Fractures, Closed, Pain, Postoperative, Pain Catastrophizing, Pain, Acute
- Trial name
- NCT03991546
- Testing
- Acceptance and Commitment Therapy Delivered via an Automated Mobile Messaging Robot
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Christopher Anthony
Tetraplegia/Tetraparesis, Rehabilitation Treatment
Efficacy of Robotic Upper Limb Rehabilitation Training in Patients With Tetraplegia
The goal of this clinical trial is to evaluate the efficacy of upper-limb robotic rehabilitation training (PABLO®) for recovering muscle strength in the scapulohumeral region and the proximal upper limb-compared to standard…
- Conditions
- Tetraplegia/Tetraparesis, Rehabilitation Treatment, Gaining Skeletal Muscle Mass and Strength
- Trial name
- TRRAT (NCT07860827)
- Testing
- Robotic Rehabilitation with PABLO®, Standard Gym Rehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Pain
Use of On-Q Pump for Pain Post C-Section
The main purpose of this study is to examine if pain levels treated with intrathecal (IT) preservative-free morphine (PFM) after a cesarean section improve with the additional use of continuous subfascial wound infiltration with…
- Trial name
- NCT02579629
- Testing
- Ropivacaine 0.1%, Ropivacaine 0.2%, Normal saline
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Emory University
Thymidine Kinase 2 Deficiency
A Retrospective Study of Subjects With Thymidine Kinase 2 Deficiency
This is a multicenter, multinational, retrospective chart-review study to evaluate survival in patients with Thymidine Kinase 2 deficiency (TK2d).
- Trial name
- NCT05017818
- Testing
- Observational retrospective data
- Where
- 12 sites in United States, Russia and 2 more
- Volunteers
- 61 people
- Sponsor
- Zogenix MDS, Inc.
Stroke, Dysphagia
Auricular Vagus Nerve Stimulation and Post-Stroke Dysphagia in Older Adults
This study investigates the effect of non-invasive transcutaneous auricular vagus nerve stimulation (tVNS-E) on swallowing rehabilitation in patients over 70 years old after stroke.
- Trial name
- SVA-DPA (NCT07428590)
- Testing
- tVNS-E active device, tVNS-E inactive device
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Aphasia, Broca
Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients
Aphasia is one of the most disabling complications in language production in patients with left hemisphere stroke. About 19% of patients who experience aphasia may have a spontaneously recovery after several weeks or months.
- Trial name
- Aphasia-ACV (NCT02241213)
- Testing
- Transcranial Magnetic Stimulation (TMS-r)
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Cardiovascular de Colombia
Postherpetic Neuralgia, Diabetic Neuropathy
A Study of the Effectiveness And Safety Of Lidoderm® As Add-On Treatment in Patients With Postherpetic Neuralgia, Diabetic Neuropathy, or Low Back Pain
Patients with a diagnosis of postherpetic neuralgia (PHN), diabetic neuropathy (DN), or low back pain (LBP) who were currently receiving an analgesic regimen that contained gabapentin participated in a Phase IV clinical trial to…
- Conditions
- Postherpetic Neuralgia, Diabetic Neuropathy, Low Back Pain
- Trial name
- NCT00904020
- Testing
- Lidoderm
- Where
- 11 sites in United States
- Volunteers
- 107 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dexmedetomidine, Intrathecal
Dexmedetomidine as an Intrathecal Adjuvant to Hyperbaric Bupivacaine for Postoperative Analgesia in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction Surgeries
This study aimed to evaluate the effect of adding low doses of dexmedetomidine to hyperbaric bupivacaine during spinal anesthesia on post operative analgesia characteristics in Arthroscopic Anterior Cruciate Ligament…
- Conditions
- Dexmedetomidine, Intrathecal, Adjuvant, Hyperbaric Bupivacaine
- Trial name
- NCT06667024
- Testing
- Hyperbaric bupivacaine, Dexmedetomidine and Hyperbaric bupivacaine
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Tanta University
Ataxia Telangiectasia, Growth Failure
Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT)
This study will evaluate the status of the growth hormone/ insulin-like growth factor-1 (GH/IGF-1) axis in relation to growth failure, body weight and composition and neuroprotection in children with Ataxia telangiectasia (AT).
- Trial name
- GHAT (NCT01052623)
- Testing
- Somatropin, Clonidine, L-Arginin-Hydrochloride, Estradiol valerate
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Language and Speech Disorder, Psychiatric Nursing, Mental Health, Pet Therap
The Effect of Animal-Assisted Activity Programme Based on Human Caring Theory on Perceived Stress, Social Adaptation and Communication Skills of Children With Speech and Language Disorders
Animal-assisted practice is an intervention method explained with different mechanisms and theories that provides protection and development of health through human-animal interaction.
- Trial name
- NCT07512180
- Testing
- Nursing Care
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Şeyma Demiralay
Headache, Headache Disorders
Multiomics After Cold Pressor Test of People Who Are Unable to Have Headache
Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in Europe. Despite this high prevalence, there are persons who have never, in their whole life, encountered a headache.
- Conditions
- Headache, Headache Disorders, Healthy
- Trial name
- NCT04220580
- Testing
- Blood samples
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Headache Center
Delirium
Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period
Delirium (acute confusion) is a highly prevalent condition among hospitalized elders with substantial morbidity within the hospital and beyond.
- Trial name
- SHARP (NCT00586196)
- Testing
- donepezil
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
Headache Disorders, Tension-Type Headache
Jaw Muscle Function in Patients With Tension-type Headache
Patients with tension-type headache (TTH) and migraine often experience musculoskeletal complaints, like neck pain and/or jaw pain.
- Trial name
- NCT04196127
- Testing
- Bite force testing
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
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