Clinical trials: Neurological; Disorder, Nervous System
Dementia, Memory Disorders
Preventing Cognitive Decline With Alternative Therapies
Preventing dementia is an important goal for our aging population. This proposal is an initial 42 months study of the effect of standardized ginkgo biloba extract (GBE) on preventing or delaying cognitive decline in people age 85…
- Trial name
- NCT00010920
- Testing
- Ginkgo Biloba Extract
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Problem Behavior
Steps to Effective Problem Solving in Group Homes
Aggressive/challenging behaviors in individuals with intellectual disability are a major public health concern for them, their families, their service programs and staff, and their communities.
- Trial name
- STEPS (NCT02855008)
- Testing
- STEPS, Food for Life
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Enhancing Early Language and Cognitive Development in Toddlers Through a Culturally Adapted Home-based Parent Intervention
Home-Based Language and Cognitive Intervention for Arab Toddlers in Israel
This study evaluates the effectiveness of a culturally adapted, home-based program designed to improve language and cognitive development in Arab toddlers in Israel.
- Trial name
- CAHBI-T (NCT07233525)
- Testing
- Culturally Adapted Parent-Implemented Intervention, Child Health Education Sessions
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- Hillel Yaffe Medical Center
Swelling/ Edema, Trismus
The Effect of Dexamethasone Submucosal Injection After Surgical Extraction of Lower Impacted Third Molars on Trismus and Edema
This clinical trial aims to investigate whether dexamethasone decreases edema and trismus in adults undergoing lower third molar surgical extraction.
- Trial name
- NCT06953440
- Testing
- Dexamethasone Sodium Phosphate Injection
- Where
- Saudi Arabia
- Volunteers
- 66 people
- Sponsor
- King Abdulaziz University
Essential Tremor, Dystonia
Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement Disorders
The aim of this study is to asses the efficacy and the clinical safety of the transcranial magnetic resonance guided high intensity focused ultrasound system ExAblate 4000, InSightec Ltd.
- Conditions
- Essential Tremor, Dystonia, Parkinson's Disease
- Trial name
- NCT01698450
- Testing
- Non-invasive intervention with focused ultrasound (ExAblate 4000)
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University Children's Hospital, Zurich
Gait Disorders, Neurologic, Artificial Intelligence
Deep Neural Network for Stroke Patient Gait Analysis and Classification
Lower limbs of stroke patients gradually recover through Brunnstrom stages, from initial flaccid status to gradually increased spasticity, and eventually decreased spasticitiy. Throughout this process.
- Trial name
- NCT04968418
- Testing
- APDM OPAL system wearable IMU
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cheng-Hsin General Hospital
Spinal Cord Injuries, Gait Disorders, Neurologic
Safety and Feasibility of TWIICE Rise
The aim of this study is to assess the safety and the feasibility of two versions of TWIICE Rise for exoskeleton-assisted ambulation in patients with a spinal cord injury.
- Trial name
- NCT05926310
- Testing
- TWIICE Rise
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- TWIICE
Neurodegenerative Diseases, Behavioral Symptoms
Impact of Harp Therapy on Behavioral Disorders in Nursing Home Residents With Neurodegenerative Disease (ARPE)
The ARPE study looked at whether weekly harp therapy sessions could reduce behavioral problems in older adults living in memory care units of a nursing home (EHPAD).
- Conditions
- Neurodegenerative Diseases, Behavioral Symptoms, Dementia, Agitation
- Trial name
- ARPE (NCT07748013)
- Testing
- Harp therapy (receptive music therapy)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- LNA SANTE
Alzheimer Disease, Dementia
HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
This randomized controlled trial study aims to evaluate a revised hearing care intervention for older adults with Alzheimer's Disease and Related Dementias (ADRD).
- Conditions
- Alzheimer Disease, Dementia, Hearing Loss, Cognitive Impairment
- Trial name
- HEARS-NPS (NCT06930560)
- Testing
- HEARS-NPS device, HEARS-NPS program
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Muscular Atrophy
Resistive/Cardiovascular Training Study
This is a training study in healthy volunteers to characterize gains in lower-body resistive strength and cardiovascular capacity with exercise on a Combined Countermeasure Device (CCD) we have developed for the National Space…
- Trial name
- CCD (NCT00835601)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sarcopenia, Aged
HIT Training in the Frail Elderly.
This pilot study aims to investigate whether high intensity interval training can result in rapid improvements in physical fitness amongst the frail elderly (over 70 years old).
- Conditions
- Sarcopenia, Aged, Exercise, Preoperative Care
- Trial name
- eHIT (NCT03138265)
- Testing
- HIIT Device: ergometer
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parkinson's Disease, Dysarthria
A Comparison of Voice Amplifiers and Personal Communication Systems in Individuals With Parkinson's Disease
This study will compare two types of assistive devices for communication (a voice amplifier and a personal communication system) in individuals with a speech disorder related to Parkinson's disease.
- Trial name
- NCT02407067
- Testing
- ChatterVox, Easy Listener FM system (Phonic Ear Corp.)
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Neuromuscular Blockade Reversal Agent, Perioperative Complications
Sugammadex-Induced Clenching During Neuromuscular Blockade Reversal
Study Objective: This study aims to evaluate the incidence, severity, and risk factors of sugammadex-induced mouth clenching during neuromuscular blockade (NMB) reversal in adult surgical patients.
- Conditions
- Neuromuscular Blockade Reversal Agent, Perioperative Complications, Anesthesia, General, Sugammadex
- Trial name
- NCT06962007
- Testing
- Sugammadex 1 mg/kg Group, Sugammadex 2 mg/kg Group, Sugammadex 4 mg/kg Group
- Where
- South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Smith-Lemli-Opitz Syndrome
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
This study will evaluate the safety and effectiveness of simvastatin in treating children with Smith-Lemli-Opitz syndrome (SLOS).
- Trial name
- NCT00064792
- Testing
- Simvastatin Susp., OraPlus
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Forbes Porter, M.D.
Mild Traumatic Brain Injury, Photophobia
Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury
The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in…
- Trial name
- NCT06109909
- Testing
- Micro Current Neurofeedback Device using Low-Frequency Pulse-Based Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Stroke, Upper Limb Paresis
Thermal Stimulation for Stroke Patients
Sensory and/or motor deficits in upper limb following stroke often have negative impacts on their daily living. Thermal stimulation with hot and cold pack alternatively incorporated into conventional rehabilitation has been…
- Trial name
- TSSP (NCT01658293)
- Testing
- thermal stimulation, control group ergometer exercises
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Oral Surgery
Pilot Study: Effect of Dexamethasone vs Vicodin in Reducing Post-operative Pain
The main objective of the pilot study is to investigate the process that includes recruitment (to estimate the rate of enrollment), feasibility, protocol refinement, and willingness of the subject to be randomized.
- Trial name
- NCT04008043
- Testing
- Vicodin, Dexamethasone
- Where
- United States
- Sponsor
- Boston University
Strabismus
Pain After Strabismus Surgery
At Ann \& Robert H. Lurie Children's Hospital of Chicago (Lurie Children's), the current practice is to prescribe children with oral Tylenol as needed every 4-6 hours post strabismus surgery.
- Trial name
- NCT06689943
- Testing
- Tylenol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Seizures, Encephalopathy
The Impact of Electroencephalographic (EEG) Seizure Treatment in Neonatal Encephalopathy
This is a prospective, randomized, single-center pilot trial of term and near term (≥ 36 weeks gestation) infants with encephalopathy or seizures comparing a "EEG Seizure Treatment Group" or ESG with a "Clinical Seizure Treatment…
- Trial name
- NCT01027715
- Testing
- EEG monitoring and treatment of EEG seizures
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Washington University School of Medicine
Hearing Loss
Hearing Preservation Using Dexamethasone and Hyaluronic Acid for Cochlear Implantation
The objective of the present study is to investigate the effect dexamethasone and hyaluronic acid have on hearing preservation
- Trial name
- NCT01588925
- Testing
- Cochlear Implantation, Cochlear Implantation+dexamethasone, Cochlear Implantation+dexamethasone+hyaluronic acid
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- University of Sao Paulo General Hospital
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