Clinical trials: Neurological; Disorder, Nervous System
Neurological Rehabilitation, Stroke
Effects of Repetitive Transcranial Magnetic Stimulation Therapy on Lower Extremity Motor Development in Stroke Patients
The aim of our study is to investigate the effects of rTMS applications at different current frequencies (low frequency / intermittent (intermittent) theta burst (iTBS)) in stroke patients on lower extremity motor development…
- Conditions
- Neurological Rehabilitation, Stroke, Lower Extremity Problem, Quality of Life
- Trial name
- NCT05554861
- Testing
- Low Frequency rTMS Protocol, Intermittent Theta Burst Stimulation (iTBS) Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Afyonkarahisar Health Sciences University
Hearing Loss
Auditory Research in Children Living With HIV Exposure-uninfected (ARCHIVE)
To evaluate the association of in utero antiretroviral therapy (ART) exposure and hearing abilities of children who were perinatally HIV-exposed, but HIV-free, stratified by timing of maternal ART initiation.
- Trial name
- ARCHIVE (NCT06635642)
- Testing
- Dichotic Interaural Intensity Difference (DIID) Training
- Volunteers
- healthy volunteers welcome
- Sponsor
- San Diego State University
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Fragile X Syndrome (FXS), Autism Spectrum Disorder
Group CBT in Adolescents With Fragile X Syndrome and in Adolescents With Autism Spectrum Disorder
Fragile X Syndrome (FXS) is a rare genetic syndrome, caused by a mutation in the FMR1 gene located on the X chromosome. It is considered the leading hereditary cause of intellectual disability (ID) and the primary cause of Autism…
- Trial name
- NCT06677866
- Testing
- Cognitive behavioral therapy, Waiting List
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Neuropathic Pain, Spinal Cord Injuries
Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain
This study is a phase IV clinical trial with the objective of evaluating whether pain relief associated with pregabalin for at-level non-evoked and evoked neuropathic pain is more efficient during the early rather than late…
- Trial name
- NCT01479556
- Testing
- Pregabalin
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Julian Taylor Green
Lafora Disease
Natural History and Functional Status Study of Patients With Lafora Disease
A natural history and functional status study to characterize the clinical disease course in Lafora disease patients using standardized, quantitative evaluations and to identify useful biomarkers and clinical outcome measures for…
- Trial name
- NCT03876522
- Where
- 4 sites in United States, Italy and 1 more
- Volunteers
- 33 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Gastrointestinal Cancer, Sarcopenia
Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery
This prospective observational study aims to evaluate the effects of sarcopenia on intraoperative neuromuscular block (NMB) in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Cancer, Sarcopenia, Neuromuscular Blockade
- Trial name
- NCT07003061
- Testing
- Standard Anesthesia Management
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Painful Diabetic Neuropathy
Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy
The primary objective of the study is to collect preliminary information on the effect of three doses of trazodone/gabapentin FDC products on pain intensity in patients with painful diabetic neuropathy after 8-week treatment…
- Trial name
- NCT03749642
- Testing
- trazodone/gabapentin 2.5/25 mg, trazodone/gabapentin 5/50 mg, trazodone/gabapentin 10/100
- Where
- 30 sites in Czechia, France and 2 more
- Volunteers
- 240 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Parkinson Disease, Dyskinesias
Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics
The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose.
- Trial name
- DYSK-PD-2007 (NCT00888186)
- Testing
- levodopa/carbidopa
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Uppsala University
Spastic Neurogenic Bladder
The Efficacy of Botulinum Toxin in Spastic Neuropathic Bladder
To assess the efficacy of botulinum toxin in spastic neurogenic bladder.
- Trial name
- NCT03407183
- Testing
- intradetrusor injection of botulinumtoxinA (Botox)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- AHMED FARAHAT HASSAN
HIV Infections, Sleep Disorder
Assessment of Sleep Disordersin People Living With HIV in the Era of New Antiretroviral Therapies in North of France
People living with HIV (PLHIV) appear to present with sleep-related complaints more frequently than the general population, with a prevalence of 50-70%. The latest French multi-center epidemiological data are dated.
- Trial name
- SANDMAN (NCT06441383)
- Testing
- Pittsburgh Sleep Quality Index
- Where
- France
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Tourcoing Hospital
Stroke
Extern Validation of a Predictive Score of Brain Death in Severe Stroke (DIAPASON1)
There is currently a shortage of organ in France, for patients with chronic diseases who are on the waiting list for an organ. The first source of organ donor in France is patients with brain death.
- Trial name
- DIAPASON1 (NCT03612141)
- Where
- 25 sites in France
- Volunteers
- 650 people
- Sponsor
- Central Hospital, Nancy, France
Anesthesia, Sedation and Analgesia
Prospective IR-led Sedation Feasibility
This study wants to see if some interventional radiology (IR) procedures can be done without using general anesthesia. General anesthesia needs a lot of staff and equipment. It can also cause side effects.
- Conditions
- Anesthesia, Sedation and Analgesia, Interventional Radiology
- Trial name
- NCT07443254
- Testing
- ketamine, Fentanyl (IV), Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- CAMC Health System
Pain Management
Effect of Chewing Different Flavor Gum on Procedural Pain and Fear
Needle-related pain and anxiety present persistent challenges in pediatric clinical procedures. This study aims to investigate the effects of chewing sugared and sugar-free gum on pain, anxiety, and fear in children undergoing…
- Trial name
- Gum-Pain (NCT07326254)
- Testing
- Sugared Gum Chewing, Sugar-Free Gum Chewing, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
CVA, Gait, Hemiplegic
Robotic Exoskeleton Assisted Gait Post Stroke
The current investigation takes advantage of both a progressive and adaptive assist-as-needed massed practice and time-sensitive neuroplasticity through exoskeleton assisted walking in order to induce greater recovery-oriented…
- Trial name
- RE-Assist (NCT04309305)
- Testing
- EksoGT™, Ekso Bionics, Berkley, CA, USA, Standard of Care, No Intervention
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Spinal Cord Injuries, Neuropathic Pain
Virtual Reality for Chronic Neuropathic Pain
The investigators hypothesize that SCI patients using immersive IVR training will show improved reduction of neuropathic pain that will outlast the training sessions and transfers into daily life.
- Trial name
- NCT03592394
- Testing
- Immersive Virtual Reality (Gear VR)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kathleen Friel
Sleep Disorder
Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ABT-652 in Subjects With Excessive Daytime Sleepiness
The main purpose of this study is to evaluate the safety and tolerability of the drug ABT-652 given once daily to people with excessive daytime sleepiness.
- Trial name
- NCT01124851
- Testing
- ABT-652
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Abbott
Prematurity, Parenting
Study of the Quality of Sleep of Parents of Premature Children Compared to Parents of Full-term Children
This study evaluate the incidence of sleep disorders in parents of premature children hospitalized in unit care of neonatalogy or intensive unit care of neonatalogy, compared to parents of full-term child in maternity.
- Conditions
- Prematurity, Parenting, Sleep Deprivation
- Trial name
- SLEEP-PP (NCT03693651)
- Where
- France
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Stroke, Hemiplegia
Robot-Assisted Therapy in Chronic Stroke Patients
Considering the paucity of studies on robotic hand therapy, larger-scale and long-term follow-up studies are needed. The aim in this study is to demonstrate the effectiveness of robot-assisted hand therapy in patients with…
- Trial name
- NCT06692829
- Testing
- robotic rehabilitation, conventional rehabilitation
- Volunteers
- 80 people
- Sponsor
- Afyonkarahisar Health Sciences University
Laryngeal Injuries
Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium
Anesthesia induction with sevoflurane is not associated with an increased incidence or severity of laryngeal injuries compared with an anesthesia induction with a muscle relaxant.
- Trial name
- NCT01591031
- Testing
- Sevoflurane, Rocuronium
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Rostock
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