Clinical trials: Neurological Condition
Low Back Pain, Migraine
Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain
The purpose of this study is to evaluate the safety and tolerability of OraVescent fentanyl for the potential treatment of breakthrough pain episodes in patients who have chronic noncancer pain.
- Conditions
- Low Back Pain, Migraine, Diabetic Neuropathies, Osteoarthritis
- Trial name
- NCT00228605
- Testing
- OraVescent Fentanyl
- Where
- 38 sites in United States
- Volunteers
- 500 people
- Sponsor
- Cephalon
Acute Pain
A Phase 1 Dose Escalation Study of Oral VX-708 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple ascending doses of VX-708 in healthy participants.
- Trial name
- NCT05347394
- Testing
- VX-708
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain
A Study Comparing Vicodin® CR and NORCO® to Placebo in Subjects With Acute Pain Following Bunionectomy
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of Extended Release Hydrocodone/Acetaminophen and Immediate Release Hydrocodone/Acetaminophen with placebo over a…
- Trial name
- NCT00404222
- Testing
- Hydrocodone/Acetaminophen Extended-Release, Hydrocodone/Acetaminophen Immediate Release (NORCO®)
- Volunteers
- 90 people
- Sponsor
- Abbott
Idiopathic Parkinson's Disease
Trial to Evaluate The Efficacy Of Rotigotine on Parkinson's Disease-Associated Motor Symptoms And Apathy
This trial is being conducted to assess the effects of Rotigotine over Placebo on improvement of Apathy and motor symptoms in subjects with early-stage and advanced stage idiopathic Parkinson´s Disease.
- Trial name
- BRIGHT (NCT01782222)
- Testing
- Rotigotine
- Where
- 42 sites in United States, Austria and 5 more
- Volunteers
- 122 people
- Sponsor
- UCB BIOSCIENCES GmbH
Shoulder Impingement Syndrome
Randomized Clinical Trial of Rehabilitation for Subacromial Impingement Syndrome
The purpose of this randomized double-blind clinical trial is to determine the effectiveness of manual therapy for patients with subacromial impingement syndrome of the shoulder.
- Trial name
- NCT00633451
- Testing
- Manual Therapy and Exercise, Exercise Only
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Proaxis Therapy
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety Study of Carotid Body Neurostimulation to Treat Cerebral Vasospasm
The purpose of this study is to evaluate the safety and performance of the Delta system in the treatment of cerebral vasospasm post aneurysmal subarachnoid hemorrhage (aSAH) patients.
- Trial name
- NCT02129413
- Testing
- Delta system
- Where
- 7 sites in Czechia, Germany and 1 more
- Volunteers
- 23 people
- Sponsor
- Samson NeuroSciences
Stable Angina Pectoris
Efficacy and Safety Study of Total Flavonoids of Propolis Dropping Pill to Treat Angina Pectoris
The purpose of this study is to confirm the efficacy and safety of total flavonoids of propolis dropping pill to treat angina pectoris, evaluated by total exercise time of treadmill exercise test.
- Trial name
- NCT01453582
- Testing
- Total Flavonoids of Propolis dropping pill
- Where
- 13 sites in China
- Volunteers
- 478 people
- Sponsor
- Shanghai Greenvalley Pharmaceutical Co., Ltd.
Drug Resistant Epilepsy, Seizure
NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy
To evaluate the safety and efficacy of using NaviFUS™ system in patients with drug resistant epilepsy
- Conditions
- Drug Resistant Epilepsy, Seizure, Seizure Disorder, Epilepsy
- Trial name
- NCT04999046
- Testing
- NaviFUS System
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- NaviFUS Corporation
Migraine
Efficacy and Safety of BGG492 in the Treatment of Migraine
This study will assess the efficacy and safety of BGG492 used to treat migraine pain.
- Trial name
- NCT00892203
- Testing
- BGG492, Sumatriptan
- Where
- 13 sites in United States, Germany and 1 more
- Volunteers
- 75 people
- Sponsor
- Novartis
Nasolabial Folds Correction, Pain
Safety and Efficacy Study of Lidocaine Mixed Hyaluronate on Nasolabial Folds Correction
This clinical trial is a double-blind, randomized, within-subject controlled, 2-armed, single-center study sponsored by SciVision Biotech Inc. and approved by National Taiwan University Hospital Research Ethics Committee.
- Trial name
- NCT02006173
- Testing
- Lidocaine, Normal Saline
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- SciVision Biotech Inc.
Post-Exercise Recovery, Muscle Soreness
Shower Gel and Participant-Reported Post-Exercise Soreness in Regular Exercisers
The objective of this study is to evaluate any potential claims for a topical shower gel product about perceived recovery and other aspects of user experience and consumer satisfaction following HYROX exercise training.
- Trial name
- NCT07908290
- Testing
- Topical shower gel, Comparator
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Humanix
Rett Syndrome, RTT
A Long-term Safety Study of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome
This study will be conducted to evaluate the long-term safety of cannabidiol oral solution (GWP42003-P, CBD-OS) in participants with Rett syndrome.
- Trial name
- NCT04252586
- Testing
- GWP42003-P
- Where
- 31 sites in United States, Australia and 4 more
- Volunteers
- 21 people
- Sponsor
- Jazz Pharmaceuticals
Status Epilepticus
Randomized Therapy In Status Epilepticus
This study evaluated the effectiveness and safety of an investigational product (IP), intravenous (IV) ganaxolone, to treat participants with status epilepticus (SE).
- Trial name
- RAISE (NCT04391569)
- Testing
- Ganaxolone
- Where
- 74 sites in United States, Australia and 1 more
- Volunteers
- 100 people
- Sponsor
- Marinus Pharmaceuticals
Drug-resistant Epilepsy, Focal-Onset Seizures
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
The purpose of the study is to characterize the dose-response relationship with respect to efficacy of Padsevonil administered concomitantly with up to 3 anti-epileptic drugs (AEDs) for treatment of observable focal-onset…
- Trial name
- ARISE (NCT03373383)
- Testing
- Padsevonil
- Where
- 148 sites in United States, Australia and 17 more
- Volunteers
- 411 people
- Sponsor
- UCB Biopharma S.P.R.L.
Parkinson's Disease
A Study to Evaluate Fixed Dose Carbidopa/Levodopa/Entacapone Versus Immediate Release Carbidopa/Levodopa
The purpose of this study is to achieve approval for the use of carbidopa/levodopa/entacapone in early Parkinson's disease (PD) by demonstrating that when used as initial levodopa therapy in early PD…
- Trial name
- NCT00134966
- Testing
- capsules containing: carbidopa (25 mg), levodopa (100 mg), entacapone (200 mg)
- Where
- 60 sites in United States, Canada and 6 more
- Volunteers
- 493 people
- Sponsor
- Novartis
Urinary Bladder, Neurogenic
Open-label Long-term Extension Study of Fesoterodine in Japanese Subjects With Neurogenic Detrusor Overactivity.
The purpose of this study is to investigate the safety and tolerability of fesoterodine following once daily long-term treatment in Japanese pediatric neurogenic detrusor overactivity (NDO) subjects.
- Trial name
- NCT02501928
- Testing
- Fesoterodine PR 4 mg, Fesoterodine PR 8 mg, Fesoterodine BIC 2 mg
- Where
- 7 sites in Japan
- Volunteers
- 12 people
- Sponsor
- Pfizer
Cancer Pain
Study to Evaluate Effectiveness and Tolerability of OROS Hydromorphone for Cancer Pain Treatment in Korean Patients
The purpose of this study is to evaluate the effectiveness and tolerability of Once-Daily OROS ("Osmotic Release Oral System" [a controlled release oral medication delivery system in the form of a tablet]) hydromorphone for…
- Trial name
- NCT01621100
- Testing
- OROS hydromorphone
- Where
- 6 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Janssen Korea, Ltd., Korea
Headache
Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache
The purpose of this trial is to determine if a single, oral dose of a fast release aspirin 1000 mg provides relief compared to acetaminophen 1000 mg and placebo in subjects with tension-type headache pain.
- Trial name
- Tarot Headache (NCT01552798)
- Testing
- Acetylsalicylic acid (Aspirin, BAY1019036), Acetaminophen
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bayer
Intractable Pain, Back Pain
Prometra's Utilization in Mitigating Pain II
Intrathecal infusion pumps are increasingly used to deliver analgesics for chronic intractable pain. The PUMP II trial is designed to evaluate the ongoing safety and efficacy of the new Prometra® Programmable Pump System for…
- Conditions
- Intractable Pain, Back Pain, Leg Pain, Arm Pain
- Trial name
- (PUMP 2) (NCT00866164)
- Testing
- Prometra Programmable Pump
- Sponsor
- Flowonix Medical
Sleep Disorder
A Prospective Study to Evaluate the WP in Comparison to PSG in Patients Suspected of Sleep Disorders
The current study is a prospective blinded study to collect data regarding the performance of the WP device in detecting sleep disorders.
- Trial name
- NCT06093633
- Where
- 3 sites in United States, Israel
- Volunteers
- 600 people
- Sponsor
- Itamar-Medical, Israel
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