Clinical trials: Neurological Condition
Myasthenia Gravis, Generalized
Study of Telitacicept in Generalized Myasthenia Gravis
The purpose of this study is to evaluate the efficacy and safety of Telitacicept in the treatment of patients with generalized myasthenia gravis.
- Trial name
- NCT05737160
- Testing
- Telitacicept
- Where
- 51 sites in China
- Volunteers
- 114 people
- Sponsor
- RemeGen Co., Ltd.
Metastatic Lesions in Vertebral Bodies
Evaluation of t-RFA and RF-TVA Prior to/Following Radiation Therapy to Treat Painful Metastatic Vertebral Body Tumor(s)
The purpose of this study is to evaluate treating painful metastatic lesions in vertebral bodies with pathologic fractures with targeted radiofrequency ablation (t-RFA) and vertebral augmentation (VA) prior to or following…
- Trial name
- STARRT (NCT02225223)
- Testing
- STAR™ Tumor Ablation System, StabiliT® Vertebral Augmentation System
- Where
- 14 sites in United States
- Volunteers
- 35 people
- Sponsor
- Merit Medical Systems, Inc.
Post Surgical Ocular Inflammation
A Study of TRS01 in Participants With Post-surgical Ocular Inflammation
The objective of this study is to evaluate the safety and preliminary efficacy of TRS01 eye drops as compared to placebo on participants with ocular inflammation after cataract surgery.
- Trial name
- NCT04222725
- Testing
- TRS01 eye drops
- Where
- 5 sites in United States
- Volunteers
- 37 people
- Sponsor
- Tarsier Pharma
Pain
TENS and Heat for Reducing Back Pain in Humans
Lower back pain is one of the most common and most expensive impairments costing time and expense in the work force today. With the effects on cognitive skills and addictive side effects of opioids and other prescription pain…
- Trial name
- NCT03740750
- Testing
- Thermacare heat wraps, TENS
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Future Sciene Technology
Osteoarthritis, Muscle Pain
An Bioequivalence Study of Loxoprofen Sodium Patches in Healthy Volunteers
This study was a single-center, randomized, open-label, two-agent, two-cycle, double-cross bioequivalence trial.
- Conditions
- Osteoarthritis, Muscle Pain, Swelling Muscle
- Trial name
- NCT06510413
- Testing
- Loxoprofen Sodium Patches(reference product), Loxoprofen Sodium Patches(test product )
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Frontier Biotechnologies Inc.
Pain, Postoperative
An Open-Label Functionality, Safety and Efficacy Study in Patients Undergoing Elective Unilateral Knee Replacement
This study is being performed to evaluate the functionality of a device (Sufentanil NanoTab® PCA System) that has been developed for use by patients to self-administer the ARX-F01 pain medication (Sufentanil NanoTab 15 mcg) for…
- Trial name
- NCT00859313
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Talphera, Inc
Advanced Parkinson's Disease
Observational Study Evaluating Long-Term Effectiveness of Duodopa/Duopa in Patients With Advanced Parkinson's Disease
This study is a non-interventional post-marketing observational study (PMOS) of participants with advanced Parkinson's disease (PD) treated with Duodopa/Duopa in a routine clinical setting.
- Trial name
- DUOGLOBE (NCT02611713)
- Where
- 54 sites in United States, Australia and 8 more
- Volunteers
- 213 people
- Sponsor
- AbbVie
Pain, Migraine
Efficacy and Safety of Acetaminophen, Aspirin and Caffeine With Sumatriptan in the Acute Treatment of Migraine
The main purpose of this study is to compare the efficacy and safety of aspirin, acetaminophen and caffeine (AAC) with sumatriptan and placebo in the acute treatment of migraine.
- Trial name
- NCT01248468
- Testing
- Aspirin, acetaminophen and caffeine, Sumatriptan
- Where
- 20 sites in United States
- Volunteers
- 752 people
- Sponsor
- Novartis
Spinal Stenosis, Low Back Pain
Total Facet Arthroplasty System®(TFAS®) Clinical Trial
The Archus Total Facet Arthroplasty System® (TFAS®) is a non-fusion spinal implant indicated for treatment of patients with moderate to severe spinal stenosis. TFAS® replaces the diseased facets following surgical removal.
- Conditions
- Spinal Stenosis, Low Back Pain, Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- NCT00418197
- Testing
- Total Facet Arthroplasty System® (TFAS®)
- Volunteers
- 450 people
- Sponsor
- Archus Orthopedics, Inc.
Procedural Anxiety, Procedural Pain
Nebulized Lidocaine and Intranasal Midazolam for NGT Insertion in Children
Nasogastric tube (NGT) is a commonly performed procedure in the Emergency Department. Although it is not a major procedure, it is usually associated with a bad experience and cause discomfort and pain in kids.
- Trial name
- NCT04571879
- Testing
- Nebulized Lidocaine, Intranasal Midazolam
- Where
- 2 sites in Qatar
- Volunteers
- 48 people
- Sponsor
- Hamad Medical Corporation
Low Back Pain
A Study to Investigate the Effect of a New Postural Bio-feedback Device on Low Back Pain
A postural bio-feedback device worn by subjects for 4-10 hours a day for 6 days spread across 6 weeks for the sub acute low back pain group and for 8 days spread across 10 weeks for the chronic group.
- Trial name
- NCT01572779
- Testing
- BSM device with bio-feedback, BSM device with no bio-feedback
- Where
- 9 sites in Australia
- Volunteers
- 112 people
- Sponsor
- Pro-Active Medical Pty Ltd
Pain
A Bioequivalence Study of a New Paracetamol Oral Suspension 24mg/ml Compared to the Marketed Paracetamol Oral Suspension (Panadol Baby and Infant 24mg/ml) in Healthy Adult Subjects
The objective of the study is to compare the bioequivalence of a New Paracetamol Oral Suspension 24 milligram/milliliter (mg/ml) with that of an already approved Paracetamol (24 mg/ml) Oral Suspension (Panadol Baby \& Infant)…
- Trial name
- NCT05022810
- Testing
- New Paracetamol Oral Suspension (24 mg/ml), Panadol B&I Oral Suspension (24 mg/ml paracetamol)
- Where
- Czechia
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- HALEON
Chronic Pain
Impact of QoLibri Medical Device on the Consequences of Chronic Pain: a Randomized Controlled Trial
A superiority study evaluating the impact of the QoLibri Software as Medical Device on functional and psychological consequences of chronic pain in primary care patients.
- Trial name
- QoLiDoc (NCT06841276)
- Testing
- QoLibri Digital Therapy
- Where
- France
- Volunteers
- 410 people
- Sponsor
- Novesia
Complete Motor Paraplegia
Assessment of the Interest of the Atalante Device for Patients With Manual Wheelchairs
The loss of standing and walking capabilities in a paraplegic person is most often the result of damage to the spinal cord, either traumatic (accidental) or pathological and has both a somatic and a psychological impact on the…
- Trial name
- M1-M2 (NCT05909774)
- Testing
- Test with Atalante exoskeleton in "continuous walk" type
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Wandercraft
Migraine
Cefalium® Compared to Tylenol® in the Treatment of Migraine Attacks
National clinical trials, phase III, randomized, open, parallel, study of superiority, in which three hundred thirty-six (336) participants of both sexes, aged between 18 and 65 years will be randomly allocated to one of two…
- Trial name
- NCT02582996
- Testing
- Acetaminophen+Caffeine+Dihydroergotamine+Metoclopramide., Acetaminophen
- Where
- 6 sites in Brazil
- Volunteers
- 336 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Constipation
Optimisation of Hydromorphone - Naloxone Ratio for the Treatment of Pain
The purpose of this study is to establish an optimal hydromorphone - naloxone ratio with an improved bowel function for constipated pain patients.
- Trial name
- HMX3501 (NCT00992576)
- Testing
- Active Hydromorphone PR + Active Naloxone PR
- Where
- 14 sites in Australia, Austria and 12 more
- Volunteers
- 600 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Pain
A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain
This is a multicenter randomized, double-blind, placebo-controlled phase 2 study to evaluate efficacy, safety, tolerability, pharmacokinetics, and target engagement of GSK3858279 in adult participants with chronic Diabetic…
- Trial name
- NEPTUNE-17 (NCT05838755)
- Testing
- GSK3858279
- Where
- 81 sites in United States, Canada and 9 more
- Volunteers
- 147 people
- Sponsor
- GlaxoSmithKline
Stroke, Neurologic Diseases, General
Cerebril™ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy
The main objective of this study is to evaluate the safety, tolerability and pharmacokinetics of Cerebril™ in Cerebral Amyloid Angiopathy (CAA) patients who have had lobar cerebral hemorrhage.
- Trial name
- NCT00056238
- Testing
- NC-758 (Anti amyloidotic [Aß] agent)
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Bellus Health Inc. - a GSK company
Painful Diabetic Neuropathy
A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y
This trial is assessing the analgesic efficacy and safety of a new central analgesic in subjects with pain due to diabetic peripheral neuropathy (DPN).
- Trial name
- NCT01056315
- Testing
- GRT3938Y
- Where
- 61 sites in United States
- Volunteers
- 553 people
- Sponsor
- Grünenthal GmbH
Hearing Loss
A Comparison of Hearing Aid Fitting Methods
This investigation will compare hearing aid fitting methods between self-fitting and clinician fitting approaches by using a standardized questionnaire to evaluate subjective hearing aid benefit.
- Trial name
- NCT05376215
- Testing
- Experimental hearing aid
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Sonova AG
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