Clinical trials: Neurological Condition
Pain, Postoperative, Postoperative Nausea and Vomiting
Dexamethasone for Post-cesarean Delivery Pain
The purpose of this study is to compare post-cesarean section consumption of pain medication between two groups of patients undergoing scheduled cesarean section at term gestation who receive a single-dose of intraoperative…
- Trial name
- NCT01812057
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Duke University
Overactive Bladder
Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?
The purpose of this research study is to help determine if 10 injections of Botox ® 100 units is less painful than 20 injections of Botox ® 100 units based on effectiveness in reducing urge incontinence episodes.
- Trial name
- NCT04124939
- Testing
- OnabotulinumtoxinA 100 Units
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Adolescent Behavior, Intellectual Disability
Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities
The objective of this study is to compare the effect of two strategies to increase MVPA in adolescents with intellectual and developmental disabilities (IDD): a single level intervention delivered to the adolescent only, and a…
- Conditions
- Adolescent Behavior, Intellectual Disability, Down Syndrome, Physical Activity
- Trial name
- NCT03684512
- Testing
- Group Exercise Sessions, Individual Support Sessions, Facebook Group
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of Kansas
Ambulation Difficulty, Gait, Unsteady
The Sensorimotor Locus of Balance Control in Elderly Gait
The aging population is at an exceptionally high risk of debilitating falls, contributing significantly to reduced independence and quality of life.
- Conditions
- Ambulation Difficulty, Gait, Unsteady, Fall, Position Sense Disorders
- Trial name
- NCT03341728
- Testing
- Optical flow perturbations, Normal walking
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Amblyopia
Regimens of Intermittent Occlusion Therapy for Amblyopia in Children
This study is designed to answer the question: What if the Intermittent Occlusion (IO-therapy) glasses were prescribed all day (12-hours) in which the total time of treatment only took 4 weeks instead of the current treatment…
- Trial name
- NCT02767856
- Testing
- IO-therapy Glasses
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Salus University
Stroke, Cerebrovascular Accident
Spinal Plasticity to Enhance Motor Retraining After Stroke
The objective of this project is to study the effects of an emerging noninvasive neuromodulation strategy in human stroke survivors with movement-related disability.
- Conditions
- Stroke, Cerebrovascular Accident, Hemiparesis
- Trial name
- NCT03645122
- Testing
- Paired corticospinal-motoneuronal stimulation (PCMS)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Postsurgical Pain
Study Evaluating the Safety, Efficacy and Pharmacokinetics of CA-008 (Vocacapsaicin)
In the pilot (Part A) of this study, multiple doses of CA-008 (vocacapsaicin) were evaluated for safety, tolerability, and PK. Doses were then selected for the expanded part (Part B) of the study, where CA-008 was compared to…
- Trial name
- NCT04203537
- Testing
- CA-008
- Where
- 4 sites in United States
- Volunteers
- 193 people
- Sponsor
- Concentric Analgesics
Pain
Exercise-induced Hypoalgesia After Comparative Forms of Exercise
The study involves recording response to discomfort following different forms of exercise. We think that there will be a increased pain tolerance following exercise but are unsure if there will be a difference between exercises.
- Trial name
- NCT01883895
- Testing
- Forgionei-Barber pressure-pain stimulator, Concentric Exercise, isometric exercise
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hip Arthroplasty
Effect of Spinal Ketorolac on Mechanical Hypersensitivity After a Total Hip Replacement
Chronic pain in patients following total hip replacement seems to be a significant problem. Previous research has shown that more effective pain management in the early postoperative period may decrease the incidence of the…
- Trial name
- NCT00621530
- Testing
- ketorolac tromethamine opthalmic solution
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Wake Forest University
Drug-resistant Epilepsy, Focal-Onset Seizures
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
The purpose of the study is to characterize the dose-response relationship with respect to efficacy of Padsevonil administered concomitantly with up to 3 anti-epileptic drugs (AEDs) for treatment of observable focal-onset…
- Trial name
- ARISE (NCT03373383)
- Testing
- Padsevonil
- Where
- 148 sites in United States, Australia and 17 more
- Volunteers
- 411 people
- Sponsor
- UCB Biopharma S.P.R.L.
Atherosclerotic Coronary Vascular Disease
Evaluation of Exercise Treadmill Test (ETT) Indices in Participants With Cardiovascular Disease
The study was designed to evaluate the use of ETT electrocardiogram (ECG) indices as biomarkers in the assessment of atherosclerotic coronary vascular disease (ASCVD).
- Trial name
- NCT01562041
- Testing
- Ranolazine 500 mg
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson's Disease, Levodopa
Erythromycin in Parkinson's Disease
Gastroparesis (slow stomach emptying) is a common feature of Parkinson's Disease. Levodopa (Sinemet), a common medication for Parkinson's Disease, can make gastroparesis worse.
- Trial name
- NCT02005029
- Testing
- Erythromycin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Malignant Glioma
Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas
The purpose of this study is to see if the addition of the investigation drug called pembrolizumab (Keytruda®) to radiation therapy and bevacizumab (Avastin®) is safe and can help with controlling the growth of tumors, in…
- Trial name
- NCT02313272
- Testing
- Hypofractionated Stereotactic Irradiation (HFSRT), Pembrolizumab, Bevacizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Psychoses, Substance-Induced
Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
Ketamine, an FDA approved anesthetic agent, is becoming the sedative/analgesic of choice for emergency sedation in children because it causes deep sedation with minimal respiratory depression in comparison to other available…
- Trial name
- NCT00205712
- Testing
- Ketamine, Dexmedetomidine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Obstructive Sleep Apnea, Tonsillitis
Pediatric Pain Optimization After Tonsillectomy
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery.
- Conditions
- Obstructive Sleep Apnea, Tonsillitis, Pain, Procedural
- Trial name
- NCT05244226
- Testing
- Fentanyl/Hydromorphone, Methadone
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Muscle Spasticity
Observational Study of Botox® Treatment for Patients With Upper Limb Adult Spasticity
This is a prospective, non-interventional, observational study to collect data on the use of botulinum toxin Type A in a routine setting in patients with upper limb adult spasticity.
- Trial name
- NCT01387074
- Testing
- botulinum toxin Type A
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Allergan
Apathy, Diabetes
The Role of Apathy in Glycemic Control
In spite of several new medications and insulins for the control of blood sugars in patients with diabetes, a large number of patients do not have good control.
- Trial name
- NCT00844090
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- US Department of Veterans Affairs
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose
The procurement of blood for SMBG, usually via a finger stick, is considered by many patients to be the most painful portion of diabetes therapy.
- Trial name
- NCT00741390
- Testing
- BD/33G, OTM / 33G, OTU/28G
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Becton, Dickinson and Company
Pain
Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy
The purpose of this study is to characterize the pharmacokinetic (PK) profile of a single dose of EXPAREL (133 mg/10 mL) administered intraoperatively per normal infiltration for prolonged analgesia in 12 adult subjects…
- Trial name
- NCT02199574
- Testing
- EXPAREL
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pain
Study To Evaluate Efficacy And Safety Of An Additional Dose Of Celecoxib (YM177) In Patients With Post-Tooth Extraction Pain
To evaluate efficacy and safety of additional dose of celecoxib, as compared to placebo, in patients with post lateral mandibular impacted third molar tooth extraction pain.
- Trial name
- NCT01062113
- Testing
- Celecoxib
- Where
- 22 sites in Japan
- Volunteers
- 255 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
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