Clinical trials: Neurological Condition
Behavioral Manifestations of Lesch-Nyhan Disease
Trial of Kuvan in Lesch-Nyhan Disease
To assess the possibility that treatment with Kuvan (a form of tetrahydrobiopterin) will lessen the abnormal behavior and/or neurology commonly found in Lesch-Nyhan disease (LND); to assess biochemical changes as measured in…
- Trial name
- NCT00935753
- Testing
- sapropterin
- Where
- United States
- Sponsor
- University of California, San Diego
Pain, Inflammation
Study of Experimental Models of Pain and Inflammation.
The experimental pain model studied in this proposal show characteristics of an inflamed wound with a pro-inflammatory response.
- Trial name
- NCT01097902
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Martin Angst
Acute Mountain Sickness, Blood Oxygen Saturation, Headache
Ibuprofen vs Acetaminophen for AMS Prevention
AMS (acute mountain sickness) affects those who ascend too high (>2000m) too fast. Acetazolamide is an effective drug for the prevention of AMS where proper acclimatization with gradual ascent may not be an option.
- Trial name
- NCT02244437
- Testing
- Ibuprofen, Acetaminophen
- Where
- Nepal
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Mountain Medicine Society of Nepal
Radiation Toxicity, Chemotherapeutic Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms, who have been referred to the HUGCDN Chronic Pain Unit for adjuvant palliative treatment with…
- Conditions
- Radiation Toxicity, Chemotherapeutic Toxicity, Chemotherapy-induced Peripheral Neuropathy, Delayed Wound Healing
- Trial name
- EPOOzo (NCT05417737)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Bernardino Clavo, MD, PhD
Pain, Acute, Congenital Heart Disease
Transverse Thoracic Plane Block in the Pediatric Cardiac Patient
Postoperative pain after cardiothoracic surgery can be a significant problem interfering with recovery, yet difficult to manage due to the sedating effects of opiates.
- Trial name
- TTPPCT (NCT04138745)
- Testing
- Transverse Thoracic Plane Block
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Pain
Efficacy of a Nurse Telephone Follow-up on Pain Intensity After Removal of Tonsils in Children
The purpose of this study is to determine if a nurse telephone follow-up to parents of children who underwent a removal of their tonsils would be effective in reducing pain intensity, complications and resort to other healthcare…
- Trial name
- NCT01568372
- Testing
- Telephone follow-up
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Tinnitus
Hearing Aids With "Notched Amplification" for the Treatment of Chronic Tinnitus
Pilot study on safety, tolerability and clinical performance/randomized double-blind active-controlled pilot-study. Patients are being recruited from patients of the Tinnitus Center of Regensburg and groupwise randomized.
- Trial name
- NoA-Tin (NCT02408575)
- Testing
- Notched filtering (verum)
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University of Regensburg
Head and Neck Neoplasms, Hearing Disorder
Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin Chemoradiation
Background: Cisplatin is a chemotherapy drug. It is used to treat head and neck squamous cell carcinoma (HNSCC) and other cancers. It can cause hearing loss for some people.
- Conditions
- Head and Neck Neoplasms, Hearing Disorder, Hyperlipidemia
- Trial name
- NCT03225157
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Pain
Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on Abdominal Hysterectomy Patients
The aim of this study is to investigate comparison of preemptive analgesic effects of dexketoprofen versus dexmedetomidine on the patients that is undergoing abdominal hysterectomy.
- Trial name
- NCT02092012
- Testing
- dexketoprofen trometamol, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Chronic Pain, Suicidal Ideation
Mindfulness for Pain and Suicide
The proposed study will assess the feasibility and acceptability of a mindfulness-based intervention to reduce functional impairment from chronic pain and risk of suicide.
- Conditions
- Chronic Pain, Suicidal Ideation, Suicide, Attempted, Opioid Use
- Trial name
- NCT05286112
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Health Education
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Canandaigua VA Medical Center
Hemifacial Spasm, Microvascular Decompression
Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery
There have been reports of monitoring LSR during MVD surgery helps predicting the clinical outcome of MVD. However, there have been no evidence of which degree of partial neuromuscular blockade should be performed during LSR…
- Conditions
- Hemifacial Spasm, Microvascular Decompression, Neuromuscular Blockade
- Trial name
- NCT01613781
- Testing
- TOF count-guided partial NMB, T1/Tc guided partial NMB
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Samsung Medical Center
Neurologic Manifestations, Psychiatric Disorders
Cohort of Patients With Covid-19 Presenting Neurological or Psychiatric Disorders (CoCo-Neurosciences)
Covid-19 pandemic now affects more than two million people worldwide. The neurotropism of the virus is assumed by its frequent association with neurological symptoms (anosmia, ageusia, headaches) but the extent of the central or…
- Conditions
- Neurologic Manifestations, Psychiatric Disorders, COVID-19
- Trial name
- CoCo-Neuro (NCT04362930)
- Where
- France
- Volunteers
- 730 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Registry
With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NDD Registry (NCT04472130)
- Where
- Hong Kong
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Vincent Mok
Spinal Cord Injury
Spinal Cord Injury Collaborative Care Study
The objective of this study is to test the effectiveness of a collaborative care approach to improving outpatient treatment for inactivity, chronic pain and depression as a way of improving overall Quality of Life for patients…
- Trial name
- SCI-Care (NCT02026167)
- Testing
- Collaborative Care
- Volunteers
- 174 people
- Sponsor
- University of Washington
Hearing Loss, Cognitive Impairment, Mild
ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life
Although previous studies indicated that tackling hearing loss may have a secondary benefit in improving cognitive function and delaying the onset of dementia, a more integrated care approach to optimize both hearing and…
- Trial name
- NCT06955494
- Testing
- Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- The University of Hong Kong
Quadratus Lumborum Block, Analgesia
Transversus Abdominis Plane Block Plus Quadratus Lumborum Block or Retrolaminar Block of Multiple Injections for Postoperative Analgesia Following Laparoscopic Colorectal Surgery
Our hypothesis was that transversus abdominis plane block plus retrolaminar block would reduce postoperative sufentanil consumption and provide superior analgesia compared with transversus abdominis plane block plus quadratus…
- Conditions
- Quadratus Lumborum Block, Analgesia, Laparoscopic, Colorectal
- Trial name
- NCT05416866
- Testing
- Retrolaminar block on the operative side, Quadratus lumborum block on the operative side, Transversus abdominis plane block on the nonoperative side
- Volunteers
- 100 people
- Sponsor
- dong zhang
ADHD
The Effects of Yoga on Attention, Impulsivity and Hyperactivity in Pre-school Age Children
This pilot project will evaluate yoga as an intervention to improve attention and reduce challenging behaviors such as hyperactivity and impulsivity, rated by parent and teachers, in preschool age children with or "at risk" for…
- Trial name
- NCT02642666
- Testing
- Children's Yoga
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Analgesia
Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following HTO/DFO/TTO
A randomized, single-blind, single-center study measuring the effects of adductor canal block combined with IPACK infiltration compared to adductor canal block alone on post-operative pain and opioid consumption in patients…
- Trial name
- NCT06952556
- Testing
- ACB, IPACK block
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Acute Pain
Ketamine Versus Morphine Change Pain Profile
The aim of this study is to evaluate the efficacy of intravenous low dose ketamine infusion versus morphine infusion analgesia for pain reduction in Abdominoplasty surgery
- Trial name
- NCT03664622
- Testing
- Ketamine, Morphine
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Cairo University
Fatigue Syndrome, Chronic
Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
Background: The way the brain processes rewards and punishments may play a role in some disorders of the nervous system. People with chronic overlapping pain conditions (such as myalgic encephalomyelitis/chronic fatigue syndrome…
- Trial name
- NCT06472622
- Testing
- Thermal Pain Stimulation, Physical Effort Stimulation
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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