Clinical trials: Neurological Disease
Myofascial Pain Syndromes, Low Back Pain
Radial Extracorporeal Shock Wave Treatment (rESWT) of Myofascial Pain Syndrome in Low Back Pain
The purpose of this study is to evaluate the efficacy of treatment of radial shockwave in myofascial pain syndrome in the lumbar region compared to placebo through questionnaires and imaging exams.
- Conditions
- Myofascial Pain Syndromes, Low Back Pain, Lumbago
- Trial name
- NCT01835795
- Testing
- Swiss DolorClast® CLASSIC applicator
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Musculoskeletal Pain
Transcultural Adaptation and Validation to Spanish of the OSPRO Questionnaires
Clinical guidelines for managing musculoskeletal pain recommend first, assessing and identifying any signs of severe physical conditions (i.e."red flags") and then, asessing the psychosocial prognostic factors of poor outcomes…
- Trial name
- SpanishOSPRO (NCT05869695)
- Testing
- OSPRO-ROS Questionnaire, OSPRO-YF Questionnaire
- Where
- 2 sites in Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Moyamoya Disease
Remimazolam Consumption: TCI vs. Manual Infusion
The purpose of this prospective randomized controlled trial is to compare the total consumption of remimazolam between two different administration methods-Target-Controlled Infusion (TCI) and manual infusion-in patients…
- Trial name
- NCT07377695
- Testing
- Target-Controlled Infusion (TCI) of Remimazolam, Manual Infusion of Remimazolam
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Stroke, Gait Disorders, Neurologic
High Vs Low Intensity Virtual Reality Gait Training in Individuals with Chronic Stroke
The purpose of this pilot study is to investigate the feasibility of 1) providing virtual reality walking training using a custom developed setup able to be replicated in routine clinical practice and 2) combining the virtual…
- Trial name
- NCT06522477
- Testing
- Virtual reality gait training
- Where
- United States
- Sponsor
- Indiana University
Intracerebral Hemorrhage
Edaravone Dexborneol for Treatment of Hypertensive Intracerebral Hemorrhage
pending
- Trial name
- ED-ICH (NCT04714177)
- Testing
- Edaravone Dexborneol
- Volunteers
- 390 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Subjective Sleep Quality, Objective Sleep Quality
Effect of B. Longum 1714™ on Sleep Quality
The aim of this study is to evaluate the effect of supplementation with the B. longum 1714™ strain on subjective and objective sleep quality in healthy participants.
- Trial name
- NCT04167475
- Testing
- Probiotic capsule
- Where
- Ireland
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- PrecisionBiotics Group Ltd.
Obstructive Sleep Apnea (OSA), Suspected Obstructive Sleep Apnea
Empirical CPAP Therapy for Suspected Obstructive Sleep Apnea in a Resource-Limited Setting
Obstructive sleep apnea (OSA) is a condition where a person's airway repeatedly collapses during sleep, causing them to stop breathing briefly and disrupting their rest.
- Conditions
- Obstructive Sleep Apnea (OSA), Suspected Obstructive Sleep Apnea, Sleep Apnea Syndromes
- Trial name
- NCT07693101
- Volunteers
- 80 people
- Sponsor
- Assiut University
Migraine Disorders
Patient Reported Outcomes in Patients With Chronic Migraine Treated With BOTOX®
This study will prospectively assess long term heath related quality of life in chronic migraine patients currently being treated with OnabotulinumtoxinA for injection (BOTOX®) as standard of care.
- Trial name
- PREDICT (NCT02502123)
- Testing
- No Intervention
- Where
- 15 sites in Canada
- Volunteers
- 215 people
- Sponsor
- Allergan
Wilson Disease
Study of ALXN1840 Versus Standard of Care in Pediatric Participants With Wilson Disease
This study is being conducted to evaluate the efficacy, safety, pharmacokinetics (PK), and pharmacodynamics of ALXN1840 versus standard of care in pediatric participants with Wilson disease (WD).
- Trial name
- NCT05047523
- Testing
- ALXN1840, Standard of Care
- Where
- 20 sites in Australia, France and 5 more
- Volunteers
- 40 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Diabetic Neuropathy
Vitamin D Treatment for Painful Diabetic Neuropathy
The main objective of the study is to assess the effect of vitamin D treatment on painful diabetic neuropathy in Pakistan. This is a prospective study of diabetic patients with a DN score ≥ 4, administered a single dose of…
- Trial name
- NCT02737423
- Testing
- cholecalciferol
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Baqai Institute of Diabetology and Endocrinology
Brain Injuries, Traumatic
CREACTIVE - Collaborative REsearch on ACute Traumatic Brain Injury in intensiVe Care Medicine in Europe
CREACTIVE is a large-scale observational cohort study concerning Traumatic Brain Injury (TBI) care in the ICU setting
- Trial name
- CREACTIVE (NCT02004080)
- Testing
- Intensive Care treatment
- Where
- 20 sites in Italy
- Volunteers
- 8,000 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Acoustic Schwannoma, Adult Anaplastic Meningioma
Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Conditions
- Acoustic Schwannoma, Adult Anaplastic Meningioma, Adult Ependymoma, Adult Grade I Meningioma
- Trial name
- NCT01125046
- Testing
- bevacizumab
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northwestern University
Parkinson Disease, Neurodegenerative Diseases
Mobile Parkinson Observatory for Worldwide, Evidence-based Research (mPower)
The purpose of this study is to understand variation in the symptoms of Parkinson disease. This study uses an iPhone app to record these symptoms through questionnaires and sensors.
- Conditions
- Parkinson Disease, Neurodegenerative Diseases, Movement Disorders, Central Nervous System Diseases
- Trial name
- mPower (NCT02696603)
- Testing
- Participant self-assessment surveys, Phonation, Gait and balance
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sage Bionetworks
Stroke
Perturbation Training for Fall-risk Reduction Among Stroke Survivors
The long-term objective of this research is to develop an efficacious training paradigm to enhance stroke survivors' defense mechanisms against falls and possibly reduce healthcare cost.
- Trial name
- NCT03205527
- Testing
- Overground slip perturbation training
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of Illinois Chicago
Chronic Fatigue Syndrome
Pacing Activity Self-management for Patients With Chronic Fatigue Syndrome
Given the lack of evidence in support of pacing self-management for patients with chronic fatigue syndrome (CFS), it is examined whether physical behavior and health status of patients with CFS improve in response to a pacing…
- Trial name
- NCT01512342
- Testing
- Pacing, relaxation therapy
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- Vrije Universiteit Brussel
Angina Patients With Non-obstructive Coronary Artery Disease
Exercise Therapy for Women With ANOCA
Angina is a feeling of chest pain or discomfort which can happen if there is reduced blood flow to the heart. Patients can experience angina with no obstructive coronary arteries (ANOCA) which is a difficult condition to treat…
- Trial name
- ANOCA Exercise (NCT07733986)
- Testing
- Resistance based exercise
- Where
- 11 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- NHS Greater Glasgow and Clyde
Traumatic Brain Injury
Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells
The purpose of this study is to determine if bone marrow harvest, BMMNC separation, and re-infusion in adults with acute severe TBI is safe and will improve functional outcome.
- Trial name
- NCT01575470
- Testing
- autologous bone marrow mononuclear cells
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center, Houston
Sleep Quality
Understanding Physiology During Float-REST and the Consequential Effects on Subjective and Objective Recovery
The objective of this research study is to assess how the implementation of various modern strategies for augmented recovery and physiological monitoring via wearable biotechnologies and subjective measurements affect sleep…
- Trial name
- NCT04415970
- Testing
- Flotation therapy sensory deprivation tank, Sleep Pod
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Plantar Fasciitis of Both Feet, Metatarsalgia
A Test of Efficacy and Foot Position Alteration in Patients Wearing Good Feet Arch Supports for the Treatment of Pain
This study is a single armed prospective case series designed to evaluate the efficacy of treating common structural-related foot ailments (i.e.
- Conditions
- Plantar Fasciitis of Both Feet, Metatarsalgia, Morton Neuroma, Hallux Valgus Deformity
- Trial name
- Good Feet (NCT07103070)
- Testing
- Arch supports
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Massachusetts General Hospital
Analgesia, Anesthesia
Analgesic Depth Evaluation During General Anesthesia With Dexmedetomidine-remifentanil Infusion. A Pilot Study
The aim of this study is to verify the feasibility of an evaluation of the depth of analgesia during an opioid sparing anesthesia (OSA) carried out with continuous infusion of dexmedetomidine in addition to general multimodal…
- Trial name
- NCT05785273
- Testing
- Pupillometer
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Università degli Studi di Brescia
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