Clinical trials: Neurological Disease
Obstructive Sleep Apnea, Snoring
Novel Myofunctional Water Bottle to Reduce OSA and Snoring Study
This research study is being done to determine whether the repetition and resistance from the daily use of the myofunctional therapy (MT) nozzle will improve obstructive sleep apnea and primary snoring.
- Trial name
- NCT05371509
- Testing
- Myofunctional therapy (MT) nozzle
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Gastroparesis
Study of Tadalafil for the Treatment of Diabetic Patients With Symptoms of Upset Stomach and Delayed Stomach Emptying
The purposes of this study are to determine whether an experimental drug known as tadalafil can reduce symptoms of dyspepsia (fullness after eating, inability to finish a regular meal, bloating, discomfort or pain in the upper…
- Trial name
- NCT00050609
- Testing
- tadalafil
- Where
- 12 sites in Canada
- Volunteers
- 2 people
- Sponsor
- Eli Lilly and Company
Bacterial Meningitis
Vitamin d Levels in Children With Bacterial Meningitis
The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.
- Trial name
- NCT02467309
- Volunteers
- 50 people
- Sponsor
- Gang Liu
Temporomandibular Disorders (TMDs), Kinesiophobia
The Italian Version of the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD)
This observational, cross-sectional study aims to translate, culturally adapt, and psychometrically validate the Italian version of the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD-ITA).
- Trial name
- TSK-TMD-ITA (NCT07750509)
- Volunteers
- 250 people
- Sponsor
- Alessandro Aquino
Dementia, Alzheimer Type
A Phase II Study to Assess the Safety, Tolerability and Efficacy of Xanamem™ in Subjects With Mild Dementia Due to AD (XanADu)
This XanADu Phase II study in mild Alzheimer's Disease (AD) is to assess the safety, tolerability and efficacy of Xanamem in subjects with mild dementia due to Alzheimer's Disease.
- Trial name
- XanADu (NCT02727699)
- Testing
- Xanamem™
- Where
- 25 sites in United States, Australia and 1 more
- Volunteers
- 185 people
- Sponsor
- Actinogen Medical
Alzheimer Disease, Mild Cognitive Impairment
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or…
- Trial name
- NCT05904132
- Testing
- tACS device
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Mini-Mental State Examination
Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients
This study looks at people with Alzheimer's disease to find out which factors are linked to their initial score on the Mini-Mental State Examination (MMSE) and which factors may predict a fast decline in their score over 12…
- Conditions
- Alzheimer Disease, Mini-Mental State Examination, Cognitive Dysfunction, Neuropsychological Tests
- Trial name
- NCT07122856
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier de Gonesse
Post-Operative Confusion
High Spinal Anesthesia and the Incidence of Delirium After Cardiac Surgery
This is a feasibility study to determine if enough patients undergoing elective or urgent cardiac surgery, can be enrolled in a study where patients are randomized to receive high spinal anesthesia as an adjunct to general…
- Trial name
- NCT05374356
- Testing
- Intrathecal bupivacaine and morphine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Depression, Stroke
Yoga Exercise for Improving Balance in Patients With Subacute &Ｃhronic Stroke
Hypothesis: This study investigated the hypothesis that subacute and chronic stroke patients who received a combination of yoga and traditional physiotherapy were getting more improvement in standing balance than traditional…
- Trial name
- NCT01806922
- Testing
- Yoga
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Disorders of Consciousness Due to Severe Brain Injury
Prognostication of Recovery in Early Disorders of Consciousness Study
By collecting multimodal metrics (e.g., clinical factors, neuroimaging, and EEG) in the early phase of severe brain injury (i.e., during the acute hospitalization when a patient has impaired consciousness), and measuring the…
- Trial name
- PREDICT (NCT04692922)
- Testing
- MRI, EEG
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Infant, Premature, Erythropoietin
High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study
The highest risk for perinatal brain injury occurs among extremely premature infants who weigh less than 1250 grams at birth. Such perinatal brain injury is currently irreversible, associated with neurodevelopmental disability…
- Conditions
- Infant, Premature, Erythropoietin, Brain Injury, Intraventricular Hemorrhage
- Trial name
- NCT00589953
- Testing
- Erythropoietin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Impulse Control Disorder, Parkinson Disease
Naltrexone for Impulse Control Disorders in Parkinson's Disease
This study will evaluate the effectiveness of naltrexone in reducing ICD symptoms in Parkinson's disease patients taking a dopamine agonist.
- Trial name
- NCT01052831
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Spatial Neglect, Hemispatial Neglect
A Model to Identify Specific Predictors of Spatial Neglect Recovery
This study examines methods to better predict improvement of a hidden disability of functional vision, spatial neglect, following stroke.
- Conditions
- Spatial Neglect, Hemispatial Neglect, Hemineglect, Unilateral Neglect
- Trial name
- NCT00990353
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Kessler Foundation
Deep Venous Thrombosis, Pulmonary Embolism
Drug Interaction Between Paracetamol and Warfarin
The objective of this study is to investigate whether paracetamol, given at therapeutic doses (2g/day and 3 g/day), may potentiate the anticoagulant effect of warfarin.
- Conditions
- Deep Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Stroke
- Trial name
- INPAWA2 (NCT01104337)
- Testing
- paracetamol
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Hopital Lariboisière
Tension-Type Headache
Effectiveness of Vagus Nerve Stimulation in Individuals With Tension-Type Headache
It is planned to examine the effect of Vagus Nerve Stimulation on headache symptoms in individuals with tension-type headache.
- Trial name
- NCT06604637
- Testing
- Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bitlis Eren University
Fragile X Syndrome
Study of SPG601 in Adult Men With Fragile X Syndrome
This Phase 2 study described herein will evaluate the safety, efficacy, tolerability, pharmacokinetics and pharmacodynamics of SPG601 in adult men with Fragile X syndrome.
- Trial name
- NCT06413537
- Testing
- SPG601
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Spinogenix
Insomnia
A Clinical Study to Evaluate the Pharmacokinetic Profile of SB-649868 in Elderly and Female Population
The purpose of this study is to determine the blood levels and the tolerability of SB-649868 in Elderly and Female population
- Trial name
- NCT00534872
- Testing
- SB-649868
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Recurrent Tonsillitis, Peritonsillar Abscess
Auricular Acupuncture for The Treatment of Post-Tonsillectomy Pain
The goal of this study is to assess the role of battlefield acupuncture in the reduction of pain scores status post adult tonsillectomy.
- Conditions
- Recurrent Tonsillitis, Peritonsillar Abscess, Obstructive Sleep Apnea
- Trial name
- NCT01790477
- Testing
- Auricular Acupuncture
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Myofascial Pain Syndrome - Neck, Spondyloarthrosis
Can Blood Biomarkers of Inflammation and BDNF be Used to Assess the Effectiveness of Collagen Mesotherapy in Chronic CMPS?
The aim of the study is to assess the concentration of anti-inflammatory markers after the use of cervical spine mesotherapy in the course of pain syndrome. The study is randomized.
- Conditions
- Myofascial Pain Syndrome - Neck, Spondyloarthrosis, Neck Pain, Cervical Pain
- Trial name
- NCT06807177
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
Brain and Central Nervous System Tumors
Paclitaxel Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00031577
- Testing
- paclitaxel, radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Children's Hospital of Philadelphia
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