Clinical trials: Neurological Disease
Amyotrophic Lateral Sclerosis
Repetitive Transcranial Magnetic Stimulation as Therapy for Depression in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of central and peripheral motor neurons. ALS leads to death usually within 3 to 5 years from the onset of the symptoms.
- Trial name
- NCT03892863
- Testing
- active repetitive transcranial magnetic stimulation
- Where
- Poland
- Sponsor
- Jagiellonian University
Cardiac Amyloidosis
Echocardiographic Characterization of Cardiac Amyloidosis
This is a mono-center observational ambispective study in which patients with cardiac amyloidosis evaluated at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Rome, Italy) will be enrolled.
- Trial name
- Echo-AMY (NCT05760287)
- Where
- Italy
- Volunteers
- 255 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Optic Neuritis, Multiple Sclerosis
Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)
3D FLAIR, 3D T1 FAT SAT, coronal T2 and coronal T1 dixon sequences were usually used to assess visual deficits in MRI. Optic nerve examination is preferably performed using a coronal T2 sequence in order to detect a hypersignal…
- Trial name
- COCON (NCT04793087)
- Testing
- Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Hydrocephalus, Normal Pressure
Diagnostic Accuracy of ShuntCheck Compared to Radionuclide Shunt: Patency in Patients With Normal Pressure Hydrocephalus
The purpose of this study is to assess the diagnostic accuracy of ShuntCheck compared with radionuclide shunt patency testing (SPS) to detect CSF shunt flow of NPH patients with suspected shunt obstruction.
- Trial name
- NCT04309487
- Testing
- ShuntCheck
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of South Florida
Parkinson Disease
Evaluation of the Efficacy and Safety of Fecal Microbiota Transplantation for Constipation in Parkinson's Disease
Participants will be allocated to FMT group or placebo group at a 1:1 ratio. For interventional group, patients will be given six FMT capsules twice a week for 24 weeks.
- Trial name
- NCT06388863
- Testing
- Healthy donor-derived FMT capsule
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Parkinson Disease
Effect of Multimodal Exercise Training on Walking Economy in Individuals With Parkinson's Disease
Sustained ambulation is a challenge for individuals with Parkinson's disease (PD) as walking economy is frequently compromised. There are also various disease-related skeletal muscle alterations that may contribute to performance…
- Trial name
- NCT03864393
- Testing
- Multimodal overground locomotor training
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- George Mason University
Idiopathic Parkinson's Disease
Dopamine Effect on Inhibitory Control
The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications.
- Trial name
- DEI (NCT03665493)
- Testing
- PD patients H&Y=1.5-2 Medications ON, PD patients H&Y=1.5-2 Medications OFF, Healthy age-matched controls
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giovanni Mirabella
Adult Women
Interoceptive Awareness and Dream Themes
Individual differences in reported dream themes may reflect not only waking emotional and cognitive experiences but also characteristic ways of attending to, interpreting, and regulating bodily signals.
- Trial name
- NCT07716514
- Where
- Turkey (Türkiye)
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Carpal Tunnel Syndrome
Comparison of Efficacy Between Conservative Versus Operative Management of Carpel Tunnel Syndrome
Patients presented with symptoms of numbness at night, pain, or tingling sensation in the fingers particularly at night diagnosed by consultant orthopedic surgeon on physical examination.
- Trial name
- NCT06060314
- Testing
- Conservative Approach, Surgical Approach
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Combined Military Hospital Abbottabad
Insomnia, Insomnia Chronic
Efficacy and Safety of APSTZD in the Treatment of Insomnia Disorder
The purpose of this study is to evaluate the efficacy of APSTZD compared to one active drug and placebo in insomnia treatment.
- Trial name
- TINA (NCT07420816)
- Testing
- APSTZD 1, APSTZD 2, APSTZD 3
- Where
- Brazil
- Volunteers
- 222 people
- Sponsor
- Apsen Farmaceutica S.A.
Hypotension, Consciousness, Level Altered
The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients
Unexpected deaths and unplanned intensive care unit (ICU) admissions are common during hospital stay and are often preceded by warning abnormalities in patients' vital signs.
- Conditions
- Hypotension, Consciousness, Level Altered, Airway Disease, Respiratory Failure
- Trial name
- SPHERE (NCT06503016)
- Testing
- Phosphocreatine
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Università Vita-Salute San Raffaele
Chronic Migraine, Medication Overuse Headache
Non-Invasive Brain Stimulation as Add-on Treatment in Chronic Migraine With Medication Overuse
This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy of non-invasive brain stimulation as an add-on treatment to standard detoxification therapy in patients with chronic migraine and…
- Trial name
- NCT07442916
- Testing
- Active rTMS Motor Cortex Face, Active rTMS - Motor Cortex Forearm
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Fibromyalgia
Tailored Cognitive-Behavioral Therapy for Fibromyalgia Patients at Risk
The present study is a new approach of examining tailored cognitive-behavioral interventions for fibromyalgia patients at risk. For this purpose, fibromyalgia patients are screened with respect to cognitive-behavioral risk…
- Trial name
- NCT00268606
- Testing
- cognitive-behavioral therapy
- Where
- 5 sites in Netherlands
- Volunteers
- 400 people
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Post Traumatic Stress Disorder
Characterization of Olfactory Perception in Post-Traumatic Stress Disorder
The core symptoms of post-traumatic stress disorder (PTSD) include flash backs, intrusive pictures and thoughts related to the traumatic event, hyperalertness, avoidance of traumatic relevant environmental triggers and emotional…
- Trial name
- TRAUMODO (NCT06494306)
- Testing
- European Test of Olfactory Capabilities (ETOC), Standardized Hedonicity Test, Questionnaires
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Migraine
Migraine Induction Properties of PACAP-38 After Eptinezumab in Migraine Without Aura Patients.
To investigate whether administration of calcitonin gene-related peptide (CGRP) binding monoclonal antibodies eptinezumab prevents pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) induced migraine attacks in…
- Trial name
- NCT05635604
- Testing
- Eptinezumab, PACAP-38
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Danish Headache Center
Migraine, Cluster Headache
Context-awareness, Physiological Monitoring, and Machine Learning in Migraine and Cluster Headache
This is an observational, longitudinal cohort pilot study measuring physiological signals through wearable sensors combined with machine learning algorithms to detect behaviour, stress and headaches in patients with migraine and…
- Trial name
- COPIMAC (NCT04949204)
- Testing
- Wearable sensor detection
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University Hospital, Ghent
Bladder, Overactive, Parkinson Disease
Effect of Medical Cannabis for Non-motor Symptoms of Parkinson's Disease
Medical cannabis (MC) is a standard treatment in Israel to Parkinson's disease (PD) patients suffering from pain. Nevertheless, it is not known about MC effectiveness for other non-motor symptoms of the disease.
- Trial name
- NCT05106504
- Testing
- Medical Cannabis
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Brain Tumor, Recurrent, Brain Tumor
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
The objectives of this registry study are to evaluate real-world clinical outcomes and patient reported outcomes that measure the effectiveness and safety of STaRT.
- Conditions
- Brain Tumor, Recurrent, Brain Tumor, Brain Tumor, Primary, Brain Tumor - Metastatic
- Trial name
- NCT04427384
- Testing
- GammaTile
- Where
- 54 sites in United States
- Volunteers
- 600 people
- Sponsor
- GT Medical Technologies, Inc.
Glioblastoma
Key Longitudinal Associations With Risk and Glioblastoma Outcomes
The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.
- Trial name
- Key LARGO (NCT06625684)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Primary Insomnia
A High Density EEG Comparison of Sleep Patterns in Insomnia
Insomnia, defined as a subjective report of difficulty initiating sleep, maintaining sleep, and/or non-restorative sleep, leads to significant daytime dysfunction and increased health risks.
- Trial name
- NCT01960452
- Testing
- Serial awakenings
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
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