Clinical trials: Neurological Impairment
Osteoarthritis, Knee, Quality of Life
Yoga for Managing Knee Osteoarthritis in Older Women: a Feasibility Study
The study hypothesized that it is feasible and safe to use Hatha yoga in older women with knee osteoarthritis (OA), and practicing Hatha yoga regularly will help reduce pain and stiffness, enhance physical function, and improve…
- Conditions
- Osteoarthritis, Knee, Quality of Life, Poor Quality Sleep, Physical Impairment
- Trial name
- NCT01832155
- Testing
- Hatha yoga
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Prediabetes
Metformin and Muscle in Insulin-resistant Older Veterans
Sarcopenia is the loss of muscle mass, strength and function with aging and is associated with increased disability, falls and fractures.
- Trial name
- M&M (NCT01804049)
- Testing
- metformin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
LIFUP for Treatment of Motor Deficits in Parkinson's Disease
The study will test the feasibility of using Low Intensity Focused Ultrasound Pulsation (LIFUP) to treat motor symptoms in Parkinson's Disease (PD).
- Trial name
- LIFUP PD (NCT04593875)
- Testing
- Active LIFUP Treatment
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of California, Los Angeles
Central Retinal Vein Occlusion
Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Central Retinal Vein Occlusion (CRVO)
Provide efficacy and safety data on intravitreal injections of ranibizumab 0.5 mg in patients with visual impairment due to macular edema secondary to CRVO
- Trial name
- Camellia (NCT01976312)
- Testing
- Ranibizumab 0.5 mg
- Where
- 34 sites in China, Hong Kong and 5 more
- Volunteers
- 252 people
- Sponsor
- Novartis Pharmaceuticals
Blindness, Spinal Cord Injury
Use of "Smart Wheelchairs" to Provide Independent Mobility to Visual and Mobility Impairments
The goal of this project is to evaluate the Smart Wheelchair Component System (SWCS) for power wheelchairs and the Smart Power Assistance Module (SPAM) for manual wheelchairs in realistic indoor environments with target users…
- Trial name
- NCT00333762
- Testing
- Smart Power Assistance Module (SPAM), Smart Wheelchair Component System (SWCS)
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Amnestic Mild Cognitive Impairment, Alzheimer's Disease
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)
An urgent need exists to find effective treatments for Alzheimer's disease (AD) that can arrest or reverse the disease at its earliest stages.
- Trial name
- NCT01767909
- Testing
- Insulin (Humulin® R U-100)
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Southern California
Hearing Loss, Emergency Service
Hearing Impairment, Strategies, and Outcomes in Emergency Departments
Aim 1: Establish the feasibility of screening for hearing loss in the ED Aim 2: Determine the acceptability of the screening procedure (among the ED population) Aim 3: Derive a preliminary estimate of the effect size of primary…
- Conditions
- Hearing Loss, Emergency Service, Hospital Readmission
- Trial name
- Hear-VA (NCT03594500)
- Testing
- PockeTalker, No PockeTalker
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- VA Office of Research and Development
Alzheimer's Disease, Vascular Dementia
Effect of Insulin Sensitizer Metformin on AD Biomarkers
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and other cognitive functions.
- Conditions
- Alzheimer's Disease, Vascular Dementia, Dementia, Memory Impairment
- Trial name
- NCT01965756
- Testing
- Metformin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Low Vision, Orientation
SmartHMD for Improved Mobility
The National Eye Institute estimated about 3 million people over age 40 in the US had low vision in 2010 and projects an increase to nearly 5 million in 2030 and 9 million in 2050.
- Conditions
- Low Vision, Orientation, Mobility Limitation, Navigation, Spatial
- Trial name
- NCT03781583
- Testing
- SmartHMD version 1, SmartHMD version 2, SmartHMD version 3
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- James Weiland
Neurologic Disorder, Chronic Disease
Parent-Reported Symptom Assessments in Children Taking Multiple Medications
This study plans to learn about how to measure symptoms (like tiredness or rash) in children with special healthcare needs who take 5 or more medications. Sometimes symptoms change in severity over time or new symptoms develop.
- Conditions
- Neurologic Disorder, Chronic Disease, Pediatric Disorder
- Trial name
- PRSA (NCT03849066)
- Testing
- Parent-Reported Symptom Assessment
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Colorado, Denver
Hearing Impairment, Hearing Aid Fitting
Blast Exposed Veterans With Auditory Complaints
The purpose of this study is to study blast-exposed Veterans who report hearing handicap but show normal or near normal results on standard audiometric testing.
- Trial name
- NCT02122458
- Testing
- mild-gain hearing aids with high-frequency emphasis over 6-months
- Where
- 3 sites in United States
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Developmental Language Disorder, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder, Specific Language Impairment, Language Development
- Trial name
- NCT05325333
- Testing
- Retrieval-based word learning: Expanding retrieval practice schedule, Retrieval-based word learning: Standard retrieval practice schedule
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Purdue University
Mild Cognitive Impairment
Water-based Activity to Enhance Recall in Veterans
This two-year study will evaluate the feasibility of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI).
- Trial name
- WATER-VET (NCT02614092)
- Testing
- Water-based Activity + Cognitive Training
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alzheimers Disease, Postoperative Delirium
Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care
This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal…
- Conditions
- Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
- Trial name
- MADCO-PC (NCT01993836)
- Testing
- Total intravenous anesthesia with propofol, General anesthesia with isoflurane
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Duke University
Hearing Impairment
Evaluation of Carina Microphone Sensitivity and Maximum Stable Gain in Adult Recipients
This investigation is a single-centre, prospective, single-arm, post-market, non-interventional, pilot clinical investigation designed to characterize microphone sensitivity and maximum stable gain of the Cochlear Carina System.
- Trial name
- CAMSEN (NCT04271761)
- Testing
- Non-interventional, post-market, pilot study of Carina Cochlear System
- Where
- Portugal
- Volunteers
- 14 people
- Sponsor
- Cochlear
Amyotrophic Lateral Sclerosis
Efficacy and Safety of Plasma Exchange With Albumin in Patients With Amyotrophic Lateral Sclerosis
Pilot, phase II, prospective, open-label, uncontrolled study of plasma exchange with 5% albumin in 10 subjects having a definite, possible, or probable diagnosis of Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT02479802
- Testing
- Albumin
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Instituto Grifols, S.A.
Diabetic Macular Edema, Visual Impairment
A 12-month, Randomized, Efficacy and Safety Study of 0.5 mg Ranibizumab vs Laser in Chinese Diabetic Macular Edema (DME) Patients
Study of efficacy and safety of 0.5 mg ranibizumab in Chinese patients with diabetic macular edema (DME)
- Trial name
- REFINE (NCT02259088)
- Testing
- Ranibizumab (RFB002), Laser
- Where
- 28 sites in China
- Volunteers
- 384 people
- Sponsor
- Novartis Pharmaceuticals
Branch Retinal Vein Occlusion
Efficacy and Safety of Ranibizumab With or Without Laser in Comparison to Laser in Branch Retinal Vein Occlusion
This study will generate comparative data for 0.5-mg ranibizumab using PRN dosing administered with or without adjunctive laser treatment versus laser photocoagulation (the current standard of care) up to Month 6 in patients with…
- Trial name
- BRIGHTER (NCT01599650)
- Testing
- Ranibizumab, Laser
- Where
- 82 sites in Australia, Canada and 15 more
- Volunteers
- 455 people
- Sponsor
- Novartis Pharmaceuticals
Scotoma, Central, Central Visual Impairment
Visuomotor Rehabilitation Training for Manual Task Deficits From Macular Scotomas
The research is aimed at developing and testing a new method of visual-motor rehabilitation of Veterans with macular degeneration by using inexpensive "tablet" computers at home.
- Trial name
- VRT (NCT01691027)
- Testing
- Visuo-motor training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Macular Degeneration
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD)
This study is a phase III, double-masked, randomized, study of the efficacy and safety of VEGF Trap-Eye in patients with neovascular age-related macular degeneration.
- Trial name
- VIEW 2 (NCT00637377)
- Testing
- Ranibizumab, Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321)
- Where
- 189 sites in Argentina, Australia and 24 more
- Volunteers
- 1,240 people
- Sponsor
- Bayer