Clinical trials: Neurological Outcome
Subarachnoid Hemorrhage, Critical Illness
Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage
Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients.
- Conditions
- Subarachnoid Hemorrhage, Critical Illness, Infusion Fluid, Sodium Disorder
- Trial name
- CRYSTALLBrain (NCT04043598)
- Testing
- 0.9% Sodium-chloride, Ringer's Lactate
- Where
- 3 sites in Switzerland
- Volunteers
- 320 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pain Management, Quality of Life
Neuroma-Associated Pain Management After Combat-Related Trauma in Ukraine
This multicenter interventional study in Ukraine is designed to compare the effectiveness of cryoablation and radiofrequency ablation in managing neuroma-associated pain following combat-related trauma.
- Conditions
- Pain Management, Quality of Life, Neuroma, Functional Outcome
- Trial name
- NAP-C/R (NCT07416448)
- Testing
- cryoablation, Radiofrequency ablation alone
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc
The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
The purpose of this study is to compare changes in spinal stiffness and back muscle activity between spinal manipulative therapy (SMT) responders, non-responders and asymptomatic participants.
- Conditions
- Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc, Muscle Weakness, Spine Stiffness
- Trial name
- NCT01761838
- Testing
- SMT for low back pain patients, Pain induction (optional), Low back pain participants without SMT
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Macular Edema, Cystoid, Vision Disorders
Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant, (Ozurdex®) in improving outcome of cataract surgery in patients with diabetic macular edema.
- Conditions
- Macular Edema, Cystoid, Vision Disorders, Diabetic Macular Edema, Cystoid Macular Edema Following Cataract Surgery
- Trial name
- NCT01546402
- Testing
- Dexamethasone Drug delivery system (Ozurdex), Cataract surgery
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Aphasia
The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome
Combined analysis of functional and structural language network changes may be a good model for predicting language outcome.
- Trial name
- NCT03475745
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Carotid Stenosis, Postoperative Cognitive Dysfunction
Neurocognitive Function After Carotid Thrombendarterectomy
Previous studies did not reach a consensus on the influence of the type of anesthesiologic procedure and monitoring, during carotid thrombendarterectomy, on perioperative complications and cognitive outcomes.
- Conditions
- Carotid Stenosis, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT05739357
- Testing
- NIRS, EEG
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Ischemic Stroke
Effect of Acetaminophen on Neurological Outcome in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment
Neuro-inflammation response plays an important role in the development of acute ischemic stroke(AIS). The aim of this study was to conduct a prospective randomized controlled study on the effect of acetaminophen on long-term…
- Trial name
- ACEAIS (NCT06767969)
- Testing
- Acetaminophen
- Volunteers
- 892 people
- Sponsor
- Beijing Tiantan Hospital
Brain Death
Brain Death: Inflammatory Response, Apoptosis, and Endotoxin Tolerance
We hypothesized that brain death is associated with an early systemic inflammatory response, possibly combined with activation of apoptotic cell death, two events that may contribute to induce rapid organ dysfunction.
- Trial name
- NCT00615225
- Testing
- Muscle biopsy
- Where
- 3 sites in Belgium, France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Delafontaine Hospital
Status Epilepticus
EEG Monitoring for Refractory Status Epilepticus
This is a prospective randomized study to investigate the yield of continuous electroencephalogram (cEEG), as a diagnostic tool in intensive care unit (ICU), for patients with refractory status epilepticus (RSE) and the…
- Trial name
- NCT04170491
- Testing
- Continuous EEG
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Barts & The London NHS Trust
Brain Damage
Transcranial Doppler and Quantitative Pupillometry as Neurological Prognostic Factors in Brain Damaged Patients Admitted to Intensive Care Unit
Transcranial Doppler is performed daily in Intensive Care Unit in brain damaged patients. For a few years now, the measurement of the photomotor reflex by quantitative Pupillometry has been routinely performed in Intensive Care…
- Trial name
- NCT04846738
- Testing
- Transcranial Doppler, Pupillometry.
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Stroke
Long Term Outcome After Hemorrhagic Stroke Surgery
The investigators retrospectively reviewed all patients with neurosurgical operations for hemorrhagic stroke (intracerebral hemorrhage) between 1999 and 2008.
- Trial name
- NCT01409252
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Chinese University of Hong Kong
Low Back Pain
Back Pain - Linking Phenotype to Pain Mechanism and Outcome.
To investigate whether different clinical, psychophysical and neurophysiological phenotypes can be identified among low back pain patients
- Trial name
- NCT04433299
- Testing
- no intervention, observational
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Delirium, Cerebral Infarction
the Incidence and the Association Between Motor Subtypes and Outcome of Delirium in Ischemic Stroke Patients
this study examines the incidence of newly developed delirium in patients who admit to university hospital stroke unit for cerebral infarction, and analyze the association between delirium motor subtypes and short-term outcome in…
- Trial name
- NCT03317106
- Where
- South Korea
- Volunteers
- 943 people
- Sponsor
- Chungnam National University Hospital
Cardiac Arrest
Proteomics to Identify Prognostic Markers After CPR and to Estimate Neurological Outcome
Proteomics is used to identify prognostic markers after CPR. Additionally neurological outcome should be estimated by specific protein alterations and affections of pathways.
- Trial name
- NCT02247947
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Köln
Brain Injury
Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury
The purpose of this study is to test the drug apomorphine in subjects who are in a Vegetative State or a Minimally Conscious State.
- Trial name
- NH001-2 (NCT00761228)
- Testing
- Apomorphine
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- NeuroHealing Pharmaceuticals Inc.
Liver Cirrhosis, Refractory Ascites in Patients With Cirrhosis
Role of Nutritional Intervention for the Treatment of Sarcopenia in Cirrhotic Patients With Refractory Ascites Candidate to Transjugular Intrahepatic Portosystemic Shunt Placement and Identification of Prognostic Factors Related to Clinical Outcome
The hypothesis is that in patients with cirrhosis and refractory ascites candidate to TIPS, and sarcopenia (identified by a PMA ≤16 cm² at the level of L3), who are at high-risk of 6-month mortality after TIPS placement, a…
- Conditions
- Liver Cirrhosis, Refractory Ascites in Patients With Cirrhosis, Sarcopenia in Liver Cirrhosis
- Trial name
- NS-TIPS (NCT06814626)
- Testing
- 12-week nutritional intervention with Friliver dispensing, 12-week nutritional intervention with personalized diet, 12-week nutritional intervention with diet diary to report foods eaten.
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 72 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Delirium and Post-operative Cognitive Dysfunction (POCD)
Cognitive Outcome After Two-stage Liver-Operation
Cognitive outcome (delirium and post-operative cognitive deficiency) in patients undergoing two-time liver resection.
- Trial name
- 2-StaLi (NCT01809782)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Delirium, Stress Disorders, Post-Traumatic
Sedation Influence on Delirium and Post-traumatic Stress-disorder as a Result of Hospitalization in Intensive Care
The aim of this study is to investigate if sedation of Intensive Care Unit (ICU) patients influences the development of delirium during their ICU stay and if incidences of delirium have an impact on the development of…
- Trial name
- NCT01291368
- Where
- 2 sites in Denmark
- Volunteers
- 248 people
- Sponsor
- University of Aarhus
Patient Reported Outcomes, Long Term Outcomes
Patient-reported Outcome After Status Epilepticus
Status epilepticus (SE) is a common life-threatening neurological emergency in which prolonged or multiple closely spaced seizures can result in long-term impairments.
- Conditions
- Patient Reported Outcomes, Long Term Outcomes, Status Epilepticus, Intensive Care Unit
- Trial name
- POSEIDON (NCT05491590)
- Where
- 16 sites in France
- Volunteers
- 66 people
- Sponsor
- Versailles Hospital
Uveitis
Clinical Outcome in Uveitis
This study is aimed at investigating the long term clinical outcome of patients with uveitis.
- Trial name
- NCT01983488
- Where
- United Kingdom
- Volunteers
- 231 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust