Clinical trials: Neurological Outcome
Seizures, Epilepsy
Exercise Education for Adults With Seizure Disorders
Study Population -People with seizures benefit from regular exercise. Exercise may help decrease the number of seizures they have. It also improves overall health and quality of life.
- Trial name
- NCT01856335
- Testing
- Patient Education, exercise: increase physical activity/goal setting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Postoperative Delirium, Postoperative Cognitive Dysfunction
Cognitive Outcome After Surgical and Transcatheter Aortic Valve Replacement
Aortic valve stenosis is one of the most common types of heart disease in the aging Western population. While surgical cardiac valve replacement (SAVR) is a standard therapy for patients with aortic stenosis, catheter-assisted…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Transcatheter Aortic Valve Replacement, Surgical Aortic Valve Replacement
- Trial name
- COSTA (NCT04535076)
- Testing
- Transcatheter Aortic Valve Implantation, Surgical Aortic Valve Replacement
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Heart and Brain Research Group, Germany
Apical Periodontitis
Effect of Smear Layer on Endodontic Outcome
This study evaluated the effect of removal of smear layer on the success of primary root canal treatment.Patients requiring primary root canal treatment in mature mandibular first and second molars were allocated to either smear…
- Trial name
- NCT03277404
- Testing
- Root canal treatment with smear layer removal, Root canal treatment without smear layer removal
- Volunteers
- 86 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Cranial Waveform in Normal Patients as a Result of Cardiac Cycle, Healthy
500 "Normal" Adult Subjects Who Have Experienced no Known Brain Injury Will Participate in Collecting Data That Will Assist With the Optimization of the Diagnostic Capabilities of the Harmony in Detecting Neurologic Abnormalities.
The REFRESH study is designed to collect data related to a signal in the brain that MindRhythm has named the Headpulse. The Headpulse occurs as a natural movement of the brain in conjunction with the beating of the heart.
- Trial name
- REFRESH (NCT05203393)
- Testing
- Harmony Headset
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- MindRhythm, Inc.
Opioid Use, Pain, Postoperative
Outcome of Multimodal Anesthesia Bern
In the context of the ongoing opioid crisis in the USA and Europe, reducing perioperative opioid use is a growing priority. Multimodal anesthesia (MMA) offers a patient-centered alternative to opioid-free anesthesia, combining…
- Conditions
- Opioid Use, Pain, Postoperative, Postoperative Complications, Postoperative Nausea
- Trial name
- NCT06985069
- Testing
- General anesthesia applying multimodal anesthesia, General anesthesia using conventional opioid-based regimen
- Where
- Switzerland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Analgesia
Individualized Analgesia After Adenotonsillectomy
A high incidence of respiratory morbidity after adenotonsillectomy is reported in children with obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT02990910
- Testing
- Individualized opioid analgesia, conventional opioid analgesia
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Children's Hospital of Fudan University
Musculoskeletal Pain, Neurological Disorder
Reliability and Validity of HHIRS General Quality of Life Questionnaire
Quality of life is conceded by copious musculoskeletal and neurogenic conditions which are evaluated by manifold questionnaires.
- Trial name
- HHIRS-GQOL (NCT05350839)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Helping Hand Institute of Rehabilitation Sciences
Growth Failure, Atopy
The PREWEAN Study. Weaning of Preterm Infants During the First Year of Life.
In this Austrian observational study preterm infants born with a birth weight <1500 g and a gestational age <32 weeks will be investigated at the neonatal outpatient clinic.
- Conditions
- Growth Failure, Atopy, Adiposity, Cognitive Impairment
- Trial name
- PREWEAN (NCT02936219)
- Where
- Austria
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Bladder Cancer, Neurogenic Bladder Disorder
Use of Wearables Following Cystectomy- Part II
The goal of this observational study is to learn about the practical considerations for having health care providers respond in real-time to abnormalities detected remotely for patients recovering from cystectomy following…
- Conditions
- Bladder Cancer, Neurogenic Bladder Disorder, Cystectomy
- Trial name
- NCT07148765
- Testing
- Fitbit Sense 2, Smartphone application survey
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Acute Stroke
Body Composition and Acute Stroke
Body composition appears to be a prognostic factor for the severity and functional outcome of stroke patients. In this study the prognostic value of two bioimpedance parameters will be studied (skeletal mass index and phase…
- Trial name
- PREDISTROKE (NCT06589297)
- Testing
- Modified Rankin scale
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Knee Arthropathy
Effect of NLR and MPV on Early Postoperative Outcome in Lower Extremity Arthroplasty Operations
In the planned study the investigators want to evaluate the relation between postoperative complications and minor/ major morbidities, mortality and Mean Platelet Volume (MPV) and Neutrophil/ lymphocyte (N/L) ratio.
- Trial name
- NCT03148951
- Where
- Turkey (Türkiye)
- Volunteers
- 754 people
- Sponsor
- Akdeniz University
Shoulder Pain, Shoulder Mobility Impairment
Burden and Outcome of Shoulder Disorders in Primary Health Care
Consumption of medical care and outcome of shoulder pain and disability in primary care.
- Trial name
- NCT01300091
- Where
- Finland
- Sponsor
- Central Finland Hospital District
Traumatic Brain Injury
Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Primary aim: To determine the efficacy of two dosing regimens of TXA initiated in the prehospital setting in patients with moderate to severe TBI (GCS score ≤12).
- Trial name
- TXA (NCT01990768)
- Testing
- 1 gram Tranexamic Acid (TXA), 2 grams TXA, 0.9% Sodium Chloride injectable
- Where
- 12 sites in United States, Canada
- Volunteers
- 967 people
- Sponsor
- University of Washington
Osteoarthritis Knee
Effect of Mesenchymal Stem Cells in Primary Knee Osteoarthritis
Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. Incidence and prevalence of osteoarthritis rise with increasing age.
- Trial name
- NCT05783154
- Testing
- Autologous Adipose Tissue-Derived Mesenchymal Stem Cell
- Where
- Bangladesh
- Volunteers
- 84 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Oncology, Glioma
Monitoring of Neurological Symptoms, Treatment Tolerance, and Quality of Life Using the Resilience PRO Electronic Patient-reported Outcome Application in Patients With IDH-mutated Glioma
Patients with IDH-mutant glioma frequently experience symptoms such as fatigue, seizures, headaches, cognitive impairments (primarily attentional), and mood changes, which can significantly affect their health-related quality of…
- Trial name
- NEURO-PRO-GLIO (NCT07439302)
- Testing
- Neurocognitive assessment, Questionnaries QoL, Resilience Pro Application
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Sarcopenia
Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit
The primary aim of the study is to evaluate consequences of frailty in critically ill patients. We hypothesize that a higher frailty index (based on published questionnaires) predicts a longer surgical intensive care unit and…
- Conditions
- Critical Illness, Sarcopenia, Muscle Wasting
- Trial name
- NCT02270502
- Testing
- Ultrasound Philips CX50, Frailty Index Questionnaire, Muscle strength tests
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Massachusetts General Hospital
Cardiac Arrest, Hypothermia
Follow up After Survived Therapy With Mild Induced Hypothermia (MIH) After Restoration of Spontaneous Circulation (ROSC)
Sudden cardiac arrest (SCA) remains one of the major leading causes of death. Cognitive deficits are common in survivors of SCA.
- Trial name
- NCT01083069
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Pain, Labor Complications
Dilute Versus Concentrated Epidural Bupivacaine in Labor
This study studies labor epidural analgesia and compares dilute (0.0625%) with concentrated (0.25%) bupivacaine. We hypothesize that patients randomize to receive the concentrated drug will require more drug, will have a more…
- Trial name
- NCT00197327
- Testing
- Epidural bupivacaine (0.25% versus 0.0625%)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Informal Caregivers, Low Back Pain
Biomechanical Validation of the Caregiver Assisted Transfer Technique Instrument
As of 2020, 53 million Americans provide unpaid care to an individual with a disability. One commonly performed activity of daily living (ADL) provided by informal caregivers is assisted transfers, which requires moving an…
- Conditions
- Informal Caregivers, Low Back Pain, Biomechanics
- Trial name
- NCT06013878
- Testing
- Transfer Training with clinician
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
TBI Traumatic Brain Injury
Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients.
The purpose of this study is to demonstrate the efficacy of early continuous intravenous infusion of hypertonic saline solution (HSS) to improve survival and independence in daily life activities (at 6 months) of patients with…
- Trial name
- COSMOS-TBI (NCT07319208)
- Testing
- Hypertonic saline solution
- Where
- 23 sites in France
- Volunteers
- 760 people
- Sponsor
- Nantes University Hospital