Clinical trials: Neurological Outcome
Cardiac Arrest, Hypothermia
COOL-Trial: Outcome With Invasive and Non-invasive Cooling After Cardiac Arrest
Sudden cardiac arrest (SCA) remains one of the major leading causes of death. Cognitive deficits are common in survivors of SCA.
- Trial name
- COOL (NCT00843297)
- Testing
- Coolgard, ArcticSun, Conventional treatment
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Leipzig
Cancer Pain
Individualized Pharmaceutical-care for Inpatients With Cancer Pain
The purpose of the study is to investigate the impact of pharmaceutical care on cancer pain treatment for opioid-tolerant inpatients
- Trial name
- NCT03455023
- Testing
- pharmaceutical care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhejiang Cancer Hospital
Treatment Outcome, Muscle Dystonia
Quantifying Muscle Tone in Patients With Brain Injury - a Feasibility Study
This project will determine the feasibility and validity of measuring elbow muscle flexor stiffness in a population of patients with sub-acute severe acquired brain injury using two measurement methods, the portable spasticity…
- Conditions
- Treatment Outcome, Muscle Dystonia, Spasticity, Muscle, Muscle Tightness
- Trial name
- NCT04207632
- Testing
- Botulinum toxin type A injection
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hemianopsia, Homonymous
Testing of a Functional Outcome Measure for Those With Visual Field Defects
This study is designed in two Phases. In phase 1, the Functional Outcome Measure will be tested to determine its validity and reliability in three populations, subjects that have not had a stroke and have no visual field defect…
- Trial name
- FOM (NCT00731796)
- Testing
- Functional Outcome Measure
- Where
- 3 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- NovaVision, Inc.
Asphyxia Neonatorum
Biomarkers And Neurological Outcome in Neonates (BANON)
Validation of biomarkers in a human population for their ability to diagnose the severity of neonatal asphyxia. These biomarkers linked to asphyxia have been identified in animal studies and a preliminary human study.
- Trial name
- NCT03357250
- Where
- 11 sites in Germany
- Volunteers
- 553 people, healthy volunteers welcome
- Sponsor
- Life Science Inkubator
Pain, Disability
Do Benzodiazepines Improve the Outcome of Mechanical Physiotherapy for Lumbar Disk Prolapse
Sixty patients were randomized to receive either placebo or diazepam in addition to mechanical physiotherapy and analgesics for the first 7 days of conservative treatment of clinically and radiologically confirmed lumbar disk…
- Conditions
- Pain, Disability, Paresis
- Trial name
- NCT00533286
- Testing
- benzodiacepine
- Sponsor
- University Hospital Tuebingen
Chronic Pain, Analgesia
QSPainRelief-STRAT
Investigating the clinical outcomes of drug combinations (opioid + medication acting on the central nervous system) in patients suffering from persistent pain (pain lasting for at least three months) through patient-reported…
- Conditions
- Chronic Pain, Analgesia, Adverse Drug Event, Drug Interaction
- Trial name
- QSPR-STRAT (NCT06244706)
- Testing
- Opioid drug + CNS-acting add-on drug
- Volunteers
- 150 people
- Sponsor
- Université Catholique de Louvain
Chronic Pain
Lifestyle Modification Program for Patients With Chronic Pain Conditions
In this observational study the effects of a Lifestyle Modification Program - offered as a semi-residential day care clinic - on pain, disability, quality of life and satisfaction with life will be investigated.
- Trial name
- POSITAG (NCT01805947)
- Testing
- Lifestyle Modification
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Universität Duisburg-Essen
Knee Osteoarthritis, Anxiety
Comparison of Music and Ambient Noise Cancellation in Patients Undergoing Total Knee Arthroplasty (TKA)
The aim of this clinical trial is to compare the effects of music and ambient noise cancellation during total knee arthroplasty and to analyse the effects on patients.
- Conditions
- Knee Osteoarthritis, Anxiety, Post Operative Pain, Noise Exposure
- Trial name
- TKA (NCT06401018)
- Testing
- No noise cancellation and no music playing, Noise cancelled but not allowed to listen to music, Music is played but noise is not cancelled
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Single-visit, Periapical Periodontitis
Postoperative Pain and Success of Single-Visit Root Canal Treatment Using Different Root Canal Sealers in Asymptomatic Teeth
This study evaluates the postoperative pain and long-term clinical and radiographic success of single-visit primary root canal treatment in asymptomatic teeth with periapical lesions.
- Trial name
- NCT07868315
- Testing
- One-Fill, TotalFill, AH Plus + Single Cone
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul Medipol University Hospital
Ischemic Stroke
Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study
The primary study objective is to assess the feasibility of using the MindFrame System to safely and effectively restore blood flow in a thrombotic neurovascular occlusion in patients experiencing an ischemic stroke.
- Trial name
- PRIISM (NCT00810095)
- Testing
- MindFrame System
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MindFrame, Inc.
Musculoskeletal Pain
Transcultural Adaptation and Validation to Spanish of the OSPRO Questionnaires
Clinical guidelines for managing musculoskeletal pain recommend first, assessing and identifying any signs of severe physical conditions (i.e."red flags") and then, asessing the psychosocial prognostic factors of poor outcomes…
- Trial name
- SpanishOSPRO (NCT05869695)
- Testing
- OSPRO-ROS Questionnaire, OSPRO-YF Questionnaire
- Where
- 2 sites in Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Brain Neoplasms, Carcinoma, Non-Small-Cell Lung
Study of Neurologic Progression With Motexafin Gadolinium and Radiation Therapy (SMART)
The primary purpose of the study is to determine if patients with brain metastases from non-small cell lung cancer treated with Motexafin Gadolinium and whole brain radiation therapy retain their neurologic function and ability…
- Conditions
- Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Metastases, Neoplasm
- Trial name
- NCT00054795
- Testing
- Motexafin Gadolinium
- Where
- 92 sites in United States, Australia and 6 more
- Volunteers
- 550 people
- Sponsor
- Pharmacyclics LLC.
Pain
Does Preventive Analgesia Improve the Outcome of Demerol-Vistaril Procedural Sedations in Pediatric Dentistry
All healthcare providers strive continually to improve the outcome of their treatment approaches. The investigators hypothesize that preventive analgesics administered before a child is sedated with a Demerol-Vistaril regimen…
- Trial name
- Analgesia (NCT01971853)
- Testing
- Oral Analgesics
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiorespiratory Arrest
Predictive Electrophysiological Score of the Neurological Prognosis Post Cardiac Arrest
Cardiac arrest (CA) is a major public health problem (1) because of its frequency (30000 to 50000 new cases of CA per year in France), a high mortality 80-90% and a relevant morbidity : 50% of survivors have cerebral sequela.
- Trial name
- CA-EEG (NCT02886039)
- Testing
- Electroencephalogram
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Montpellier
Stroke, Sleep Wake Disorders
The SLEEPR Study: SLEep Effects on Post-stroke Rehabilitation
Sleep is critical for health and quality of life; however, little is known about the prevalence or impact of non obstructive sleep apnea (non-OSA) sleep disorders in people with stroke.
- Conditions
- Stroke, Sleep Wake Disorders, Rehabilitation, Recovery of Function
- Trial name
- SLEEPR (NCT05012605)
- Testing
- Observation
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- State University of New York - Upstate Medical University
Back Pain, Radiculopathy Lumbar
Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy
SNRB, as measured by the change in pain and objective functional ability, can solicit crucial information regarding a patient's clinical picture and can predict a patient's outcome post-surgery.
- Conditions
- Back Pain, Radiculopathy Lumbar, Degenerative Lumbar Spinal Stenosis
- Trial name
- NCT03801356
- Testing
- Selective Nerve Root Block
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The Cleveland Clinic
Cardiac Arrest, Out-Of-Hospital, Cognitive Impairment
Prediction of Delayed Cognitive Impairment in Cardiac Arrest Survivors With Good Neurological Outcomes
The objective of this observational study is to provide basic data for predicting and analyzing the occurrence and causes of delayed cognitive impairment, an important factor in the quality of life, among discharged patients who…
- Trial name
- NCT05830422
- Testing
- nothing
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Chungnam National University Hospital
Stroke, CVA (Cerebrovascular Accident)
Translation And Psychometric Testing Of The Turkish Version Of Fugl-Meyer Assessment
The aim of this methodological study is to adapt the Fugl-Meyer assessment to Turkish culture and to test its validity and reliability in acute phase stroke patients.
- Conditions
- Stroke, CVA (Cerebrovascular Accident), Hemiplegia and/or Hemiparesis Following Stroke
- Trial name
- FMA-TR (NCT05823298)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Intellectual Disability
Motor and Cognitive Dual-task Gait Training Effect Functional Outcome in Intellectual Disability
To find out the comparative effects of motor and cognitive dual gait training on improving the balance control and mobility skills among intellectual disable patients.
- Trial name
- NCT05334498
- Testing
- Motor dual-task gait training, Cognitive dual-task gait training
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University