Clinical trials: Neurological Outcome
Schizophenia Disorder
CRacking the HEterogeneity of Social Outcome Through Neuropsychophysiological Profiles
CRHESO aims at overcoming the considerable burden of mental disorders, which affects both psychosocial well-being and societal welfare, through a multidisciplinary and integrated approach to explore and remediate dimensions…
- Trial name
- CRHESO (NCT06869616)
- Testing
- Cognitive Remediation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Preterm, General Movements
Fidgety Movements of Preterm Neonates Included in COSGOD III
The evidence on the effects of clinical care with cerebral NIRS (Near-infrared spectroscopy) monitoring on short term neurological outcome, displayed by fidgety movements between six to 20 weeks post term, are still uncertain.
- Conditions
- Preterm, General Movements, Fidgety Movements, Near Infrared Spectroscopy
- Trial name
- Figdety_Ms (NCT06105333)
- Testing
- standard care plus cerebral oxygen saturation monitoring with a dedicated treatment guideline
- Where
- 2 sites in Austria
- Volunteers
- 183 people
- Sponsor
- Medical University of Graz
Delirium, Anxiety
Intraoperative Midazolam on Delirium Outcome of Elderly Patients
This study was a multicenter, randomized, double-blind, placebo-controlled trial to treat elderly surgical patients with low-dose midazolam or placebo for anesthesia induction.
- Trial name
- IMODE (NCT06963112)
- Testing
- Midazolam, Saline
- Where
- 5 sites in China
- Volunteers
- 612 people
- Sponsor
- Chinese PLA General Hospital
FBSS, Pain, Intractable
PET Patterns, Biomarkers and Outcome in Burst SCS Treated FBSS Patients
The primary aim of this study is to investigate cerebral mechanisms of burst stimulation in Failed Back Surgery Syndrome (FBSS) patients treated with Burst Spinal Cord Stimulation (SCS) for chronic back and leg pain.
- Conditions
- FBSS, Pain, Intractable, Low Back Pain, Radicular; Neuropathic, Lumbar, Lumbosacral
- Trial name
- PET-SCS (NCT03419312)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Uppsala University
Unstable Angina, Non-ST-Elevation Myocardial Infarction
Diagnosis and Treatment of Acute Coronary Syndrome in the ED & the Impact of Rapid Bedside cTnl on Outcome.
The primary outcome in this study will be time to discharge for low-risk patients and therapeutic turnaround time for patients with NSTEMI or unstable angina.
- Trial name
- NCT00276432
- Testing
- iSTAT point of care analyzer
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Mayo Clinic
Psychomotor Impairment
Correlation Between Cerebral Oxygenation and Neurodevelopment in VLBW Preterm Infants.
The recent improvements in neonatal intensive care have led to a substantial increase in the survival rate of preterm infants; nevertheless, this population is still at high risk for long-term neurodevelopmental disabilities.
- Trial name
- NCT03104296
- Testing
- Griffiths Mental Development Scales
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Lumbar Radiculopathy
The Effectiveness of Pain Neuroscience Education in At-risk Patients Following Surgery for Lumbar Radiculopathy
This study aims to assess the effectiveness of perioperative pain neuroscience education (PPNE) in patients who are at risk for unfavorable outcome following surgery for lumbar radiculopathy.
- Trial name
- B²EARS (NCT05047679)
- Testing
- Perioperative Pain Neuroscience Education, Perioperative Biomedical Education
- Where
- 4 sites in Belgium
- Volunteers
- 6 people
- Sponsor
- Vrije Universiteit Brussel
Fibromyalgia
Fibromyalgia Outcome Research Trial Evaluating Synergistic Suppression of HSV-1
Randomized, double-blind, placebo-controlled, 16-week study designed to explore the safety and efficacy of IMC-1 for the treatment of patients with fibromyalgia.
- Trial name
- FORTRESS (NCT04748705)
- Testing
- IMC-1
- Where
- 42 sites in United States
- Volunteers
- 422 people
- Sponsor
- Virios Therapeutics, Inc.
Heart Arrest, Anesthesia
Perioperative Cardiac Arrest and Outcome
With ethical approvement, the investigators want to assess the incidence, circumstances and outcomes of patients with perioperative cardiac arrests over a period of 8 years.
- Trial name
- POCA (NCT05316779)
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pain
What is the Effect of a Course for Treatment Providers on Their Patient Outcome
The goal is to acquire more in-depth knowledge on physical therapists' attitudes towards and beliefs about psychosocial factors in back pain, how physical therapists integrate psychosocial factors into their clinical practice and…
- Trial name
- NCT00902642
- Testing
- an eight day university training course designed to integrating psychosocial factors in clinical practice on a patient level
- Where
- Sweden
- Volunteers
- 364 people
- Sponsor
- Örebro County Council
Analgesia, Epidural, Instrumental Delivery
The Randomised Epidural Analgesia in Term Delivering Women Trial (TREAT)
The objective of the study: to assess the impact of a proactive policy of offering EA at the start of labour as compared to a restrictive policy or care as usual.
- Conditions
- Analgesia, Epidural, Instrumental Delivery, Maternal Outcome, Neonatal Outcome
- Trial name
- TREAT (NCT01261689)
- Testing
- Ropivacaine/ Sufentanil according to local hospital protocol, Care-as usual pain treatment
- Where
- 2 sites in Netherlands
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Neurological Outcome, Survival From First Diagnosis Metastatic Spinal Cord Compression to Death
Emergency Radiotherapy in Metastatic Spinal Cord Compression of Patients With Non-small Cell Lung Cancer
Acute neurological deficit in metastatic spinal cord compression is an emergency condition in radiation oncology. Despite some reports about the high efficacy of radiation treatment for oncological emergencies, a standard of care…
- Trial name
- CK-INF (NCT02000518)
- Testing
- external beam radiotherapy
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Heidelberg University
Gastroparesis
Gastroparesis Outcome Longitudinal Database Enrolled Numerically
GOLDEN is a longitudinal database of patients with the symptoms (Sx) of gastroparesis (Gp) who were seen and recorded at the University of Louisville from 2012 and is ongoing.
- Trial name
- GOLDEN (NCT03876288)
- Testing
- GI Neuromodulation, Immunotherapy, Pyloric Therapies
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Louisville
Delirium, Fatigue
The Impact of Non-motor Symptom on the Outcome of Stroke Subjects
The most common symptoms of stroke were focal weakness, hemiparesis, speech disturbance, diplopia and ataxia. Beside those symptoms, there are still many symptoms occurring after stroke, which may affect the life quality of…
- Conditions
- Delirium, Fatigue, Depression, Insomnia
- Trial name
- NMCHYIS (NCT06854497)
- Testing
- MMSE (Mini-Mental State Examination),NIHSS (NIH Stroke Scale) and mRS (Mordified Rankin Score), Confusion Assessment Methods (CAM), PSQI Pittsburgh Sleep Quality Index, Respiratory polygraphy
- Where
- Taiwan
- Volunteers
- 1,500 people
- Sponsor
- Chiayi Christian Hospital
Pain, Postoperative
Postoperative Pain Treatment in Total Hip Arthroplasty: A Study to Assess the Effect of Local Analgesia
The purpose of this study is to determine whether the investigator standardized pain treatment plus local pain treatment is more effective than the investigator standardized pain treatment plus placebo in total hip arthroplasty.
- Trial name
- NCT00603083
- Testing
- Ropivacaine, Ketorolac and Adrenalin
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Vejle Hospital
Muscular Atrophy
Study in ICU Patients Regarding Protein Intake and CT-derived Body Composition
The purpose of this study is to determine whether protein intake during the first days of intensive care admission, in relation to body composition at intensive care admission as assessed on computed tomography scans made during…
- Trial name
- NCT02817646
- Testing
- Computed tomography scan made for clinical reasons, Nutrition as per hospital protocol
- Volunteers
- 800 people
- Sponsor
- Amsterdam UMC, location VUmc
Cardiac Death, Congestive Heart Failure
Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery
This is an observational study designed to monitor the course of the fraction of reticulated platelets and the correlation thereof to major adverse cardiac and cerebrovascular events after noncardiac surgery.
- Conditions
- Cardiac Death, Congestive Heart Failure, Angina Pectoris, Stroke
- Trial name
- NCT02097602
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Dehydrogenase E1 Alpha Deficiency
Natural History Study of Pyruvate Dehydrogenase Deficiency
Pyruvate dehydrogenase (PDH) deficiency is one of the most common mitochondrial disorders. Patients with this genetic condition have difficulty utilising carbohydrates to produce energy and develop a combination of problems…
- Conditions
- Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Dehydrogenase E1 Alpha Deficiency, Pyruvate Dehydrogenase E1-Beta Deficiency, Pyruvate Dehydrogenase E2 Deficiency
- Trial name
- NCT05257005
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Cardiac Arrest
Fluid Shifts in Patients Treated With Therapeutic Hypothermia After Cardiac Arrest
Therapeutic hypothermia after cardiac arrest har shown to improve the rate of survival in a significant way. However hypothermia also causes leak of fluid into the surrounding tissue.
- Trial name
- NCT00347477
- Testing
- HyperHAES vs. RA-solution/NaCl
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- Haukeland University Hospital
Postoperative Pain, Postoperative Complications
A Comparison of Silicone Versus Polyvinylchloride (PVC) Drains Following VATS Lobectomy
The goal of this prospective randomized clinical trial is to compare the impact of the chest tube type on pain, chest drainage efficacy and early postoperative outcome following VATS lobectomy for lung cancer.
- Trial name
- NCT06425601
- Testing
- SIL drain, PVC drain
- Where
- Slovenia
- Volunteers
- 80 people
- Sponsor
- University Medical Centre Ljubljana