Clinical trials: Neurological Outcome
Nutrition, Muscle Loss
KetoNiFast: Cyclic Enteral Daytime Feeding With Ketogenic Nighttime Fasting
A physiological human nutrition includes circadian feeding and nighttime fasting during sleep. There is increasing evidence, that this natural fasting episode over nighttime majorly contributes to repair processes of the human…
- Conditions
- Nutrition, Muscle Loss, Inflammatory Response
- Trial name
- KetoNiFast (NCT06535815)
- Testing
- Cyclic enteral feeding with nighttime fasting and exogenous ketone salt supplementation (ß-hydroxybutyrate)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- University Hospital of Cologne
Neovascular Age-related Macular Degeneration
Study of Innovative Multimodal Imaging Biomarkers to Predict Anatomical Outcome in Naive Patients With wAMD Treated With Brolucizumab.
The purpose of this study was to identify innovative early imaging parameters as predictors of the long-term clinical response to brolucizumab in terms of fluid resolution in patients with wet Age-related Macular Degeneration…
- Trial name
- IMAGINE (NCT04774926)
- Testing
- Brolucizumab
- Where
- 20 sites in Italy
- Volunteers
- 122 people
- Sponsor
- Novartis Pharmaceuticals
Syncope, Arrhythmia
Mobile Cardiac Outpatient Telemetry for Unexplained Syncope
This study seeks to provide evidence that use of Philips mobile cardiac outpatient telemetry (MCOT) devices may improve patient care for patients who present to emergency departments (EDs) with syncope, which is a temporary loss…
- Conditions
- Syncope, Arrhythmia, Near Syncope, Arrhythmias, Cardiac
- Trial name
- NCT05957315
- Testing
- Mobile Cardiac Outpatient Telemetry Device (MCOT)
- Volunteers
- 160 people
- Sponsor
- Carilion Clinic
Migraine, Headache
Long-term Atogepant in Real-world Practice
This prospective multicentre observational study aims to evaluate the long-term effectiveness, safety, tolerability, and treatment persistence of atogepant for migraine prevention in routine clinical practice.
- Conditions
- Migraine, Headache, Headache (Migraine), Migraine Disease
- Trial name
- GEMA PROJECT (NCT07699549)
- Testing
- Atogepant 60 mg, Headache diary, Patient-reported outcome measures
- Where
- Spain
- Volunteers
- 513 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Anesthesia, Analgesia
Patient Reported Outcome After Bariatric Surgery
Prospective association study to analyse patients' outcome after bariatric surgery. Outcome comprises postoperative pain, analgesia, postoperative side-effects, long-lasting pain, patients' impairment in daily living.
- Conditions
- Anesthesia, Analgesia, Bariatric Surgery
- Trial name
- NCT03490630
- Where
- Switzerland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson Disease, Multiple System Atrophy
Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms
The goal of this observational study is to learn about the impact of the different types of pain and of the domains involved in the autonomic disorders of inpatients and outpatients diagnosed with Parkinson disease (PD) and…
- Trial name
- NCT05748028
- Testing
- Rehabilitation, Administration of Clinical scales
- Where
- 9 sites in Italy
- Volunteers
- 280 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Chronic Pain, Neck Pain
Comparison Between Soft Tissue Mobilization and Strengthening Exercises in Management of Local Neck Syndrome
A single-blinded, parallel-group randomized controlled trial was conducted at the national institute of rehabilitation medicine, Pakistan, from April to July 2016, on 30 females who were recruited through non-probability…
- Trial name
- NCT05227963
- Testing
- soft tissue mobilization, neck isometric strengthening exercises
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Health Education Research Foundation (HERF)
Stroke
Nutritional Status in Subacute Stroke Patients Under Rehabilitation
Recently, is becoming more evident a relationship between malnutrition, stroke-related sarcopenia and/or altered systemic oxidative status in patients with subacute stroke .
- Trial name
- Nutristroke (NCT04923165)
- Testing
- robotic assisted intervention, biochemical analyses, BIA, hand grip
- Where
- Italy
- Volunteers
- 119 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012971
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Stable Angina, Unstable Angina
COMBO-Stent in Patients on Chronic Anticoagulant Therapy (COSTA) COSTA-Bleed and COSTA-Outcome Trials
Prospective, multi-centre, randomized, open-label, parallel comparisons to evaluate the incidence of bleedings (COSTA-Bleed) and the incidence of ischemic and bleeding events (COSTA-Outcome) following a therapy with the abluminal…
- Conditions
- Stable Angina, Unstable Angina, STEMI, NSTEMI
- Trial name
- COSTA (NCT02723981)
- Testing
- COMBO-Stent, Clopidogrel, Vitamin K Antagonist, Rivaroxaban, Dabigatran, Any drug eluting stent oder bare metal sent
- Where
- 10 sites in Germany
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Head Injuries, Subarachnoid Haemorrhage
Impact of Cranioplasty On Cerebral Perfusion
The purpose of this study is to examine the impact of cranioplasty on cerebral hemodynamic and blood flow as prognostic factor in patients receiving decompressive craniectomy for Head injuries, Subarachnoid haemorrhage…
- Conditions
- Head Injuries, Subarachnoid Haemorrhage, Intra-cerebral Haemorrhage, Cerebral Thrombosis
- Trial name
- CCP (NCT01113645)
- Testing
- Cerebral perfusion evaluation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Irritable Bowel Syndrome
Experience Sampling Method for Symptom Assessment in Irritable Bowel Syndrome
Reliable patient reported outcome measures (PROM's) for symptom assessment in irritable bowel syndrome are essential in order to investigate natural disease course and potential treatment options aimed at symptom improvement…
- Trial name
- NCT02880722
- Where
- Netherlands
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pupillometry Index in Brain Lesion
Comparison of 2 Pupillometric Indices in Cerebral Brain Patients
Pupillary examination, and in particular pupillary reactivity to light, is fundamental to the monitoring and follow-up in intensive care units of patients with acute brain injury.
- Trial name
- LYNX (NCT05567978)
- Testing
- pupillometry index
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Ischemic Brain Injury
Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients
The main purpose of this study is to explore whether xenon is neuroprotective in humans. In addition, the purpose is to explore the underlying mechanisms for the possible synergistic neuroprotective interaction of xenon and…
- Trial name
- Xe-hypotheca (NCT00879892)
- Testing
- xenon, Hypothermia
- Where
- 10 sites in United States, Finland
- Volunteers
- 110 people
- Sponsor
- Turku University Hospital
Dystonia
Chronic Outcome Monitoring for DBS in Dystonia
Dystonia is a severe movement disorder involving increased muscular activity and can be very variable. To date, the treatment of dystonia is challenging.
- Trial name
- COMMED (NCT07244549)
- Where
- 3 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Charite University, Berlin, Germany
Neurodevelopmental Abnormality, Congenital Heart Disease
The Swiss Neurodevelopmental Outcome Registry for Children With CHD
Introduction: Congenital heart disease (CHD) is the most frequent birth defect. As survival has significantly improved, attention has turned to neurodevelopmental outcomes of children undergoing heart surgery in early infancy.
- Conditions
- Neurodevelopmental Abnormality, Congenital Heart Disease, Cardiac Disease, Intensive Care Neurological Disorder
- Trial name
- SwissORCHID (NCT05996211)
- Where
- 3 sites in Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University Children's Hospital, Zurich
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Rehabilitation, Treatment Outcome
Effects of Exercise Therapy and Soft Brace on Knee Osteoarthritis
The primary aim of the study is to investigate the effects of supervised exercise therapy and education on the immediate response to using a soft knee brace in patients with knee osteoarthritis (OA).
- Conditions
- Rehabilitation, Treatment Outcome, Pain, Knee Brace
- Trial name
- NCT03949400
- Testing
- Exercise therapy and education.
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University College of Northern Denmark
Stroke, Ischemic
Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT)
The potential benefit of intraarterial tenecteplase in acute basilar artery occlusion (BAO) patients with successful reperfusion following endovascular treatment (EVT) has not been studied.
- Trial name
- NCT05657457
- Testing
- Tenecteplase
- Where
- China
- Volunteers
- 145 people
- Sponsor
- General Hospital of Shenyang Military Region