Clinical trials: Neurological Outcome
Motor Deficits, Lumbar Discectomy
Investigation of Preoperative Factors Influencing the Outcome of Motor Deficits in Patients Undergoing Lumbar Microdiskectomy
Lumbar disc herniations may result in lower limb weakness. In such cases, there is a strong indication for surgical intervention through microdiscectomy.
- Conditions
- Motor Deficits, Lumbar Discectomy, Muscle Weakness, Paresis
- Trial name
- NCT07413302
- Where
- 3 sites in Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Pain, Chronic, Pain, Neuropathic
Caregiver Burden and Correlation With Clinical Outcome in Spinal Cord Stimulation for Chronic Neuropathic Pain
Prospective multicentric observational trial on caregiver burden, caregiver satisfaction and clinical outcome in spinal cord stimulation for chronic neuropathic pain.
- Conditions
- Pain, Chronic, Pain, Neuropathic, Failed Back Surgery Syndrome
- Trial name
- CAREstim (NCT04737746)
- Where
- 2 sites in Belgium
- Volunteers
- 42 people
- Sponsor
- AZ Delta
SARS-CoV-2, Post-acute COVID-19 Syndrome
Neurological Outcome After SARS-CoV-2 Infection
Wider research context: Since the recognition of SARS-CoV-2 outbreak in 2019, there are now over 126 million COVID-19 cases worldwide with more than 2.7 million deaths.
- Trial name
- ATTRACT (NCT05025839)
- Testing
- No Intervention
- Where
- Austria
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Pain, Stenosis
Clinical Outcome Study of the Triad Allograft for Posterior Lumbar Fusion
The purpose of the study is to prospectively measure pain, function, and patient satisfaction in 70 consecutive patients treated by lumbar fusion using the Triad allograft.
- Conditions
- Pain, Stenosis, Spondylolisthesis
- Trial name
- NCT00205101
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Ischemic Stroke
Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study
The primary study objective is to assess the feasibility of using the MindFrame System to safely and effectively restore blood flow in a thrombotic neurovascular occlusion in patients experiencing an ischemic stroke.
- Trial name
- PRIISM (NCT00810095)
- Testing
- MindFrame System
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MindFrame, Inc.
Brain Injuries, Traumatic
Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury
Post-traumatic brain hypoxia/ischemia develops hours after traumatic brain injury (TBI), and its intensity is directly related to the neurological outcome.
- Trial name
- OXY-TC (NCT02754063)
- Testing
- PbtO2 probes, No PbtO2 probes
- Where
- 26 sites in France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Grenoble
Developmental Dysgraphia
Sensory Motor Lateralization as Handwriting Intervention in School-Based OT
Children who attend School-Based Occupational Therapy (SBOT) show mixed dominance and a liable decreased in the structural and functional differentiation between the two hemispheres.
- Trial name
- SML (NCT03903614)
- Testing
- SML, CON
- Volunteers
- 16 people
- Sponsor
- Mary H. Teng
Stroke, Acute, Cerebrovascular Disorders
Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion
This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy…
- Conditions
- Stroke, Acute, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- TEMPOS (NCT06633809)
- Testing
- Immediate endovascular therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sir Run Run Shaw Hospital
Low Back Pain, Pain, Chronic
What Determines a Positive Outcome of Spinal Manipulation for Persistent Low Back Pain: Stiffness or Pain Sensitivity? A Randomized Trial
Introduction Several treatment methods have been proposed to ease the burden of low back pain (LBP) but none are clearly superior.
- Trial name
- POPS (NCT04086667)
- Testing
- Spinal manipulation
- Where
- Denmark
- Volunteers
- 132 people
- Sponsor
- Spine Centre of Southern Denmark
Pain, Chronic
Prediction of Clinical Outcome in Lumbar ESPB
The primary endpoint of this study was to identify that Perfusion index (PI) has any predictive value for the treatment outcome of cervical radiculopathy
- Trial name
- NCT05723367
- Testing
- lumbar ESPB group where ESPB is performed at L4 with local anesthetics 20ml
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Keimyung University Dongsan Medical Center
Cardiac Arrest (CA), Anoxic Brain Injury
Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest
WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838.
- Conditions
- Cardiac Arrest (CA), Anoxic Brain Injury, Comatose Survivors of Cardiac Arrest, EEG
- Trial name
- WAKE-OHCA (NCT06979700)
- Testing
- Automated Pupillometry, Transcranial Doppler Ultrasound, Optic Nerve Sheath Diameter
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
Pain
Using Diffuse Noxious Inhibitory Control (DNIC) to Predict Acupuncture Therapy Outcome: A Pilot Study
The investigators hypothesize that acupuncture modifies the DNIC efficiency and that DNIC can serve as a predictor to identify 'good responders' to acupuncture early in therapy.
- Trial name
- NCT01088867
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Washington
Low Back Pain
Influence of Kinesiophobia on the Outcome of Chronic Low Back Pain Condition
Though large body of evidence reported association between pain and kinesiophobia, there are paucity of studies in associating kinesiophobia to muscle endurance and position sense in patients with Chronic lower back pain [CLBP].
- Trial name
- NCT05079893
- Testing
- Case control study
- Volunteers
- 600 people
- Sponsor
- Gulf Medical University
SPINAL Fracture, Burst Fracture
Surgical Versus Non-Surgical Treatment of Thoracolumbar Burst Fracture
Treatment for acute traumatic thoracolumbar burst fractures differs significantly across the world in patients without neurological impairments and without damage to the posterior column of the spine.
- Conditions
- SPINAL Fracture, Burst Fracture, Spinal Instability of Thoracolumbar Region
- Trial name
- A34RCT (NCT05769114)
- Testing
- Surgical stabilization
- Where
- 2 sites in Switzerland
- Volunteers
- 52 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Motor Activity, Muscle Strength
Critical Care Observation of Motor Activity (COMA) and SICU Outcomes
In the surgical intensive care unit (SICU), goals of critical care are often discussed in long-term ventilated patients around the time of extubation.
- Conditions
- Motor Activity, Muscle Strength, Muscle Weakness
- Trial name
- COMA (NCT02994641)
- Testing
- COMA Score Assessment
- Where
- United States
- Volunteers
- 761 people
- Sponsor
- Massachusetts General Hospital
Low Back Pain
Development of the Work In Progress Questionnaire
The aim of this study is to describe the development of the Work In Progress questionnaire, a tool designed to evaluate commitment in persons, and its psychometric validation process in the context of low back pain.
- Trial name
- WIP (NCT05932043)
- Testing
- This is a non-interventional study
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- International Institute of Behavioral Medicines
Heart Arrest, Out-Of-Hospital, Brain Swelling
The Effect of Lumbar CSF Drainage on the Neurologic Outcome Improvement in OHCA Underwent TTM
Aim: The investigators aim to evaluate the effect of lumbar cerebrospinal fluid (CSF) drainage on neurologic outcome in post-cardiac arrest (CA) patients treated with target temperature management (TTM).
- Trial name
- NCT04328974
- Testing
- lumbar CSF drainage
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Chungnam National University Hospital
Delirium, Stress Disorders, Post-Traumatic
Sedation Influence on Delirium and Post-traumatic Stress-disorder as a Result of Hospitalization in Intensive Care
The aim of this study is to investigate if sedation of Intensive Care Unit (ICU) patients influences the development of delirium during their ICU stay and if incidences of delirium have an impact on the development of…
- Trial name
- NCT01291368
- Where
- 2 sites in Denmark
- Volunteers
- 248 people
- Sponsor
- University of Aarhus
Lumbar Radiculopathy
Effect of Transfer of Energy Capacitive and Resistive on Chronic Discogenic Sciatica
The goal of this clinical trial is to evaluate the effect of Transfer of Energy Capacitive and Resistive (TECAR) on pain, functional disability and electrophysiological parameters in adults with chronic discogenic sciatica .
- Trial name
- NCT07841405
- Testing
- Transfer of Energy Capacitive and Resistive (TECAR) therapy, conventional physical therapy program
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Primary Mitochondrial Disease
Natural History Study of Mitochondrial Myopathy
The goal of this observational study is to develop and validate tools to measure disease course in patients with primary mitochondrial myopathy (PMM).
- Trial name
- NCT05250375
- Where
- United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia