Clinical trials: Neurology
Neurologic Deficits, Neurologic Disorder
NeuroSeq: A Prospective Trial to Evaluate the Diagnostic Yield of Whole Genome Sequencing (WGS) in Adult Neurology
Prospective, multi-site, single-arm study to evaluate the diagnostic yield of cWGS in adults with neurological disorders. A single cohort naive of genetic testing will receive standard of care testing for 180 days followed by…
- Conditions
- Neurologic Deficits, Neurologic Disorder, Neurologic Abnormalities
- Trial name
- NeuroSEQ (NCT04170985)
- Testing
- clinical Whole Genome Sequencing
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Illumina, Inc.
COPD , Neurology , ICU, Alzheimer
Assessment of Malnutrition in Hospitalized Patients: a Quasi Study
Malnutrition among hospitalized patients is a critical, yet often overlooked, public health issue associated with increased complications, longer hospital stays, higher mortality, and greater healthcare costs.
- Conditions
- COPD , Neurology , ICU, Alzheimer, Alzheimer s Disease
- Trial name
- AMMRP (NCT07473492)
- Testing
- Nutritional Assessment and Medication Review
- Volunteers
- 300 people
- Sponsor
- AlFayhaa General Hospital
Parkinson Disease
Simvastatin as a Neuroprotective Treatment for Moderate Parkinson's Disease
Participants are randomly allocated to one of two treatment groups. In one group, participants are given capsules of simvastatin to take orally (by mouth) for 24 months.
- Trial name
- PD STAT (NCT02787590)
- Testing
- Simvastatin
- Where
- 24 sites in United Kingdom
- Volunteers
- 235 people
- Sponsor
- University Hospital Plymouth NHS Trust
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Efficacy and Safety Study of I10E in Treatment of Patients With CIDP
Primary objective: To assess the efficacy of I10E in improving the disability of patients with CIDP. Secondary objective: To assess the safety of I10E in patients with CIDP.
- Trial name
- PRISM (NCT02293460)
- Testing
- I10E
- Where
- 33 sites in France, Italy and 4 more
- Volunteers
- 44 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Epilepsy Syndrome
Cognitive Impairments in Children With Epilepsy
Since the proportion of language and attentional difficulties in patients with epilepsy is recognized, both in the literature and in the clinical experience of practitioners, it is appropriate to propose a complete…
- Trial name
- NCT05097742
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
HIV Infections
Effects of Anti-HIV Therapy on Nervous System Function
The purpose of this study is to observe the way two different anti-HIV treatment strategies affect nerve and brain function in adults with HIV.
- Trial name
- NCT00432003
- Where
- 45 sites in United States, Australia and 3 more
- Volunteers
- 297 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nitrous Oxide Abuse
Biological Diagnosis and Monitoring of Chronic Nitrous Oxide Abuse
There is a toxicity linked to the chronic use of nitrous oxide, leading to neurological disorders such as combined sclerosis of the spinal cord.
- Trial name
- BALON (NCT05540561)
- Testing
- blood collection
- Where
- 8 sites in France
- Volunteers
- 356 people
- Sponsor
- University Hospital, Lille
Ischemic Stroke, Intracerebral Hemorrhage
Evaluating the Safety and Efficacy of Telemedicine Neurology Assessments on a Mobile Stroke Unit
The goal of this clinical trial is to compare a telemedicine neurologist staffing model to a traditional on-board model in patients being assessed for suspected acute stroke on a mobile stroke unit.
- Trial name
- MSU-TELEMED (NCT05991310)
- Testing
- Telemedicine Assessment by Remote Neurologist, In-Person Assessment by an Onboard Neurologist
- Where
- Australia
- Volunteers
- 270 people
- Sponsor
- Melbourne Health
Nervous System Diseases
Domain-Specific Large Language Model Assistance for Emergency Neurological Diagnosis and Treatment（DEMAND）
This study will evaluate whether Xuanwu-NeuroAid 2.0, a large language model for emergency neurology, can improve 30-day diagnostic quality in adults with acute neurological symptoms.
- Trial name
- NCT07626229
- Testing
- Xuanwu-NeuroAid 2.0
- Where
- 3 sites in China
- Volunteers
- 1,381 people
- Sponsor
- Capital Medical University
Parkinson Disease, Orthostatic Hypotension
Cardiovascular Effects of Exercise in Patients With Parkinson's Disease
Abnormalities in the regulation of cardiovascular system due to autonomic nervous system (ANS) dysfunction may lead to a sudden decline in blood pressure (BP) upon standing, sitting or performing activities/exercises in patients…
- Trial name
- NCT03343574
- Testing
- Abdominal Strengthening Exercise
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Faizan Ahmed
Hemorrhage, Intracranial, Outcome Measure
Clinical Characteristics and Outcome of Patients With Hemorrhagic Stroke Admitted in Neurology Department in a Tertiary Hospital
The main aim of this study is to know about the clinical profile of patients who are diagnosed as hemorrhagic stroke as well as the factors that affect good and bad outcomes of those patients after 3 months.
- Trial name
- NCT06824311
- Where
- Nepal
- Volunteers
- 197 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Encephalitis, LGI1 Antibody Associated Encephalitis
Core Cerebrospinal Fluid Biomarker Profile in Anti-Leucine Rich Glioma Inactivated 1 (Anti-LGI1) Encephalitis
Limbic encephalitis associated with anti leucine-rich glioma inactivated-1 LGI1 antibody (anti-LGI1) usually presents with seizures and progressive disturbance of memory and behavior.
- Trial name
- LGI1biom (NCT04001270)
- Volunteers
- 24 people
- Sponsor
- Hospices Civils de Lyon
Stroke, Guillain-Barre Syndrome
Artificial Intelligence-powered Virtual Assistant for Emergency Triage in Neurology
This study examines the use of an AI-powered virtual assistant for quickly identifying and handling neurological emergencies, particularly in places with limited medical resources.
- Conditions
- Stroke, Guillain-Barre Syndrome, Facial Palsy, Migraine
- Trial name
- AIDEN (NCT06334796)
- Testing
- Virtual Assistant
- Where
- Argentina
- Volunteers
- 10 people
- Sponsor
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
Anticoagulant-induced Bleeding, Intracranial Hemorrhages
Anticoagulant-associated Intracranial Hemorrhage
Oral anticoagulant therapy, including factors Xa and 2a inhibitors has become more popular in recent years due to its efficacy and convenience in preventing thrombotic events and reducing the risk for stroke in patients with rosk…
- Trial name
- AAIHINNN (NCT06168838)
- Testing
- Anticoagulant
- Where
- Mexico
- Volunteers
- 1,200 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Neurologic Disorder
The Efficacy of Fycompa (Perampanel) in Children With Epilepsy
Fycompa (Perampanel), a new anti-epileptic drug that uses a new mechanism-AMPA receptor antagonist. Its initial indication is for local or generalized epilepsy in children and adults over 12 years old, but its effectiveness in…
- Trial name
- NCT04608799
- Testing
- Perampanel
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- National Taiwan University Hospital
Trigeminal Neuralgia
Comparison of Oxcarbazepine Versus Carbamazepine in the Management of Trigeminal Neuralgia
Trigeminal neuralgia is a debilitating neurological condition, affecting quality of life in most affected patients. Carbamazepine has traditionally been used for the management of this condition, but it has a moderate…
- Trial name
- NCT06849219
- Testing
- Oxcarbazepine, Carbamazepine
- Where
- Pakistan
- Volunteers
- 122 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Neurology, Aromatic Amino Acid Decarboxylase Deficiency
Newborn Screening and Early Diagnosis of AADC Deficiency in the Ligurian Population
Aromatic L-amino acid decarboxylase deficiency (AADC-D) is a rare genetic disorder that affects the production of neurotransmitters in the brain and can cause severe neurological and developmental problems.
- Conditions
- Neurology, Aromatic Amino Acid Decarboxylase Deficiency, Pediatric Neurological Disorder
- Trial name
- NBS3OMD22 (NCT07877714)
- Where
- 10 sites in Italy
- Volunteers
- 16,000 people
- Sponsor
- Istituto Giannina Gaslini
Stroke, Patient Education
Impact of a Nursing Educational Consultation on the Patient's Adherence to Their Post-stroke Care Plan.
This prospective, single-center, randomized study will evaluate the impact of implementing an educational nursing consultation at the end of hospitalisation for stroke patients returning home on overall adherence to…
- Trial name
- ICEIPAVC (NCT07524036)
- Testing
- nursing educational consultation
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bordeaux
Alzheimer Disease
Cognitive Neurology Unit Clinical Registry
A Prospective Comparative Study Of Monoclonal Antibodies For The Treatment Of Alzheimer's Disease
- Trial name
- NCT05925621
- Testing
- Lecanemab
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Beth Israel Deaconess Medical Center
Essential Tremor, Neurology
Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001)
Evaluate the safety and effectiveness of Echo-Focusing using Exablate Neuro as a tool for treating patients with treatment-refractory neurologic and psychiatric disorders.
- Trial name
- NCT05089786
- Testing
- Exablate Neuro Type 1.0 System with Echo Focusing
- Sponsor
- InSightec