Clinical trials: Neuromodulation and Sleep Disorders
Insomnia, Insomnia Chronic
Efficacy and Accuracy of an AI-Driven Sleep Earbud for Chronic Insomnia
This study evaluates a new smart sleep earbud designed to help adults suffering from chronic insomnia. The device uses artificial intelligence (AI) to track a user's real-time heart rate and movement through the ear canal…
- Conditions
- Insomnia, Insomnia Chronic, Insomnia Disorders, Sleep Wake Disorders
- Trial name
- NCT07744581
- Testing
- AI-driven Neuromodulation Music (NeuroRhythm)
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- The Chinese University of Hong Kong, Shenzhen
Schizophrenia
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights.
- Trial name
- NCT06386588
- Testing
- Closed loop auditory stimulation during sleep
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Frailty Syndrome, Dementia
The Impact of Transcutaneous Vagal Nerve Stimulation on Frailty Syndrome in Older Adults
This clinical study, conducted at the Techirghiol Balneary and Rehabilitation Sanatorium, aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in improving clinical and biological…
- Trial name
- NCT07416708
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, Physiotherapy
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Balnear and Rehabilitation Sanatorium Techirghiol
Parkinson Disease, Sleep Disorder
Neuromodulation of Sleep Architecture by STN-DBS in Parkinsonian Patients
Sleep disorder is one of the most burdensome non-motor symptoms in Parkinsonian patients. Typical manifestations include RBD, decreased sleep efficiency, decreased slow wave sleep, daytime sleepiness, increased sleep latency and…
- Trial name
- NCT04976569
- Testing
- STN-DBS stimulation pattern change
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Tsinghua University
Fibromyalgia
UHCDS a-tDCS Combined With Therapeutic Exercise in Fibromyalgia Patients
The purpose of this study is to assess the effects on fatigue and sleep of Unihemispheric Concurrent Dual-Site anodal Transcranial Direct Current Stimulation combined with therapeutic exercise in Fibromyalgia patients.
- Trial name
- NCT05726149
- Testing
- Real UHCDS a-tDCS, Therapeutic exercise
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Castilla-La Mancha
Sleep, Sleep Disturbance
Sounds Locked to ElectroEncephalogram Phase For the Acceleration of Sleep Onset Time
This study seeks to test whether auditory stimulation delivered at specific phases of the alpha oscillation (as measured by electroencephalogram) can accelerate sleep onset.
- Trial name
- SLEEPFAST (NCT05743114)
- Testing
- Elemind Neuromodulation (ENMod)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Elemind Technologies, Inc.
Mild Cognitive Impairment (MCI), Insomnia
Treating Insomnia in Mild Cognitive Impairment
The goal of this study is to test a new way to improve sleep quality in persons living with mild cognitive impairment. The treatment combines a safe and gentle way to stimulate the brain, called transcranial magnetic stimulation…
- Trial name
- NCT06687161
- Testing
- Transcranial Magnetic Stimulation (TMS) therapy, Cognitive behavioral therapy for insomnia (CBT-I)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sleep Disturbance, Stress, Psychological
Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement
This study evaluates a wearable system (NEUSleeP) that combines overnight EEG recording with transcranial focused ultrasound (tFUS) targeted to deep brain structures involved in REM sleep regulation (e.g., subthalamic nucleus).
- Conditions
- Sleep Disturbance, Stress, Psychological, REM Sleep Measurement
- Trial name
- NEUSleeP (NCT07190287)
- Testing
- NEUSleeP system (FUS-EEG wearable device), BrainSonix Pulsar 1002
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Long-COVID, Post-acute COVID-19 Syndrome
Effectiveness of Non-invasive Neuromodulation in Patients With Long-COVID
Sleep quality and duration are critical to cognitive, emotional and physical well-being, and poor sleep quality has been associated with an increased risk of cognitive, psychological and cardiometabolic disorders.
- Trial name
- NCT06456502
- Testing
- Non-invasive neuromodulation
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Universidad Rey Juan Carlos
Neuromodulation and Sleep Disorders
Interventional Neuromodulation in Fibromyalgia
This study was conducted on 40 eligible fibromyalgia patients with sleep disorders. They were randomized to have 20 sessions of active or sham rTMS (1 Hz, 120% of resting motor threshold with total 1200 pules /session) over the…
- Trial name
- NCT06373445
- Testing
- repetitive transcranial magnetic stimulation active stimulation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Multiple Sclerosis
Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis
The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS).
- Trial name
- CerebellertDCS (NCT07555379)
- Testing
- Bilateral Cerebellar Transcranial Direct Current Stimulation (ctDCS)
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- University of Sharjah
Obstructive Sleep Apnea
Assessment of OSA in Latin American and Response to Neuromod Therapy
The purpose of this study is to characterize the upper airway of Latin American subjects who have been diagnosed with moderate/severe obstructive sleep apnea (OSA) and assess response to a neuromodulation therapy to treat OSA.
- Trial name
- Trans-Q DISE (NCT06762873)
- Testing
- Drug Induced Sleep Endoscopy with PNS
- Where
- Paraguay
- Volunteers
- 50 people
- Sponsor
- Lunair Medical
Major Depressive Disorder (MDD), SCHIZOPHRENIA 1 (Disorder)
Transcranial Direct Current Stimulation (tDCS) in Different Psychiatric Disorders
The goal of this clinical trial is to evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in reducing core symptoms of different psychiatric disorders using validated clinical scales.
- Conditions
- Major Depressive Disorder (MDD), SCHIZOPHRENIA 1 (Disorder), Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
- Trial name
- Transcranial (NCT07452835)
- Testing
- tDCS Parameters
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Menoufia University
Major Depressive Episode, Major Depressive Disorder
Depression-Reduction by Accelerated Personalized NeuroModulation and Its Effects on Sleep
Advances in repetitive transcranial magnetic stimulation (rTMS) protocols with intermittent theta-burst stimulation (iTBS) have significantly decreased the duration for one single session and thereby enabled accelerated treatment…
- Conditions
- Major Depressive Episode, Major Depressive Disorder, Borderline Personality Disorder
- Trial name
- DREAMS (NCT04832750)
- Where
- Germany
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Oldenburg
Fibromyalgia, Chronic Fatigue Syndrome (CFS)
Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia
Fibromyalgia (FMS) is a chronic, multifactorial syndrome characterized by widespread pain, fatigue, and cognitive disturbances. This interventional study evaluates the impact of structured physical training using…
- Trial name
- NCT07242573
- Testing
- Physical Training Program, NESA X-Signal, Conventional Physiotherapy
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
Neurodevelopmental Disorders
Non-Invasive Neuromodulation in Children With Neurodevelopmental Disorders
Children with neurodevelopmental disorders have a delay in acquiring the skills that are assumed considering the phases of typical psychomotor development.
- Trial name
- NCT05265702
- Testing
- Non-invasive Neuromodulation
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- University of Las Palmas de Gran Canaria
Pain, Peripheral Neuropathy
Effects of Neurofeedback on Neural Function, Neuromodulation, and Chemotherapy-Induced Neuropathic Pain
The goal of this study is to learn if using a non-invasive therapy called "neurofeedback training" can help teach patients ways to modify their own brain waves to decrease the perception of pain and improve quality of life.
- Trial name
- NCT01278225
- Testing
- EEG biofeedback (BF) Group, Wait-List Control (WLC) Group, Follow UP Questionnaires
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Bruxism, Sleep
Surface Electromyography in the Detection and Assessment of Bruxism
Introduction: Sleep bruxism is defined as the repetitive activity of the masticatory muscles, characterized by clenching or grinding of the teeth.
- Trial name
- EMGBruxism (NCT07070947)
- Testing
- sEMG
- Where
- Spain
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Escoles Universitaries Gimbernat
Caregivers
Cereset Research for Caregivers
Caregivers experience high levels of prolonged stress that can lead to chronic problems with health, including increased risk of cardiovascular disease that is linked to autonomic dysregulation.
- Trial name
- NCT05209438
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Subjective Tinnitus
A Multicenter Study of Noninvasive Neuromodulation Treatment for Subjective Tinnitus
The purpose of this study is to find out the scientific and effectiveness of non-invasive neuromodulation therapy for subjective tinnitus and further guide the clinical response to tinnitus problems.
- Trial name
- NCT06727175
- Testing
- non-invasive neuromodulation therapy, before any intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University