Clinical trials: Neuromuscular Block
OSA, Rocuronium
Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea
This study describe the effect of partial neuromuscular blockade of rocuronium on the acute hypoxic ventilatory response in patients with OSA before and after 3 month of CPAP treatment.
- Conditions
- OSA, Rocuronium, Neuromuscular Blockade, Hypoxic Ventilatory Response
- Trial name
- NCT01672606
- Testing
- Rocuronium
- Where
- Sweden
- Volunteers
- 11 people
- Sponsor
- Malin Jonsson Fagerlund
Postoperative Residual Curarisation, Postoperative Hypoxemia
Postoperative Residual Curarisation at Arrival in the Post-anesthesia Care Unit
Several studies have documented that neuromuscular block often persists in the postanesthesia care unit (PACU). Residual paralysis is associated with postoperative complications such as hypoxia, weakness, and respiratory failure.
- Conditions
- Postoperative Residual Curarisation, Postoperative Hypoxemia, Postoperative Airway Obstruction
- Trial name
- NCT01362647
- Testing
- neuromuscular transmission monitoring, Pulse oximetry measurement
- Where
- Belgium
- Volunteers
- 625 people
- Sponsor
- Onze Lieve Vrouw Hospital
Chronic Venous Disease, Venous Insufficiency
Venous Insufficiency and Neuromuscular Stimulation
The investigators will be evaluating the immediate and longer term effect of treatment with a medical device on the symptoms of chronic venous disease.
- Conditions
- Chronic Venous Disease, Venous Insufficiency, Deep Venous Obstruction
- Trial name
- VeINS (NCT02137499)
- Testing
- geko device
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bulbar Palsy
Stellate Ganglion Block in Bulbar Palsy
This is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine in 3 hospitals in China.
- Trial name
- NCT06319534
- Testing
- Comprehensive rehabilitation, Stellate ganglion block, Lidocaine Hydrochloride
- Where
- 6 sites in China
- Volunteers
- 124 people
- Sponsor
- Zeng Xi
Myotoxicity
CPK Levels After LC and Association With Analgesic Modalities
Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia.
- Trial name
- NCT06508177
- Testing
- İnterfascial plane block, Standart analgesia plan
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Samsun University
MELAS Syndrome, Mitochondrial Respiratory Chain Deficiencies
Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers
The purpose of this First In Human study is to investigate the safety and tolerability of KL1333 after a single oral dose and to investigate the pharmacokinetic characteristics of KL1333 after a single oral dose.
- Trial name
- NCT03056209
- Testing
- KL1333 25 mg, KL1333 50 mg, KL1333 100 mg
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Thyroid, Neuromuscular Blockade
Anaesthesia With or Without Rocuronium in Intubation and Intraoperative Nerve-monitoring During Thyroid Surgery.
In this randomized controlled trial the investigators want to assess if, compared to controls, the administration of one single low-dose of rocuronium would increase the occurrence of absent or weak (i.e.
- Conditions
- Thyroid, Neuromuscular Blockade, Anesthesia Complication, Anesthesia Intubation Complication
- Trial name
- NCT03910504
- Testing
- Rocuronium 0.3 mg*kg, No Rocuronium
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico Longhini
Residual Neuromuscular Blockade
Reversal of Neuromuscular Blockade in Thoracic Surgical Patients
The majority of patients undergoing surgery receive neuromuscular blocking agents (NMBAs) in the operating room. Reversal of neuromuscular blockade at the conclusion of a general anesthetic is accomplished with cholinesterase…
- Trial name
- NCT01837498
- Testing
- Neostigmine, Sugammadex
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Endeavor Health
Intraocular Pressure Changes During Tracheal Extubation
Intraocular Pressure Changes Associated With Tracheal Extubation: Comparison of Sugammadex With Conventional Reversal of Neuromuscular Blockade
The aim of this study, comparison of effects of sugammadex versus neostigmine/atropine combination on hemodynamic parameters and intraocular pressure during tracheal extubation.
- Trial name
- NCT02215382
- Testing
- sugammadex, neostigmine+atropine
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Ordu University
Gastrointestinal Cancer, Sarcopenia
Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery
This prospective observational study aims to evaluate the effects of sarcopenia on intraoperative neuromuscular block (NMB) in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Cancer, Sarcopenia, Neuromuscular Blockade
- Trial name
- NCT07003061
- Testing
- Standard Anesthesia Management
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Neuromuscular Blockade
Comparing Reversal With Neostigmine and Sugammadex in Paediatric
A reversal agent is commonly given to improve neuromuscular function after intra-operative administration of non-depolarizing neuromuscular blocking agents.
- Trial name
- JS (NCT03137290)
- Testing
- Neostigmine, Sugammadex Sodium
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Respiratory Muscle Paralysis
Respiratory Muscle Strength and Function in Neuromuscular Disorders and Chronic Obstructive Pulmonary Disease
Using an extensive set of both volitional and non-volitional tests of respiratory muscle function and strength it is the aim of this study to identify disease-specific patterns of respiratory muscle impairment in different NMD…
- Trial name
- NCT03032562
- Testing
- Multimodal measurement of respiratory muscle function and strength
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Universität Münster
Neuromuscular Blockade, Pulmonary Complication
Incidence of Residual Neuromuscular Blockade in Intra-abdominal Surgery: A Prospective, Observational Study
The aim of this prospective, observational study is to determine the incidence of post-operative residual neuromuscular blockade (PRNB) in patients undergoing intra-abdominal procedures compared to patients undergoing other…
- Trial name
- NCT02984839
- Testing
- Stimpod NMS450® Nerve Stimulator, by Xavant™ Technology
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- OhioHealth
Neuromuscular Blockade
Interaction Between Magnesium and Neostigmine or Sugammadex for the Reversal of a Rocuronium-induced Neuromuscular Block
Magnesium sulphate is regularly used in perioperative medicine. During and after general anesthesia, it enhances the effect of muscle relaxants because it reduces the liberation of acetylcholine at the neuromuscular junction.
- Trial name
- MagNeoSug (NCT03497923)
- Testing
- Magnesium Sulfate
- Where
- 2 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- Christoph Czarnetzki
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis
The use of intravenous muscle relaxants during anaesthesia can significantly facilitate endotracheal intubation and reduce the chance of possible airway complications during intubation.
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
- Trial name
- NCT07080528
- Testing
- Sevofluorane, Propofol
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Cholecystitis, Inguinal Hernia, Direct
No Need for Neuromuscular Blockade in Daycase Laparoscopic Surgery
This study analyse the need for neuromuscular blockade in consecutive routine laparoscopic procedures without standard use of neuromuscular blockade in an ambulatory laparoscopic surgery setting and analyse specific reasons for…
- Conditions
- Cholecystitis, Inguinal Hernia, Direct, Umbilical Hernia
- Trial name
- NCT02782832
- Volunteers
- 1,245 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Anesthesia, General, Neuromuscular Blockade
Pharmacokinetic-pharmacodynamic Analysis of Sugammadex in Children
This study administers sugammadex sodium to pediatric patients under general anesthesia with rocuronium. Pharmacokinetic and pharmacodynamic analysis are performed based on plasma concentration of sugammadex sodium and monitoring…
- Trial name
- NCT03943888
- Testing
- Sugammadex Injection 2mg/kg, Sugammadex Injection 4mg/kg, Sugammadex Injection 8mg/kg
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Meralgia Paresthetica
Comparing Ways to Freeze the Nerve That Provides Thigh Sensation
Background The sensation on the outside of portion of our thighs is provided by a nerve called the lateral femoral cutaneous nerve (LFCN).
- Trial name
- NCT02577510
- Testing
- Nerve Injection- Nerve Stimulator, Nerve Injection - Ultrasound
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Canadian Forces Health Services Centre Ottawa
Incidence of Postoperative Residual Curarization
Combined Use of Low-dose Sugammadex Plus Neostigmine Administered for Reversal of Rocuronium
Reversal of rocuronium-induced neuromuscular block by the combination of low-doses of neostigmine plus sugammadex decreases the cost of anesthetic medications, while maintaining efficacy of reversal in obese patients.
- Trial name
- NCT03328312
- Testing
- Sugammadex, neostigmine+atropine, neostigmine+atropine+sugammadex
- Volunteers
- 90 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Sugammadex
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- NCT05003024
- Testing
- TOF SCAN, ITF
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital